Hostname: page-component-68c7f8b79f-mrqgn Total loading time: 0 Render date: 2026-01-15T04:14:10.002Z Has data issue: false hasContentIssue false
  • English
  • Français

Epidemiologic validation of the National Healthcare Safety Network’s updated Clostridioides difficile test method definition

Published online by Cambridge University Press:  14 July 2025

Nicholas A. Turner Open the ORCID record for Nicholas A. Turner [Opens in a new window] ,
Barry Shelton ,
Becky A. Smith ,
Linda Crane ,
Polly Padgette ,
Linda Roach ,
Brittain Wood ,
Diana Alame  and
Deverick J. Anderson Open the ORCID record for Deverick J. Anderson [Opens in a new window]
Nicholas A. Turner*
Affiliation:
Duke University Medical Center, Division of Infectious Diseases, Durham, NC, USA Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, NC, USA Duke Infection Control Outreach Network, Durham, NC, USA
Barry Shelton
Affiliation:
Duke Infection Control Outreach Network, Durham, NC, USA
Becky A. Smith
Affiliation:
Duke University Medical Center, Division of Infectious Diseases, Durham, NC, USA Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, NC, USA Duke Infection Control Outreach Network, Durham, NC, USA
Linda Crane
Affiliation:
Duke Infection Control Outreach Network, Durham, NC, USA
Polly Padgette
Affiliation:
Duke Infection Control Outreach Network, Durham, NC, USA
Linda Roach
Affiliation:
Duke Infection Control Outreach Network, Durham, NC, USA
Brittain Wood
Affiliation:
Duke Infection Control Outreach Network, Durham, NC, USA
Diana Alame
Affiliation:
Duke Clinical Microbiology Laboratory, Durham, NC, USA
Deverick J. Anderson
Affiliation:
Duke University Medical Center, Division of Infectious Diseases, Durham, NC, USA Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, NC, USA
*
Corresponding author: Nicholas A. Turner; Email: nick.turner@duke.edu.
Get access Rights & Permissions [Opens in a new window]

Abstract

This longitudinal survey examined the effect of the National Healthcare Safety Network’s (NHSN) recently updated Clostridioides difficile test method definition on reporting of hospital-onset C. difficile. Among six hospitals with ≥ 5 years of data available, the updated NHSN definition was associated with improved concordance between predicted versus reported cases.

Information

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 46 , Issue 8 , August 2025 , pp. 845 - 848
Check for updates
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Echenique, IA, Penugonda, S, Stosor, V, Ison, MG, Angarone, MP. Diagnostic yields in solid organ transplant recipients admitted with diarrhea. Clin Infect Dis. 2015;60:729–737.CrossRefGoogle ScholarPubMed
Mawer, D, Byrne, F, Drake, S, et al. Cross-sectional study of the prevalence, causes and management of hospital-onset diarrhoea. J Hosp Infect. 2019;103:200–209.CrossRefGoogle ScholarPubMed
Blanco-Míguez, A, Beghini, F, Cumbo, F, et al. Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4. Nature Biotechnology. 2023;41:1633–1644.CrossRefGoogle ScholarPubMed
Turner, NA, Krishnan, J, Nelson, A, et al. Assessing the impact of 2-step Clostridioides difficile testing at the Healthcare facility level. Clin Infect Dis. 2023;77:1043–1049.CrossRefGoogle ScholarPubMed
CDC/NHSN surveillance definitions for specific types of infections. National Healthcare Safety Network. https://www.cdc.gov/nhsn/pdfs/pscmanual/pcsmanual_current.pdf. Published 2022. Accessed June 28, 2022.Google Scholar
Turner, NA, Grambow, SC, Woods, CW, et al. Epidemiologic trends in Clostridioides difficile infections in a Regional Community Hospital Network. JAMA Netw Open. 2019;2:e1914149.CrossRefGoogle Scholar
Turner, NA, Krishnan, J, Nelson, A, et al. CDC’s hospital-onset Clostridioides difficile prevention framework in a Regional Hospital Network. JAMA Netw Open. 2024;7:e243846.CrossRefGoogle Scholar
Supplementary material: File

Turner et al. supplementary material

Turner et al. supplementary material
Download Turner et al. supplementary material(File)
File 375.6 KB