Sanctions regimes can and have had both direct and indirect negative impacts on humanitarian action. These include restrictions on goods necessary for a humanitarian response, and de-risking by private sector actors, which restricts or prevents humanitarian organizations from accessing the services these actors provide, such as banking or transport. These challenges have been documented in humanitarian crises across the world, from Syria to Somalia, Afghanistan, and Sudan, hindering the ability of those in need to access and receive assistance and protection. There are several ways in which we can ensure sanctions regimes do not hinder aid. Chief among them is the inclusion in sanctions regimes of humanitarian exemptions, which explicitly exclude humanitarian action from their scope of application. Although progress on that front in recent years has helped, challenges remain. This chapter highlights the need for continued efforts to ensure that humanitarian action is safeguarded. These include the development of guidance on the scope of sanctions and on humanitarian exemptions, continued awareness-raising of the issue, stronger dialogue and engagement between governments, the private sector, and humanitarian organizations, and better risk sharing. Overall, there is a need to continue to put the focus on the dramatic needs of millions of people who depend on humanitarian organizations being able to do their work without hindrance and in accordance with international humanitarian law (IHL).