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The influences of metabotropic receptor activation on cellular signaling and synaptic function in amacrine cells

Published online by Cambridge University Press:  25 August 2011

EVANNA GLEASON
EVANNA GLEASON*
Affiliation:
Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana
*
*Address correspondence and reprint requests to: Evanna Gleason, Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803. E-mail: egleaso@lsu.edu
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Abstract

Amacrine cells receive glutamatergic input from bipolar cells and GABAergic, glycinergic, cholinergic, and dopaminergic input from other amacrine cells. Glutamate, GABA, glycine, and acetylcholine (ACh) interact with ionotropic receptors and it is these interactions that form much of the functional circuitry in the inner retina. However, glutamate, GABA, ACh, and dopamine also activate metabotropic receptors linked to second messenger pathways that have the potential to modify the function of individual cells as well as retinal circuitry. Here, the physiological effects of activating dopamine receptors, metabotropic glutamate receptors, GABAB receptors, and muscarinic ACh receptors on amacrine cells will be discussed. The retina also expresses metabotropic receptors and the biochemical machinery associated with the synthesis and degradation of endocannabinoids and sphingosine-1-phosphate (S1P). The effects of activating cannabinoid receptors and S1P receptors on amacrine cell function will also be addressed.

Keywords

G protein-coupled receptorsSphingosine-1-phosphateModulationLipid signaling

Information

Type
Review Article
Information
Visual Neuroscience , Volume 29 , Issue 1 , January 2012 , pp. 31 - 39
Copyright
Copyright © Cambridge University Press 2011

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