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Surgical undercutting prevents receptor redistribution in developing kitten visual cortex

Published online by Cambridge University Press:  02 June 2009

C. Shaw ,
G. Prusky  and
M. Cynader
C. Shaw
Affiliation:
Department of Ophthalmology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia
G. Prusky
Affiliation:
Departments of Psychology, Physiology, and Biophysics, Dalhousie University, Halifax, Nova Scotia
M. Cynader
Affiliation:
Department of Ophthalmology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia
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Abstract

Recent studies have shown that several receptor populations in cat visual cortex undergo alterations in their laminar distributions during postnatal development (Shaw et al., 1984a, b; 1986b). These redistributions occur during the first few months of postnatal life, coincident with the physiologically defined critical period for cortical plasticity. In the present communication, we demonstrate that receptor redistributions can be prevented from occurring, or progressing once started, by surgically isolating the visual cortex at appropriate postnatal ages. These data suggest that the maturation of the chemical circuitry of the visual cortex is dependent on factors of extrinsic origin.

Keywords

ReceptorAcetylcholineCholecystokininAdenosineGABALaminar distributionCat visual cortexPostnatal developmentCritical period

Information

Type
Research Article
Information
Visual Neuroscience , Volume 1 , Issue 2 , March 1988 , pp. 205 - 210
Copyright
Copyright © Cambridge University Press 1988

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References

Bear, M.F., Carnes, K.M. & Ebner, F.F. (1985). An investigation of cholinergic circuitry in cat striate cortex using acetylcholinesterase histochemistry. Journal of Comparative Neurology 234, 411–430.CrossRefGoogle ScholarPubMed
Bear, M.F. & Singer, W. (1986). Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature 320, 172–176.CrossRefGoogle ScholarPubMed
Cynader, M. & Shaw, C. (1986). Mechanisms underlying developmental alterations of cortical ocular dominance. In Adaptive Processes in Visual and Oculomotor Systems, Vol. 57, ed. Keller, E.L. & Zee, D.S., pp. 53–62. Oxford: Pergamon Press.Google Scholar
Cynader, M., Timney, B.N. & Mitchell, D.E. (1980). Period of susceptibility of kitten visual cortex to the effects of monocular deprivation extends beyond six months of age. Brain Research 191, 545–550.CrossRefGoogle Scholar
Hubel, D.H. & Wiesel, T.N. (1970). The period of susceptibility to the physiological effects of unilateral eye closure in kittens. Journal of Physiology (Lond) 206, 419–436.CrossRefGoogle Scholar
Jacobowitz, D.M. & Creed, G.J. (1983). Cholinergic projection sites of the nucleus of tractus diagonalis. Brain Research Bulletin 10, 365–371.CrossRefGoogle ScholarPubMed
Koelle, G.B. (1955). The histochemical identification of acetylcholinesterase in cholinergic, adrenergic, and sensory neurons. Journal of Pharmacology and Experimental Therapeutics 114, 167–184.Google ScholarPubMed
Lewis, P.R. & Shute, C.C.D. (1967). The cholinergic limbic system. Projections to hippocampal formation, medial cortex, nuclei of the ascending cholinergic reticular system, and the subfornical organ and supra-optic crest. Brain 90, 521–540.CrossRefGoogle ScholarPubMed
Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Luskin, M.B. & Shatz, C. (1984). Spatiotemporal relations between the cells of layers 4 and 6 and their geniculocortical afferent input during development. Society for Neuroscience Abstracts 10, 1079.Google Scholar
Needer, M.C., Shaw, C. & Cynader, M. (1984). Characteristics and distribution of muscimol binding sites in cat visual cortex. Brain Research 308, 347–352.CrossRefGoogle Scholar
Olson, C.R. & Freeman, R.D. (1980). Profile of the sensitive period for monocular deprivation in kittens. Experimental Brain Research 39, 17–21.CrossRefGoogle ScholarPubMed
Prusky, G., Shaw, C. & Cynader, M. (1987). Nicotine receptors are located on lateral geniculate nucleus terminals in cat visual cortex. Brain Research 412, 131–138.CrossRefGoogle ScholarPubMed
Rutledge, L.T. (1978). The effects of denervation and stimulation upon synaptic ultrastructure. Journal of Comparative Neurology 178, 117–128.CrossRefGoogle ScholarPubMed
Shaw, C. & Cynader, M. (1985). Alterations in the laminar distribution of pentagastrin binding sites in cat visual cortex during postnatal development. Developmental Brain Research 20, 132–136.CrossRefGoogle Scholar
Shaw, C., Needler, M.C., Wilkinson, M., Aoki, C. & Cynader, M. (1984a). Alterations in receptor number, affinity, and laminar distribution in cat visual cortex during the critical period. Progress in Neuropsychopharmacology and Biological Psychiatry 8, 627–634.CrossRefGoogle ScholarPubMed
Shaw, C., Hall, S.E. & Cynader, M. (1986a). Characterization, distribution, and ontogenesis of adenosine binding sites in cat visual cortex. Journal of Neuroscience 6, 3318–3328.CrossRefGoogle ScholarPubMed
Shaw, C., Needler, M.C. & Cynader, M. (1984b). Ontogenesis of muscarinic acetylchoine binding sites in cat visual cortex: reversal of specific laminar distribution during the critical period. Developmental Brain Research 14, 295–299.CrossRefGoogle Scholar
Shaw, C., Needler, M.C. & Cynader, M. (1984c). Ontogenesis of muscimol binding sites in cat visual cortex. Brain Research Bulletin 13, 331–334.CrossRefGoogle ScholarPubMed
Shaw, C., Wilkinson, M., Cynader, M., Needler, M.C., Aoki, C. & Hall, S.E. (1986b). The laminar distribution and postnatal development of neurotransmitter and neuromodulator receptors in cat visual cortex. Brain Research Bulletin 16, 661–671.CrossRefGoogle ScholarPubMed
Shute, C.C.D. & Lewis, P.R. (1967). The ascending cholinergic reticular system: neocortical olfactory, and subcortical projections. Brain 90, 497–520.CrossRefGoogle ScholarPubMed
Wong-Riley, M. (1979). Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. Brain Research 171, 11–28.CrossRefGoogle ScholarPubMed