This chapter addresses some of the many ways that unilateral coercive measures run counter to international human rights law. Such measures may directly compromise the human rights to health, education, economic and social rights, and the right to development as well as sustainable development goals. The chapter addresses the expanding practice of the use of unilateral sanctions, provides an assessment of the possibility of imposing unilateral sanctions as countermeasures or retorsions, and provides an overview of the humanitarian impact of different types of sanctions on different categories of human rights. It looks at the recent developments in sanctioning practice. In particular, as targeted sanctions are usually presented as a good alternative to the comprehensive ones, minimizing humanitarian impact of unilateral measures, the chapter addresses the grounds for targeted unilateral sanctions, assesses their impact on the human rights of directly designated individuals, as well as other people and targeted populations in general. It concludes that listings of individuals regularly run counter to the right to due process. Additionally, most recently unilateral sanctions have compromised internet access, which in turn undermines access to many essential services.