This article furthers our understanding of commercial fishing on the lower Tiber during the Republic and Principate, arguing for a robust industry in the center of Rome. Literary references to the lupus fish and a fishing site “between the bridges” direct attention to the area of the river around the Cloaca Maxima and Tiber Island. Situating intensive fishing there requires reconciliation with other commercial uses of the river, a common-pool resource shared by users with divergent and competing needs. Epigraphic evidence offers insight into professional associations and attendant relationships that were leveraged in favor of the interests of both fishermen and barge operators. I contend that two separate navigation zones existed, to the north and to the south of Tiber Island, and that transport barges venturing inland from Ostia did not navigate beyond Rome’s southern wharves. This system enabled fishing and barge traffic to coexist, protecting numerous interests and allowing for the unimpeded transportation of goods.