This chapter discusses the crucial role of sampling in quantitative research. Selecting an appropriate sample is essential, as it directly impacts the validity and reliability of the study’s findings. The chapter explores various sampling procedures and the key factors that must be considered when determining both the sampling method and the appropriate sample size. It begins by clarifying the concepts of sampling frames and populations, discussing their significance in selecting a representative sample from a larger group. The chapter then examines various sampling strategies, including probability and non-probability methods and discussing the advantages and disadvantages of each. Understanding these approaches will enable you to make informed decisions tailored to your specific research questions. Finally, the chapter guides you through calculating the required sample sizes for your studies and examining the factors that influence sample size determination. By the end of this chapter, you will not only see the importance of effective sampling but also have the knowledge to apply these concepts confidently in your own quantitative research studies.