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Depression and risk of gastrointestinal disorders: a comprehensive two-sample Mendelian randomization study of European ancestry

Published online by Cambridge University Press:  15 May 2023

Dongze Chen Open the ORCID record for Dongze Chen [Opens in a new window] ,
Yali Zhang ,
Tao Huang  and
Jinzhu Jia
Dongze Chen*
Affiliation:
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China
Yali Zhang
Affiliation:
Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100083, China
Tao Huang
Affiliation:
Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191 China
Jinzhu Jia*
Affiliation:
Department of Biostatistics, School of Public Health, Peking University, Beijing, China Center for Statistical Science, Peking University, Beijing, China
*
Corresponding author: Jinzhu Jia; Email: jzjia@math.pku.edu.cn; Dongze Chen; Email: dz_chen@pku.edu.cn
Corresponding author: Jinzhu Jia; Email: jzjia@math.pku.edu.cn; Dongze Chen; Email: dz_chen@pku.edu.cn
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Abstract

Background

Major depressive disorder (MDD) is clinically documented to co-occur with multiple gastrointestinal disorders (GID), but the potential causal relationship between them remains unclear. We aimed to evaluate the potential causal relationship of MDD with 4 GID [gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), peptic ulcer disease (PUD), and non-alcoholic fatty liver disease (NAFLD)] using a two-sample Mendelian randomization (MR) design.

Methods

We obtained genome-wide association data for MDD from a meta-analysis (N = 480 359), and for GID from the UK Biobank (N ranges: 332 601–486 601) and FinnGen (N ranges: 187 028–218 792) among individuals of European ancestry. Our primary method was inverse-variance weighted (IVW) MR, with a series of sensitivity analyses to test the hypothesis of MR. Individual study estimates were pooled using fixed-effect meta-analysis.

Results

Meta-analyses IVW MR found evidence that genetically predicted MDD may increase the risk of GERD, IBS, PUD and NAFLD. Additionally, reverse MR found evidence of genetically predicted GERD or IBS may increase the risk of MDD.

Conclusions

Genetically predicted MDD may increase the risk of GERD, IBS, PUD and NAFLD. Genetically predicted GERD or IBS may increase the risk of MDD. The findings may help elucidate the mechanisms underlying the co-morbidity of MDD and GID. Focusing on GID symptoms in patients with MDD and emotional problems in patients with GID is important for the clinical management.

Keywords

Gastroesophageal reflux diseaseirritable bowel syndromemajor depressive disorderMendelian randomizationnon-alcoholic fatty liver diseasepeptic ulcer disease

Information

Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 15 , November 2023 , pp. 7309 - 7321
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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References

Collaborators, G. D. a. I. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet (London, England), 396(10258), 1204–1222. doi: 10.1016/s0140-6736(20)30925-9CrossRefGoogle Scholar
Ali, T., Choe, J., Awab, A., Wagener, T. L., & Orr, W. C. (2013). Sleep, immunity and inflammation in gastrointestinal disorders. World Journal of Gastroenterology, 19(48), 9231–9239. doi: 10.3748/wjg.v19.i48.9231CrossRefGoogle ScholarPubMed
Al-Sadi, R., Guo, S., Ye, D., Rawat, M., & Ma, T. Y. (2016). TNF-α modulation of intestinal tight junction permeability is mediated by NIK/IKK-α axis activation of the canonical NF-κB pathway. The American Journal of Pathology, 186(5), 1151–1165. doi: 10.1016/j.ajpath.2015.12.016CrossRefGoogle ScholarPubMed
Altena, E., Micoulaud-Franchi, J. A., Geoffroy, P. A., Sanz-Arigita, E., Bioulac, S., & Philip, P. (2016). The bidirectional relation between emotional reactivity and sleep: From disruption to recovery. Behavioral Neuroscience, 130(3), 336–350. doi: 10.1037/bne0000128CrossRefGoogle ScholarPubMed
Altomare, A., Guarino, M. P., Cocca, S., Emerenziani, S., & Cicala, M. (2013). Gastroesophageal reflux disease: Update on inflammation and symptom perception. World Journal of Gastroenterology, 19(39), 6523–6528. doi: 10.3748/wjg.v19.i39.6523CrossRefGoogle ScholarPubMed
An, J., Gharahkhani, P., Law, M. H., Ong, J. S., Han, X., Olsen, C. M., … MacGregor, S. (2019). Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. Nature Communications, 10(1), 4219. doi: 10.1038/s41467-019-11968-2CrossRefGoogle ScholarPubMed
Aziz, M. N. M., Kumar, J., Muhammad Nawawi, K. N., Raja Ali, R. A., & Mokhtar, N. M. (2021). Irritable bowel syndrome, depression, and neurodegeneration: A bidirectional communication from gut to brain. Nutrients, 13(9), 3061. doi: 10.3390/nu13093061CrossRefGoogle ScholarPubMed
Ballou, S., McMahon, C., Lee, H. N., Katon, J., Shin, A., Rangan, V., … Iturrino, J. (2019). Effects of irritable bowel syndrome on daily activities vary among subtypes based on results from the IBS in America Survey. Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 17(12), 2471–2478, e2473. doi: 10.1016/j.cgh.2019.08.016CrossRefGoogle ScholarPubMed
Berk, M., Williams, L. J., Jacka, F. N., O'Neil, A., Pasco, J. A., Moylan, S., … Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11, 200. doi: 10.1186/1741-7015-11-200CrossRefGoogle ScholarPubMed
Bhanji, R. A., Narayanan, P., Allen, A. M., Malhi, H., & Watt, K. D. (2017). Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.), 66(6), 2055–2065. doi: 10.1002/hep.29420CrossRefGoogle ScholarPubMed
Bica, T., Castelló, R., Toussaint, L. L., & Montesó-Curto, P. (2017). Depression as a risk factor of organic diseases:An international integrative review. Journal of Nursing Scholarship: an Official Publication of Sigma Theta Tau International Honor Society of Nursing, 49(4), 389–399. doi: 10.1111/jnu.12303CrossRefGoogle ScholarPubMed
Bowden, J., Del Greco, M. F., Minelli, C., Zhao, Q., Lawlor, D. A., Sheehan, N. A., … Davey Smith, G. (2019). Improving the accuracy of two-sample summary-data Mendelian randomization: Moving beyond the NOME assumption. International Journal of Epidemiology, 48(3), 728–742. doi: 10.1093/ije/dyy258CrossRefGoogle ScholarPubMed
Brahm, N. C., & Kelly-Rehm, M. C. (2011). Antidepressant-mediated gastroesophageal reflux disease. The Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists, 26(4), 274–278. doi: 10.4140/TCP.n.2011.274CrossRefGoogle ScholarPubMed
Burgess, S. (2014). Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome. International Journal of Epidemiology, 43(3), 922–929. doi: 10.1093/ije/dyu005CrossRefGoogle Scholar
Burgess, S., Butterworth, A., & Thompson, S. G. (2013). Mendelian randomization analysis with multiple genetic variants using summarized data. Genetic Epidemiology, 37(7), 658–665. doi: 10.1002/gepi.21758CrossRefGoogle ScholarPubMed
Burgess, S., Davies, N. M., & Thompson, S. G. (2016). Bias due to participant overlap in two-sample Mendelian randomization. Genetic Epidemiology, 40(7), 597–608. doi: 10.1002/gepi.21998CrossRefGoogle ScholarPubMed
Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2), 203–209.Google ScholarPubMed
Chan, K. L., Cathomas, F., & Russo, S. J. (2019). Central and peripheral inflammation link metabolic syndrome and major depressive disorder. Physiology (Bethesda, Md.), 34(2), 123–133. doi: 10.1152/physiol.00047.2018Google ScholarPubMed
Chen, Y. H., & Wang, H. (2020). The association between depression and gastroesophageal reflux based on phylogenetic analysis of miRNA biomarkers. Current Medicinal Chemistry, 27(38), 6536–6547. doi: 10.2174/0929867327666200425214906CrossRefGoogle ScholarPubMed
Choi, J. M., Yang, J. I., Kang, S. J., Han, Y. M., Lee, J., Lee, C., … Kim, Y. S. (2018). Association between anxiety and depression and gastroesophageal reflux disease: Results from a large cross-sectional study. Journal of Neurogastroenterology and Motility, 24(4), 593–602. doi: 10.5056/jnm18069CrossRefGoogle ScholarPubMed
Demeter, P., & Pap, A. (2004). The relationship between gastroesophageal reflux disease and obstructive sleep apnea. Journal of Gastroenterology, 39(9), 815–820. doi: 10.1007/s00535-004-1416-8CrossRefGoogle ScholarPubMed
Didelez, V., & Sheehan, N. (2007). Mendelian randomization as an instrumental variable approach to causal inference. Statistical Methods in Medical Research, 16(4), 309–330. doi: 10.1177/0962280206077743CrossRefGoogle ScholarPubMed
Dinan, T. G., Quigley, E. M., Ahmed, S. M., Scully, P., O'Brien, S., O'Mahony, L., … Keeling, P. W. (2006). Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: Plasma cytokines as a potential biomarker? Gastroenterology, 130(2), 304–311. doi: 10.1053/j.gastro.2005.11.033CrossRefGoogle ScholarPubMed
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010). A meta-analysis of cytokines in major depression. Biological Psychiatry, 67(5), 446–457. doi: 10.1016/j.biopsych.2009.09.033CrossRefGoogle ScholarPubMed
Drossman, D. A. (2005). Brain imaging and its implications for studying centrally targeted treatments in irritable bowel syndrome: A primer for gastroenterologists. Gut, 54(5), 569–573. doi: 10.1136/gut.2004.058446CrossRefGoogle ScholarPubMed
Drossman, D. A., Ringel, Y., Vogt, B. A., Leserman, J., Lin, W., Smith, J. K., & Whitehead, W. (2003). Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. Gastroenterology, 124(3), 754–761. doi: 10.1053/gast.2003.50103CrossRefGoogle Scholar
Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., … Parkes, M. (2021). Genome-wide analysis of 53400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. Nature Genetics, 53(11), 1543–1552. doi: 10.1038/s41588-021-00950-8CrossRefGoogle Scholar
Emerenziani, S., Guarino, M. P. L., Trillo Asensio, L. M., Altomare, A., Ribolsi, M., Balestrieri, P., & Cicala, M. (2019). Role of overweight and obesity in gastrointestinal disease. Nutrients, 12(1), 111. doi: 10.3390/nu12010111CrossRefGoogle ScholarPubMed
Fairfield, C. J., Drake, T. M., Pius, R., Bretherick, A. D., Campbell, A., Clark, D. W., … Spiliopoulou, A. (2022). Genome-wide association study of NAFLD using electronic health records. Hepatology Communications, 6(2), 297–308. doi: 10.1002/hep4.1805CrossRefGoogle ScholarPubMed
Fang, B., Yang, S., Liu, H., Zhang, Y., Xu, R., & Chen, G. (2019). Association between depression and subsequent peptic ulcer occurrence among older people living alone: A prospective study investigating the role of change in social engagement. Journal of Psychosomatic Research, 122, 94–103. doi: 10.1016/j.jpsychores.2019.04.002CrossRefGoogle ScholarPubMed
Farré, R., De Vos, R., Geboes, K., Verbecke, K., Vanden Berghe, P., Depoortere, I., … Sifrim, D. (2007). Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces. Gut, 56(9), 1191–1197. doi: 10.1136/gut.2006.113688CrossRefGoogle ScholarPubMed
Fewell, Z., Davey Smith, G., & Sterne, J. A. (2007). The impact of residual and unmeasured confounding in epidemiologic studies: A simulation study. American Journal of Epidemiology, 166(6), 646–655. doi: 10.1093/aje/kwm165CrossRefGoogle ScholarPubMed
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009). Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: A systematic review of the literature. The Journal of Clinical Psychiatry, 70(8), 1078–1090. doi: 10.4088/JCP.08r04505CrossRefGoogle ScholarPubMed
Hemani, G., Tilling, K., & Davey Smith, G. (2017). Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genetics, 13(11), e1007081. doi: 10.1371/journal.pgen.1007081CrossRefGoogle ScholarPubMed
Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., … Haycock, P. C. (2018). The MR-base platform supports systematic causal inference across the human phenome. eLife, 7, e34408. doi: 10.7554/eLife.34408CrossRefGoogle ScholarPubMed
Hsu, C. C., Hsu, Y. C., Chang, K. H., Lee, C. Y., Chong, L. W., Lin, C. L., … Kao, C. H. (2015). Depression and the risk of peptic ulcer disease: A nationwide population-based study. Medicine, 94(51), e2333. doi: 10.1097/md.0000000000002333CrossRefGoogle ScholarPubMed
Huang, X., Liu, X., & Yu, Y. (2017). Depression and chronic liver diseases: Are there shared underlying mechanisms? Frontiers in Molecular Neuroscience, 10, 134. doi: 10.3389/fnmol.2017.00134CrossRefGoogle ScholarPubMed
Janssens, K. A., Zijlema, W. L., Joustra, M. L., & Rosmalen, J. G. (2015). Mood and anxiety disorders in chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome: Results from the LifeLines cohort study. Psychosomatic Medicine, 77(4), 449–457. doi: 10.1097/psy.0000000000000161CrossRefGoogle ScholarPubMed
Jansson, C., Nordenstedt, H., Wallander, M. A., Johansson, S., Johnsen, R., Hveem, K., & Lagergren, J. (2007). Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study. Alimentary Pharmacology & Therapeutics, 26(5), 683–691. doi: 10.1111/j.1365-2036.2007.03411.xCrossRefGoogle ScholarPubMed
Jansson, C., Nordenstedt, H., Wallander, M. A., Johansson, S., Johnsen, R., Hveem, K., & Lagergren, J. (2009). A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 7(9), 960–965. doi: 10.1016/j.cgh.2009.03.007CrossRefGoogle ScholarPubMed
Johnston, B. T. (2005). Stress and heartburn. Journal of Psychosomatic Research, 59(6), 425–426. https://doi.org/10.1016/j.jpsychores.2005.05.011.CrossRefGoogle ScholarPubMed
Kamolz, T., & Velanovich, V. (2002). Psychological and emotional aspects of gastroesophageal reflux disease. Diseases of the Esophagus: official Journal of the International Society for Diseases of the Esophagus, 15(3), 199–203. doi: 10.1046/j.1442-2050.2002.00261.xCrossRefGoogle ScholarPubMed
Kim, D., Yoo, E. R., Li, A. A., Tighe, S. P., Cholankeril, G., Harrison, S. A., & Ahmed, A. (2019). Depression is associated with non-alcoholic fatty liver disease among adults in the United States. Alimentary Pharmacology & Therapeutics, 50(5), 590–598. doi: 10.1111/apt.15395CrossRefGoogle ScholarPubMed
Kim, J. Y., Kim, N., Seo, P. J., Lee, J. W., Kim, M. S., Kim, S. E., … Jung, H. C. (2013). Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. Journal of Neurogastroenterology and Motility, 19(3), 344–354. doi: 10.5056/jnm.2013.19.3.344CrossRefGoogle ScholarPubMed
Kim, S. Y., Kim, H. J., Lim, H., Kong, I. G., Kim, M., & Choi, H. G. (2018). Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort. Scientific Reports, 8(1), 11748. doi: 10.1038/s41598-018-29629-7CrossRefGoogle ScholarPubMed
Kim, S. Y., Min, C., Oh, D. J., & Choi, H. G. (2020). Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort. Scientific Reports, 10(1), 1749. doi: 10.1038/s41598-020-58783-0CrossRefGoogle ScholarPubMed
Kimura, Y., Kamiya, T., Senoo, K., Tsuchida, K., Hirano, A., Kojima, H., … Joh, T. (2016). Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients. Journal of Clinical Biochemistry and Nutrition, 59(1), 71–77. doi: 10.3164/jcbn.16-9CrossRefGoogle ScholarPubMed
Labenz, C., Huber, Y., Michel, M., Nagel, M., Galle, P. R., Kostev, K., & Schattenberg, J. M. (2020). Nonalcoholic fatty liver disease increases the risk of anxiety and depression. Hepatology Communications, 4(9), 1293–1301. doi: 10.1002/hep4.1541CrossRefGoogle ScholarPubMed
Lampa, J., Westman, M., Kadetoff, D., Agréus, A. N., Le Maître, E., Gillis-Haegerstrand, C., … Svensson, C. I. (2012). Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proceedings of the National Academy of Sciences of the United States of America, 109(31), 12728–12733. doi: 10.1073/pnas.1118748109CrossRefGoogle ScholarPubMed
Lee, K., Otgonsuren, M., Younoszai, Z., Mir, H. M., & Younossi, Z. M. (2013). Association of chronic liver disease with depression: A population-based study. Psychosomatics, 54(1), 52–59. doi: 10.1016/j.psym.2012.09.005CrossRefGoogle ScholarPubMed
Lee, S. P., Sung, I. K., Kim, J. H., Lee, S. Y., Park, H. S., & Shim, C. S. (2015). The effect of emotional stress and depression on the prevalence of digestive diseases. Journal of Neurogastroenterology and Motility, 21(2), 273–282. doi: 10.5056/jnm14116CrossRefGoogle ScholarPubMed
Lee, Y. B., Yu, J., Choi, H. H., Jeon, B. S., Kim, H. K., Kim, S. W., … Chae, H. S. (2017). The association between peptic ulcer diseases and mental health problems: A population-based study: A STROBE compliant article. Medicine, 96(34), e7828. doi: 10.1097/md.0000000000007828CrossRefGoogle ScholarPubMed
Li, J., Xu, K., Guo, Y., Chen, X., Li, G., Qi, L., & Che, X. (2022). Case evidence of repetitive transcranial magnetic stimulation in the management of refractory irritable bowel syndrome with comorbid depression. Brain Stimulation, 15(2), 434–436. doi: 10.1016/j.brs.2022.01.020CrossRefGoogle ScholarPubMed
Liu, W. Z., Xie, Y., Lu, H., Cheng, H., Zeng, Z. R., Zhou, L. Y., … Lu, N. H. (2018). Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection. Helicobacter, 23(2), e12475. doi: 10.1111/hel.12475CrossRefGoogle ScholarPubMed
Lyra, E. S. N. M., Lam, M. P., Soares, C. N., Munoz, D. P., Milev, R., & De Felice, F. G. (2019). Insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes. Frontiers in Psychiatry, 10, 57. doi: 10.3389/fpsyt.2019.00057CrossRefGoogle Scholar
Martín-Merino, E., Ruigómez, A., García Rodríguez, L. A., Wallander, M. A., & Johansson, S. (2010). Depression and treatment with antidepressants are associated with the development of gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 31(10), 1132–1140. doi: 10.1111/j.1365-2036.2010.04280.xCrossRefGoogle ScholarPubMed
Mayer, E. A., Craske, M., & Naliboff, B. D. (2001). Depression, anxiety, and the gastrointestinal system. The Journal of Clinical Psychiatry, 62(Suppl 8), 28–36, discussion 37.Google ScholarPubMed
Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023). The neurobiology of irritable bowel syndrome. Molecular Psychiatry. doi: 10.1038/s41380-023-01972-wCrossRefGoogle ScholarPubMed
Miller, A. H., Maletic, V., & Raison, C. L. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65(9), 732–741. doi: 10.1016/j.biopsych.2008.11.029CrossRefGoogle ScholarPubMed
Nikolova, V. L., Pelton, L., Moulton, C. D., Zorzato, D., Cleare, A. J., Young, A. H., & Stone, J. M. (2022). The prevalence and incidence of irritable bowel syndrome and inflammatory bowel disease in depression and bipolar disorder: A systematic review and meta-analysis. Psychosomatic Medicine, 84(3), 313–324. doi: 10.1097/psy.0000000000001046CrossRefGoogle ScholarPubMed
On, Z. X., Grant, J., Shi, Z., Taylor, A. W., Wittert, G. A., Tully, P. J., … Martin, S. (2017). The association between gastroesophageal reflux disease with sleep quality, depression, and anxiety in a cohort study of Australian men. Journal of Gastroenterology and Hepatology, 32(6), 1170–1177. doi: 10.1111/jgh.13650CrossRefGoogle Scholar
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., … Bercik, P. (2017). Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with irritable bowel syndrome. Gastroenterology, 153(2), 448–459, e448. doi:10.1053/j.gastro.2017.05.003CrossRefGoogle ScholarPubMed
Scott, K. M., Alonso, J., de Jonge, P., Viana, M. C., Liu, Z., O'Neill, S., … Kessler, R. C. (2013). Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys. Journal of Psychosomatic Research, 75(2), 121–127. doi: 10.1016/j.jpsychores.2013.04.007CrossRefGoogle ScholarPubMed
Shaheen, A. A., Kaplan, G. G., Sharkey, K. A., Lethebe, B. C., & Swain, M. G. (2021). Impact of major depression and antidepressant use on alcoholic and non-alcoholic fatty liver disease: A population-based study. Liver International: official Journal of the International Association for the Study of the Liver, 41(10), 2308–2317. doi: 10.1111/liv.14973CrossRefGoogle ScholarPubMed
Sibelli, A., Chalder, T., Everitt, H., Workman, P., Windgassen, S., & Moss-Morris, R. (2016). A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset. Psychological Medicine, 46(15), 3065–3080. doi: 10.1017/s0033291716001987CrossRefGoogle ScholarPubMed
Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Yarmolinsky, J., Davies, N. M., Swanson, S. A., … Richards, J. B. (2021). Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: The STROBE-MR statement. Jama, 326(16), 1614–1621. doi: 10.1001/jama.2021.18236CrossRefGoogle ScholarPubMed
Smith, G. D., & Ebrahim, S. (2003). ‘Mendelian randomization’: Can genetic epidemiology contribute to understanding environmental determinants of disease? International Journal of Epidemiology, 32(1), 1–22. doi: 10.1093/ije/dyg070CrossRefGoogle ScholarPubMed
Sugimoto, M., Yamaoka, Y., & Furuta, T. (2010). Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer. World Journal of Gastroenterology, 16(10), 1188–1200. doi: 10.3748/wjg.v16.i10.1188CrossRefGoogle ScholarPubMed
Takajo, T., Tomita, K., Tsuchihashi, H., Enomoto, S., Tanichi, M., Toda, H., … Hokari, R. (2019). Depression promotes the onset of irritable bowel syndrome through unique dysbiosis in rats. Gut and Liver, 13(3), 325–332. doi: 10.5009/gnl18296CrossRefGoogle ScholarPubMed
Tan, X., Pei, W., Xie, C., Wang, Z., Liu, J., Cheng, Y., … Li, J. (2021). Tongxie anchang decoction relieves visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats by regulating the NGF/TrkA signaling pathway. Evidence-Based Complementary and Alternative Medicine: eCAM, 2021, 6679348. doi: 10.1155/2021/6679348CrossRefGoogle ScholarPubMed
Tillisch, K. (2014). The effects of gut microbiota on CNS function in humans. Gut Microbes, 5(3), 404–410. doi: 10.4161/gmic.29232CrossRefGoogle ScholarPubMed
Tomeno, W., Kawashima, K., Yoneda, M., Saito, S., Ogawa, Y., Honda, Y., … Nakajima, A. (2015). Non-alcoholic fatty liver disease comorbid with major depressive disorder: The pathological features and poor therapeutic efficacy. Journal of Gastroenterology and Hepatology, 30(6), 1009–1014. doi: 10.1111/jgh.12897CrossRefGoogle ScholarPubMed
Tyrrell, J., Mulugeta, A., Wood, A. R., Zhou, A., Beaumont, R. N., Tuke, M. A., … Hyppönen, E. (2019). Using genetics to understand the causal influence of higher BMI on depression. International Journal of Epidemiology, 48(3), 834–848. doi: 10.1093/ije/dyy223CrossRefGoogle ScholarPubMed
Verne, G. N., & Sninsky, C. A. (1998). Diabetes and the gastrointestinal tract. Gastroenterology Clinics of North America, 27(4), 861–874. https://doi.org/10.1016/S0889-8553(05)70035–2.CrossRefGoogle ScholarPubMed
von Hippel, P. T. (2015). The heterogeneity statistic I(2) can be biased in small meta-analyses. BMC Medical Research Methodology, 15, 35. doi: 10.1186/s12874-015-0024-zCrossRefGoogle ScholarPubMed
Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., … Sullivan, P. F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50(5), 668–681. doi: 10.1038/s41588-018-0090-3CrossRefGoogle ScholarPubMed
Wu, C. L., Chen, C. L., & Wen, S. H. (2021a). Profile of the change in depression during proton-pump inhibitor therapy in patients with gastroesophageal reflux disease: Influence of the mucosal break. International Journal of Environmental Research and Public Health, 18(11), 5964. doi: 10.3390/ijerph18115964CrossRefGoogle ScholarPubMed
Wu, Y., Murray, G. K., Byrne, E. M., Sidorenko, J., Visscher, P. M., & Wray, N. R. (2021b). GWAS Of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. Nature Communications, 12(1), 1146. doi: 10.1038/s41467-021-21280-7CrossRefGoogle ScholarPubMed
Yao, Y., Xu, Y., Cai, Z., Liu, Q., Ma, Y., Li, A. N., … Li, M. D. (2021). Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression. Psychological Medicine, 51(11), 1870–1879. doi: 10.1017/s003329172000063xCrossRefGoogle ScholarPubMed
You, Z. H., Perng, C. L., Hu, L. Y., Lu, T., Chen, P. M., Yang, A. C., … Chen, H. J. (2015). Risk of psychiatric disorders following gastroesophageal reflux disease: A nationwide population-based cohort study. European Journal of Internal Medicine, 26(7), 534–539. doi: 10.1016/j.ejim.2015.05.005CrossRefGoogle ScholarPubMed
Youssef, N. A., Abdelmalek, M. F., Binks, M., Guy, C. D., Omenetti, A., Smith, A. D., … Suzuki, A. (2013). Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease. Liver International: Official Journal of the International Association for the Study of the Liver, 33(7), 1062–1070. doi: 10.1111/liv.12165CrossRefGoogle ScholarPubMed
Zamani, M., Alizadeh-Tabari, S., & Zamani, V. (2019). Systematic review with meta-analysis: The prevalence of anxiety and depression in patients with irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 50(2), 132–143. doi: 10.1111/apt.15325CrossRefGoogle ScholarPubMed
Zhu, F., Tu, H., & Chen, T. (2022). The microbiota-gut-brain axis in depression: The potential pathophysiological mechanisms and microbiota combined antidepression effect. Nutrients, 14(10), 2081. doi: 10.3390/nu14102081CrossRefGoogle ScholarPubMed
Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W. (2017). Microbiota-gut-brain axis and the central nervous system. Oncotarget, 8(32), 53829–53838. doi: 10.18632/oncotarget.17754CrossRefGoogle ScholarPubMed
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