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  3. Principles and Practice of Fertility Preservation
  • Cited by 7
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    • Publisher:
      Cambridge University Press
      Publication date:
      February 2011
      February 2011
      ISBN:
      9780511921896
      DOI:
      https://doi.org/10.1017/CBO9780511921896
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      • Subjects:
      Oncology, Obstetrics and Gynecology, Reproductive Medicine, Medicine
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    Subjects:
    Oncology, Obstetrics and Gynecology, Reproductive Medicine, Medicine
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    Book description

    The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

    Reviews

    'One of the outstanding features of this book is the merging of oncology and reproduction so that people in both fields will benefit from reading it … appropriate for a wide audience.'

    Source: Doody's Notes

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    Contents

    Page 3 of 3

    Contents
    • Chapter 42 - Legal aspects of fertility preservation
      pp 488-496
    • View abstract

      Summary

      Early detection and aggressive chemotherapy/radiotherapy treatments have improved the long-term survival rates for many young women with various types of cancer. The structure of the human ovary is a crucial consideration in the potential success of cryopreservation. Four permeating cryoprotectants, glycerol (GLY), dimethyl sulfoxide (DMSO), ethylene glycol (EG), and propanediol (propylene glycol; PROH), have been used in human and animal ovarian tissue cryopreservation. In contrast to evaluation of outcomes from embryo or gamete cryopreservation, assessing the survival and viability of cryopreserved ovarian tissue poses specific challenges. There are only two morphometric studies of human ovarian tissue which assess cryopreservation, one of which is an evaluation of the most commonly used procedure using DMSO as a cryoprotectant and controlled rate cooling on tissue from six patients. Clinical evidence has established that fertilization and embryo development can occur in oocytes recovered from cryopreserved ovarian tissue transplanted at a heterotopic site.
    • Chapter 43 - Christian ethics in fertility preservation
      pp 497-506
    • View abstract

      Summary

      Advances in the diagnosis and treatment of childhood, adolescent and adult cancer have increased the life expectancy of premenopausal women with the disease. Oncological indications for ovarian tissue cryopreservation are summarized. Patients undergoing oophorectomy for prophylaxis may potentially benefit from ovarian cryopreservation. There have been numerous reported cases of autotransplantation of cryopreserved ovarian tissue, either to an orthotopic or heterotopic site. Approximately one third of young women exposed to chemotherapy develop ovarian failure. It is our ethical responsibility to propose cryopreservation of ovarian tissue to all adolescents and young women under institutional review board (IRB) protocols having to undergo chemotherapy with alkylating agents. Research programs need to determine whether active angiogenesis can be induced to accelerate the process of neovascularization in grafted tissue, if isolated human follicles can be grafted or, indeed, if microvascular re-anatomosis of an entire cryopreserved ovary is a valuable option.

    Page 3 of 3

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