1 Introduction
 Let 
 $\mathcal {D}_M$
 be the Dirac operator on an odd-dimensional locally compact smooth spin manifold M, which determines the K-homology fundamental class
$\mathcal {D}_M$
 be the Dirac operator on an odd-dimensional locally compact smooth spin manifold M, which determines the K-homology fundamental class 
 $[\mathcal {D}_M] \in K_1(M)$
. If
$[\mathcal {D}_M] \in K_1(M)$
. If 
 $\Sigma _M \in K^1(M)$
 is any element in the K-theory of M, there is a natural pairing
$\Sigma _M \in K^1(M)$
 is any element in the K-theory of M, there is a natural pairing 
 $\langle ~,~\rangle \colon K^1(M) \times K_1(M) \to \mathbb {Z}$
 of K-theory with K-homology, often referred to as the index pairing, which yields an integer
$\langle ~,~\rangle \colon K^1(M) \times K_1(M) \to \mathbb {Z}$
 of K-theory with K-homology, often referred to as the index pairing, which yields an integer 
 $$\begin{align*}\big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle \in \mathbb{Z}. \end{align*}$$
$$\begin{align*}\big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle \in \mathbb{Z}. \end{align*}$$
We now wish to compute this integer in terms of an index pairing on a suitable hypersurface 
 $N \subset M$
 of codimension one. Assume that
$N \subset M$
 of codimension one. Assume that 
 $U\subset M$
 is an open subset with compact closure
$U\subset M$
 is an open subset with compact closure 
 $K = \overline {U}$
 and smooth boundary
$K = \overline {U}$
 and smooth boundary 
 $N = \partial U$
. Consider the natural map
$N = \partial U$
. Consider the natural map 
 ${\iota _U}^* \colon K_1(M) \to K_1(U)$
 which sends
${\iota _U}^* \colon K_1(M) \to K_1(U)$
 which sends 
 $[\mathcal {D}_M]$
 to the class
$[\mathcal {D}_M]$
 to the class 
 $[\mathcal {D}_U]$
 of the restriction of the Dirac operator to U. The K-homology boundary map
$[\mathcal {D}_U]$
 of the restriction of the Dirac operator to U. The K-homology boundary map 
 $$\begin{align*}\partial \colon K_1(U) \to K_0(\partial U) \end{align*}$$
$$\begin{align*}\partial \colon K_1(U) \to K_0(\partial U) \end{align*}$$
sends the class 
 $[\mathcal {D}_U]$
 to the class
$[\mathcal {D}_U]$
 to the class 
 $[\mathcal {D}_{\partial U}]$
 of the Dirac operator on the boundary
$[\mathcal {D}_{\partial U}]$
 of the Dirac operator on the boundary 
 $\partial U$
.
$\partial U$
.
 Now suppose that the K-theory class 
 $\Sigma _M$
 is the image of a class
$\Sigma _M$
 is the image of a class 
 $\Sigma _U \in K^1(U)$
 under the natural map
$\Sigma _U \in K^1(U)$
 under the natural map 
 ${\iota _U}_* \colon K^1(U) \to K^1(M)$
. Suppose furthermore that
${\iota _U}_* \colon K^1(U) \to K^1(M)$
. Suppose furthermore that 
 $\Sigma _U$
 is the image of a class
$\Sigma _U$
 is the image of a class 
 $\Sigma _{\partial U} \in K^0(\partial U)$
 under the K-theory boundary map
$\Sigma _{\partial U} \in K^0(\partial U)$
 under the K-theory boundary map 
 $\partial \colon K^0(\partial U) \to K^1(U)$
. Then by naturality, we have the equalities
$\partial \colon K^0(\partial U) \to K^1(U)$
. Then by naturality, we have the equalities 
 $$ \begin{align*} \big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle &= \big\langle {\iota_U}_*\circ\partial(\Sigma_{\partial U}) , [\mathcal{D}_M] \big\rangle = \big\langle \partial(\Sigma_{\partial U}) , {\iota_U}_*([\mathcal{D}_M]) \big\rangle \\ &= \big\langle \Sigma_{\partial U} , \partial\circ{\iota_U}^*([\mathcal{D}_M]) \big\rangle = \big\langle \Sigma_{\partial U} , [\mathcal{D}_{\partial U}] \big\rangle. \end{align*} $$
$$ \begin{align*} \big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle &= \big\langle {\iota_U}_*\circ\partial(\Sigma_{\partial U}) , [\mathcal{D}_M] \big\rangle = \big\langle \partial(\Sigma_{\partial U}) , {\iota_U}_*([\mathcal{D}_M]) \big\rangle \\ &= \big\langle \Sigma_{\partial U} , \partial\circ{\iota_U}^*([\mathcal{D}_M]) \big\rangle = \big\langle \Sigma_{\partial U} , [\mathcal{D}_{\partial U}] \big\rangle. \end{align*} $$
 To summarise the preceding argument, if there exists a class 
 $\Sigma _{\partial U} \in K^1(\partial U)$
 with
$\Sigma _{\partial U} \in K^1(\partial U)$
 with 
 $\Sigma _M = {\iota _U}_*\circ \partial (\Sigma _{\partial U})$
, then the index pairing on the locally compact manifold M can be computed from an index pairing on the compact hypersurface
$\Sigma _M = {\iota _U}_*\circ \partial (\Sigma _{\partial U})$
, then the index pairing on the locally compact manifold M can be computed from an index pairing on the compact hypersurface 
 $\partial U$
:
$\partial U$
: 
 $$ \begin{align} \big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle = \big\langle \Sigma_{\partial U} , [\mathcal{D}_{\partial U}] \big\rangle. \end{align} $$
$$ \begin{align} \big\langle \Sigma_M , [\mathcal{D}_M] \big\rangle = \big\langle \Sigma_{\partial U} , [\mathcal{D}_{\partial U}] \big\rangle. \end{align} $$
 There are two (at first sight rather different) instances in the literature where such a computation has been made. The first instance is in the case of Dirac-Schrödinger (or Callias-type) operators. These are operators of the form 
 $\mathcal {D}_M-i\mathcal {S}$
, where the ‘potential’
$\mathcal {D}_M-i\mathcal {S}$
, where the ‘potential’ 
 $\mathcal {S}$
 is a self-adjoint endomorphism on some auxiliary vector bundle (of finite rank) over M. Assuming that
$\mathcal {S}$
 is a self-adjoint endomorphism on some auxiliary vector bundle (of finite rank) over M. Assuming that 
 $\mathcal {S}$
 is invertible outside of
$\mathcal {S}$
 is invertible outside of 
 $U\subset M$
, the Dirac-Schrödinger operator
$U\subset M$
, the Dirac-Schrödinger operator 
 $\mathcal {D}_M-i\mathcal {S}$
 is Fredholm, and its index computes the index pairing of the K-theory class of the potential with the K-homology class of the Dirac operator:
$\mathcal {D}_M-i\mathcal {S}$
 is Fredholm, and its index computes the index pairing of the K-theory class of the potential with the K-homology class of the Dirac operator: 
 $$\begin{align*}{\mathrm{Index}}(\mathcal{D}_M-i\mathcal{S}) = \big\langle [\mathcal{S}] , [\mathcal{D}_M] \big\rangle \in \mathbb{Z}. \end{align*}$$
$$\begin{align*}{\mathrm{Index}}(\mathcal{D}_M-i\mathcal{S}) = \big\langle [\mathcal{S}] , [\mathcal{D}_M] \big\rangle \in \mathbb{Z}. \end{align*}$$
The invertibility of 
 $\mathcal {S}$
 outside U ensures that
$\mathcal {S}$
 outside U ensures that 
 $[\mathcal {S}] = {\iota _U}_*([\mathcal {S}|_U])$
. Moreover, since we may perturb the potential on a compact subset without changing its K-theory class, and since
$[\mathcal {S}] = {\iota _U}_*([\mathcal {S}|_U])$
. Moreover, since we may perturb the potential on a compact subset without changing its K-theory class, and since 
 $\overline {U}$
 is compact, we note that
$\overline {U}$
 is compact, we note that 
 $j_*([\mathcal {S}|_U]) = [\mathcal {S}|_{\overline {U}}] = 0 \in K^1(\overline {U})$
, where
$j_*([\mathcal {S}|_U]) = [\mathcal {S}|_{\overline {U}}] = 0 \in K^1(\overline {U})$
, where 
 $j_* \colon K^1(U) \to K^1(\overline {U})$
 is induced from the inclusion
$j_* \colon K^1(U) \to K^1(\overline {U})$
 is induced from the inclusion 
 $U\hookrightarrow \overline {U}$
. By exactness of the sequence
$U\hookrightarrow \overline {U}$
. By exactness of the sequence 
 $$\begin{align*}K^0(\partial U) \xrightarrow{\partial} K^1(U) \xrightarrow{j_*} K^1(\overline{U}) , \end{align*}$$
$$\begin{align*}K^0(\partial U) \xrightarrow{\partial} K^1(U) \xrightarrow{j_*} K^1(\overline{U}) , \end{align*}$$
we therefore know that 
 $[\mathcal {S}|_U] = \partial (\Sigma _{\partial U})$
 for some
$[\mathcal {S}|_U] = \partial (\Sigma _{\partial U})$
 for some 
 $\Sigma _{\partial U} \in K^0(\partial U)$
. In fact, as we will see in Corollary 3.11, we can explicitly identify
$\Sigma _{\partial U} \in K^0(\partial U)$
. In fact, as we will see in Corollary 3.11, we can explicitly identify 
 $\Sigma _{\partial U}$
 as the K-theory class of the vector bundle
$\Sigma _{\partial U}$
 as the K-theory class of the vector bundle 
 $V_+$
 over
$V_+$
 over 
 $\partial U$
 obtained from the positive eigenspace of the invertible self-adjoint endomorphism
$\partial U$
 obtained from the positive eigenspace of the invertible self-adjoint endomorphism 
 $\mathcal {S}|_{\partial U}$
. The pairing
$\mathcal {S}|_{\partial U}$
. The pairing 
 $\langle [V_+] , [\mathcal {D}_{\partial U}] \rangle $
 can be computed as the index of the operator
$\langle [V_+] , [\mathcal {D}_{\partial U}] \rangle $
 can be computed as the index of the operator 
 $(\mathcal {D}_{\partial U})^+_+$
, which is obtained by twisting the chiral Dirac operator on
$(\mathcal {D}_{\partial U})^+_+$
, which is obtained by twisting the chiral Dirac operator on 
 $\partial U$
 with the vector bundle
$\partial U$
 with the vector bundle 
 $V_+$
. The equality (1.1) therefore yields
$V_+$
. The equality (1.1) therefore yields 
 $$ \begin{align} {\mathrm{Index}}(\mathcal{D}_M-i\mathcal{S}) = {\mathrm{Index}}(\mathcal{D}_{\partial U})^+_+. \end{align} $$
$$ \begin{align} {\mathrm{Index}}(\mathcal{D}_M-i\mathcal{S}) = {\mathrm{Index}}(\mathcal{D}_{\partial U})^+_+. \end{align} $$
This result is known as the Callias Theorem; the first version was proven by Callias [Reference CalliasCal78] on Euclidean space, and it has subsequently been generalised by various authors (see, for instance, [Reference AnghelAng90, Reference Brüning and MoscoviciBM92, Reference AnghelAng93, Reference RådeRåd94, Reference BunkeBun95, Reference KucerovskyKuc01, Reference Gesztesy and WaurickGW16]).
 The second instance of Equation (1.1) appears in the study of spectral flow. Consider a ‘sufficiently continuous’ family of self-adjoint Fredholm operators 
 $\{\mathcal {S}(x)\}_{x\in [0,1]}$
 with invertible endpoints and with common domain on a Hilbert space
$\{\mathcal {S}(x)\}_{x\in [0,1]}$
 with invertible endpoints and with common domain on a Hilbert space 
 $\mathcal {H}$
, such that
$\mathcal {H}$
, such that 
 $\mathcal {S}(x)$
 is a relatively compact perturbation of
$\mathcal {S}(x)$
 is a relatively compact perturbation of 
 $\mathcal {S}(0)$
 (for each
$\mathcal {S}(0)$
 (for each 
 $x\in [0,1]$
). Then the spectral flow depends only on the endpoints and is given by (see [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Theorem 3.6] and [Reference Wahl, Burghelea, Melrose, Mishchenko and TroitskyWah08, Proposition 2.5])
$x\in [0,1]$
). Then the spectral flow depends only on the endpoints and is given by (see [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Theorem 3.6] and [Reference Wahl, Burghelea, Melrose, Mishchenko and TroitskyWah08, Proposition 2.5]) 
 $$ \begin{align} \mathrm{sf}\big(\{\mathcal{S}(x)\}_{x\in[0,1]}\big) = {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big). \end{align} $$
$$ \begin{align} \mathrm{sf}\big(\{\mathcal{S}(x)\}_{x\in[0,1]}\big) = {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big). \end{align} $$
Here, the left-hand side is the spectral flow of the family 
 $\{\mathcal {S}(x)\}_{x\in [0,1]}$
, and the right-hand side is given by the relative index of the pair of positive spectral projections associated to
$\{\mathcal {S}(x)\}_{x\in [0,1]}$
, and the right-hand side is given by the relative index of the pair of positive spectral projections associated to 
 $\mathcal {S}(1)$
 and
$\mathcal {S}(1)$
 and 
 $\mathcal {S}(0)$
. To view this equality in the form of Equation (1.1), let
$\mathcal {S}(0)$
. To view this equality in the form of Equation (1.1), let 
 $M=\mathbb {R}$
,
$M=\mathbb {R}$
, 
 $U=(0,1)$
, and
$U=(0,1)$
, and 
 $N=\partial U=\{0\}\cup \{1\}$
, and extend
$N=\partial U=\{0\}\cup \{1\}$
, and extend 
 $\mathcal {S}$
 to a family on
$\mathcal {S}$
 to a family on 
 $\mathbb {R}$
. By the well-known ‘index = spectral flow’ equality of Robbin–Salamon (see, for example, [Reference Robbin and SalamonRS95, Reference WahlWah07, Reference Azzali and WahlAW11] and [Reference van den DungenDun19, Corollary 5.16]), the spectral flow can be described as an index pairing on
$\mathbb {R}$
. By the well-known ‘index = spectral flow’ equality of Robbin–Salamon (see, for example, [Reference Robbin and SalamonRS95, Reference WahlWah07, Reference Azzali and WahlAW11] and [Reference van den DungenDun19, Corollary 5.16]), the spectral flow can be described as an index pairing on 
 $\mathbb {R}$
:
$\mathbb {R}$
: 
 $$ \begin{align*} \text{sf}\big( \{\mathcal{S}(x)\}_{x\in\mathbb{R}} \big) &= {\mathrm{Index}}\big( \partial_x+\mathcal{S}(\cdot) \big) = \big\langle [\mathcal{S}(\cdot)] , [-i\partial_x] \big\rangle , \end{align*} $$
$$ \begin{align*} \text{sf}\big( \{\mathcal{S}(x)\}_{x\in\mathbb{R}} \big) &= {\mathrm{Index}}\big( \partial_x+\mathcal{S}(\cdot) \big) = \big\langle [\mathcal{S}(\cdot)] , [-i\partial_x] \big\rangle , \end{align*} $$
where 
 $-i\partial _x$
 is the standard Dirac operator on
$-i\partial _x$
 is the standard Dirac operator on 
 $\mathbb {R}$
. Moreover, the assumption that
$\mathbb {R}$
. Moreover, the assumption that 
 $\mathcal {S}(x)$
 is a relatively compact perturbation of
$\mathcal {S}(x)$
 is a relatively compact perturbation of 
 $\mathcal {S}(0)$
 (for each
$\mathcal {S}(0)$
 (for each 
 $x\in [0,1]$
), combined with the compactness of
$x\in [0,1]$
), combined with the compactness of 
 $[0,1]$
, implies that the operator
$[0,1]$
, implies that the operator 
 $\mathcal {S}(\cdot )|_{[0,1]}$
 is a relatively compact perturbation of a constant invertible family. It follows that
$\mathcal {S}(\cdot )|_{[0,1]}$
 is a relatively compact perturbation of a constant invertible family. It follows that 
 $j_*([\mathcal {S}(\cdot )|_{(0,1)}]) = 0 \in K^1([0,1])$
 (where
$j_*([\mathcal {S}(\cdot )|_{(0,1)}]) = 0 \in K^1([0,1])$
 (where 
 $j_*$
 is induced from the inclusion
$j_*$
 is induced from the inclusion 
 $(0,1)\hookrightarrow [0,1]$
), and therefore (by exactness, as in the case of Dirac-Schrödinger operators),
$(0,1)\hookrightarrow [0,1]$
), and therefore (by exactness, as in the case of Dirac-Schrödinger operators), 
 $[\mathcal {S}(\cdot )|_{(0,1)}] = \partial \big (\Sigma _{\{0\}\cup \{1\}}\big )$
 for some
$[\mathcal {S}(\cdot )|_{(0,1)}] = \partial \big (\Sigma _{\{0\}\cup \{1\}}\big )$
 for some 
 $\Sigma _{\{0\}\cup \{1\}} \in K^0(\{0\}\cup \{1\}) \simeq \mathbb {Z}\oplus \mathbb {Z}$
. We will see in Corollary 3.12 that the relative index on the right-hand side of Equation (1.3) is indeed obtained from an index pairing of
$\Sigma _{\{0\}\cup \{1\}} \in K^0(\{0\}\cup \{1\}) \simeq \mathbb {Z}\oplus \mathbb {Z}$
. We will see in Corollary 3.12 that the relative index on the right-hand side of Equation (1.3) is indeed obtained from an index pairing of 
 $\Sigma _{\{0\}\cup \{1\}}$
 with the K-homology element
$\Sigma _{\{0\}\cup \{1\}}$
 with the K-homology element 
 $[\mathcal {D}_{\{0\}\cup \{1\}}] \in K_0(\{0\}\cup \{1\})$
, where the latter can be identified with
$[\mathcal {D}_{\{0\}\cup \{1\}}] \in K_0(\{0\}\cup \{1\})$
, where the latter can be identified with 
 $(-1)\oplus 1\in \mathbb {Z}\oplus \mathbb {Z}$
.
$(-1)\oplus 1\in \mathbb {Z}\oplus \mathbb {Z}$
.
 Thus, we have seen that both the Callias Theorem (1.2) and the spectral flow result (1.3) can be viewed as a special case of the equality (1.1). Our goal in the present paper is to provide a common generalisation which unifies both these results. For this purpose, we now consider ‘generalised’ Dirac-Schrödinger operators, which are again operators of the form 
 $\mathcal {D}_M-i\mathcal {S}(\cdot )$
, where now the auxiliary vector bundle is of infinite rank, and the ‘potential’
$\mathcal {D}_M-i\mathcal {S}(\cdot )$
, where now the auxiliary vector bundle is of infinite rank, and the ‘potential’ 
 $\mathcal {S}(\cdot )$
 consists of a family of (unbounded) self-adjoint operators
$\mathcal {S}(\cdot )$
 consists of a family of (unbounded) self-adjoint operators 
 $\{\mathcal {S}(x)\}_{x\in M}$
 on a fixed Hilbert space
$\{\mathcal {S}(x)\}_{x\in M}$
 on a fixed Hilbert space 
 $\mathcal {H}$
. (In fact, instead of
$\mathcal {H}$
. (In fact, instead of 
 $\mathcal {H}$
, we will more generally consider a Hilbert
$\mathcal {H}$
, we will more generally consider a Hilbert 
 $C^*$
-module over some auxiliary
$C^*$
-module over some auxiliary 
 $C^*$
-algebra, but in this introduction, we limit our attention to the simpler case of a Hilbert space.) Such operators were studied in [Reference Kaad and LeschKL13, §8] for suitably differentiable potentials, and in [Reference van den DungenDun19] for continuous potentials. It is known that the pairing of the K-theory class of
$C^*$
-algebra, but in this introduction, we limit our attention to the simpler case of a Hilbert space.) Such operators were studied in [Reference Kaad and LeschKL13, §8] for suitably differentiable potentials, and in [Reference van den DungenDun19] for continuous potentials. It is known that the pairing of the K-theory class of 
 $\mathcal {S}(\cdot )$
 with the K-homology class of
$\mathcal {S}(\cdot )$
 with the K-homology class of 
 $\mathcal {D}_M$
 still equals the index of the Dirac-Schrödinger operator ([Reference Kaad and LeschKL13, Theorem 1.2] and [Reference van den DungenDun19, Theorem 5.15]):
$\mathcal {D}_M$
 still equals the index of the Dirac-Schrödinger operator ([Reference Kaad and LeschKL13, Theorem 1.2] and [Reference van den DungenDun19, Theorem 5.15]): 
 $$\begin{align*}\big\langle [\mathcal{S}(\cdot)] , [\mathcal{D}_M] \big\rangle = {\mathrm{Index}}\left( \mathcal{D}-i\mathcal{S}(\cdot) \right). \end{align*}$$
$$\begin{align*}\big\langle [\mathcal{S}(\cdot)] , [\mathcal{D}_M] \big\rangle = {\mathrm{Index}}\left( \mathcal{D}-i\mathcal{S}(\cdot) \right). \end{align*}$$
Now, under the additional assumption that the potential 
 $\mathcal {S}(\cdot )$
 is given by a family of relatively compact perturbations (as in the case of the spectral flow result (1.3)), we again find that
$\mathcal {S}(\cdot )$
 is given by a family of relatively compact perturbations (as in the case of the spectral flow result (1.3)), we again find that 
 $[\mathcal {S}(\cdot )] = {\iota _U}_*\circ \partial (\Sigma _{\partial U})$
 for some K-theory class
$[\mathcal {S}(\cdot )] = {\iota _U}_*\circ \partial (\Sigma _{\partial U})$
 for some K-theory class 
 $\Sigma _{\partial U} \in K^0(\partial U)$
. Hence, Equation (1.1) applies, and to obtain our desired generalisation of the Callias Theorem, it remains only to identify the class
$\Sigma _{\partial U} \in K^0(\partial U)$
. Hence, Equation (1.1) applies, and to obtain our desired generalisation of the Callias Theorem, it remains only to identify the class 
 $\Sigma _{\partial U}$
. We will see that this class can again (as in the spectral flow case) be described as a relative index of positive spectral projections, and our generalised Callias Theorem then provides the equality (we refer to §3.2 for the precise statement)
$\Sigma _{\partial U}$
. We will see that this class can again (as in the spectral flow case) be described as a relative index of positive spectral projections, and our generalised Callias Theorem then provides the equality (we refer to §3.2 for the precise statement) 
 $$ \begin{align*} {\mathrm{Index}}\big(\mathcal{D}-i\mathcal{S}(\cdot)\big) = \big\langle {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) , [\mathcal{D}_N] \big\rangle. \end{align*} $$
$$ \begin{align*} {\mathrm{Index}}\big(\mathcal{D}-i\mathcal{S}(\cdot)\big) = \big\langle {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) , [\mathcal{D}_N] \big\rangle. \end{align*} $$
Let us provide a brief summary of the contents of this paper. We start in Section 2 with some background material, describing both the classical Callias Theorem as well as the study of the spectral flow for relatively compact perturbations (in particular, we prove Equation (1.3)). In Section 3, we describe our main assumptions, definitions and the main results (the proofs are postponed to later sections). In particular, we state in §3.2 our generalisation of the classical Callias Theorem and show in §3.3 that we recover the Callias Theorem (1.2) and the spectral flow result (1.3). The remaining sections are devoted to the proofs. In Section 4, we first consider generalised Dirac-Schrödinger operators. As an important tool, we present a relative index theorem for such operators in §4.1, under fairly general assumptions. §4.2 and §4.3 then provide sufficient conditions under which we can prove that a Dirac-Schrödinger operator is Fredholm, and that its index equals the pairing between the K-theory and K-homology classes. Section 5 finally provides the proof of the generalised Callias-type theorem.
 Throughout the body of this article, we will work with Hilbert 
 $C^*$
-modules over
$C^*$
-modules over 
 $C^*$
-algebras (rather than just Hilbert spaces). An important step in our main result is to ensure that the relative index is well-defined, for which we require several operator-theoretic facts that are known for operators on Hilbert spaces, but (to the author’s best knowledge) have not yet appeared in the literature for operators on Hilbert
$C^*$
-algebras (rather than just Hilbert spaces). An important step in our main result is to ensure that the relative index is well-defined, for which we require several operator-theoretic facts that are known for operators on Hilbert spaces, but (to the author’s best knowledge) have not yet appeared in the literature for operators on Hilbert 
 $C^*$
-modules. We therefore include an Appendix, in which we generalise several (partly well-known) operator-theoretic results from Hilbert spaces to Hilbert
$C^*$
-modules. We therefore include an Appendix, in which we generalise several (partly well-known) operator-theoretic results from Hilbert spaces to Hilbert 
 $C^*$
-modules. We mention here a few of these results, which may also be of independent interest:
$C^*$
-modules. We mention here a few of these results, which may also be of independent interest: 
- 
• The composition of a  $*$
-strongly convergent sequence of adjointable operators with a compact operator yields a norm-convergent sequence (Lemma A.1). $*$
-strongly convergent sequence of adjointable operators with a compact operator yields a norm-convergent sequence (Lemma A.1).
- 
• Let T be regular and self-adjoint. Then any relatively T-compact operator R is relatively T-bounded with arbitrarily small relative bound (Proposition A.6). Consequently, if R is symmetric, then  $T+R$
 is again regular and self-adjoint on $T+R$
 is again regular and self-adjoint on ${\mathrm {Dom}}(T)$
 (Proposition A.7). ${\mathrm {Dom}}(T)$
 (Proposition A.7).
- 
• Let T be regular and self-adjoint, and let R be symmetric and relatively T-compact. Let  $f\in C(\mathbb {R})$
 be a continuous function for which the limits $f\in C(\mathbb {R})$
 be a continuous function for which the limits $\lim _{x\to \pm \infty }f(x)$
 exist. Then $\lim _{x\to \pm \infty }f(x)$
 exist. Then $f(T+R)-f(T)$
 is compact (Proposition A.9). Furthermore, if T and $f(T+R)-f(T)$
 is compact (Proposition A.9). Furthermore, if T and $T+R$
 are both invertible, also $T+R$
 are both invertible, also $P_+(T+R)-P_+(T)$
 is compact (where $P_+(T+R)-P_+(T)$
 is compact (where $P_+(T)$
 denotes the positive spectral projection of T). $P_+(T)$
 denotes the positive spectral projection of T).
1.1 Notation
 Throughout this paper, let A be a 
 $\sigma $
-unital
$\sigma $
-unital 
 $C^*$
-algebra, and let E be a (possibly
$C^*$
-algebra, and let E be a (possibly 
 $\mathbb {Z}_2$
-graded) countably generated Hilbert
$\mathbb {Z}_2$
-graded) countably generated Hilbert 
 $C^*$
-module over A (or Hilbert A-module for short) with A-valued inner product
$C^*$
-module over A (or Hilbert A-module for short) with A-valued inner product 
 $\langle \cdot |\cdot \rangle $
. (The reader unfamiliar with
$\langle \cdot |\cdot \rangle $
. (The reader unfamiliar with 
 $C^*$
-modules may consider the special case
$C^*$
-modules may consider the special case 
 $A=\mathbb {C}$
, so that E is simply a separable Hilbert space. For an introduction to Hilbert
$A=\mathbb {C}$
, so that E is simply a separable Hilbert space. For an introduction to Hilbert 
 $C^*$
-modules, we refer to [Reference LanceLan95].) For the inner product of an element
$C^*$
-modules, we refer to [Reference LanceLan95].) For the inner product of an element 
 $\psi \in E$
 with itself, we use the convenient short-hand notation
$\psi \in E$
 with itself, we use the convenient short-hand notation 

The norm of 
 $\psi $
 is then given by
$\psi $
 is then given by  .
.
 The space of adjointable linear operators 
 $E\to E$
 is denoted by
$E\to E$
 is denoted by 
 $\mathcal {L}_A(E)$
. For any
$\mathcal {L}_A(E)$
. For any 
 $\psi ,\eta \in E$
, the rank-one operators
$\psi ,\eta \in E$
, the rank-one operators 
 $\theta _{\psi ,\eta }$
 are defined by
$\theta _{\psi ,\eta }$
 are defined by 
 $\theta _{\psi ,\eta }\xi := \psi \langle \eta |\xi \rangle $
 for
$\theta _{\psi ,\eta }\xi := \psi \langle \eta |\xi \rangle $
 for 
 $\xi \in E$
. The compact operators
$\xi \in E$
. The compact operators 
 $\mathcal {K}_A(E)$
 are given by the closure of the space of finite linear combinations of rank-one operators. For two Hilbert A-modules
$\mathcal {K}_A(E)$
 are given by the closure of the space of finite linear combinations of rank-one operators. For two Hilbert A-modules 
 $E_1$
 and
$E_1$
 and 
 $E_2$
, the adjointable linear operators
$E_2$
, the adjointable linear operators 
 $E_1\to E_2$
 are denoted by
$E_1\to E_2$
 are denoted by 
 $\mathcal {L}_A(E_1,E_2)$
.
$\mathcal {L}_A(E_1,E_2)$
.
 A densely defined operator S is called regular if S is closed, the adjoint 
 $S^*$
 is densely defined, and
$S^*$
 is densely defined, and 
 $1+S^*S$
 has dense range (note that on a Hilbert space, every closed operator is regular). A densely defined, closed, symmetric operator S is regular and self-adjoint if and only if the operators
$1+S^*S$
 has dense range (note that on a Hilbert space, every closed operator is regular). A densely defined, closed, symmetric operator S is regular and self-adjoint if and only if the operators 
 $S\pm i$
 are surjective [Reference LanceLan95, Lemma 9.8].
$S\pm i$
 are surjective [Reference LanceLan95, Lemma 9.8].
 Given a densely defined, symmetric operator S on E, we can equip 
 ${\mathrm {Dom}} S$
 with the graph inner product
${\mathrm {Dom}} S$
 with the graph inner product 
 $\langle \psi |\psi \rangle _S := \langle (S\pm i)\psi |(S\pm i)\psi \rangle = \langle \psi |\psi \rangle + \langle S\psi |S\psi \rangle $
. The graph norm of S is then defined as
$\langle \psi |\psi \rangle _S := \langle (S\pm i)\psi |(S\pm i)\psi \rangle = \langle \psi |\psi \rangle + \langle S\psi |S\psi \rangle $
. The graph norm of S is then defined as 
 $\|\psi \|_S := \big \|\langle \psi |\psi \rangle _S\big \|^{\frac 12} = \|(S\pm i)\psi \|$
.
$\|\psi \|_S := \big \|\langle \psi |\psi \rangle _S\big \|^{\frac 12} = \|(S\pm i)\psi \|$
.
2 Background
As described in the Introduction, our main theorem simultaneously generalises both the classical Callias Theorem (1.2) and the spectral flow equality (1.3). In this section, we will introduce both these results.
2.1 The classical Callias Theorem
 The ‘classical Callias Theorem’, which we aim to generalise, is a result which was first proven by Callias [Reference CalliasCal78] on Euclidean space, who proved that the index of a Dirac-Schrödinger operator 
 $\mathcal {D}-i\mathcal {S}$
 on
$\mathcal {D}-i\mathcal {S}$
 on 
 $\mathbb {R}^{2n+1}$
 can be computed on a sufficiently large sphere. This has become known as the Callias Theorem and has been generalised by various authors (see, for instance, [Reference AnghelAng90, Reference Brüning and MoscoviciBM92, Reference AnghelAng93, Reference RådeRåd94, Reference BunkeBun95, Reference KucerovskyKuc01, Reference Gesztesy and WaurickGW16]), replacing Euclidean space by larger classes of Riemannian manifolds and computing the index on a suitable hypersurface (which is the boundary of a compact subset). The Callias Theorem continues to be actively studied, with recent work considering, for instance, Callias-type operators on Lie manifolds [Reference Carvalho and NistorCN14], with degenerate potentials [Reference KottkeKot15], via cobordism invariance [Reference Braverman and ShiBS16], on manifolds with boundary [Reference ShiShi17], twisted by Hilbert
$\mathbb {R}^{2n+1}$
 can be computed on a sufficiently large sphere. This has become known as the Callias Theorem and has been generalised by various authors (see, for instance, [Reference AnghelAng90, Reference Brüning and MoscoviciBM92, Reference AnghelAng93, Reference RådeRåd94, Reference BunkeBun95, Reference KucerovskyKuc01, Reference Gesztesy and WaurickGW16]), replacing Euclidean space by larger classes of Riemannian manifolds and computing the index on a suitable hypersurface (which is the boundary of a compact subset). The Callias Theorem continues to be actively studied, with recent work considering, for instance, Callias-type operators on Lie manifolds [Reference Carvalho and NistorCN14], with degenerate potentials [Reference KottkeKot15], via cobordism invariance [Reference Braverman and ShiBS16], on manifolds with boundary [Reference ShiShi17], twisted by Hilbert 
 $C^*$
-bundles of finite type [Reference CecchiniCec20], and associated to abstract spectral triples [Reference Schulz-Baldes and StoiberSS23].
$C^*$
-bundles of finite type [Reference CecchiniCec20], and associated to abstract spectral triples [Reference Schulz-Baldes and StoiberSS23].
 We will cite here Anghel’s version [Reference AnghelAng93] of the Callias Theorem. Let M be a complete odd-dimensional oriented Riemannian manifold, and let 
 $\mathcal {D}$
 be a formally self-adjoint Dirac-type operator on a hermitian Clifford bundle
$\mathcal {D}$
 be a formally self-adjoint Dirac-type operator on a hermitian Clifford bundle 
 $\Sigma \to M$
. Let
$\Sigma \to M$
. Let 
 $\mathcal {S} = \mathcal {S}^* \in \Gamma ^\infty ({\mathrm {End}}\Sigma )$
 be a hermitian bundle endomorphism such that
$\mathcal {S} = \mathcal {S}^* \in \Gamma ^\infty ({\mathrm {End}}\Sigma )$
 be a hermitian bundle endomorphism such that 
 $\mathcal {S}$
 commutes with Clifford multiplication,
$\mathcal {S}$
 commutes with Clifford multiplication, 
 $\mathcal {S}$
 and
$\mathcal {S}$
 and 
 $[\mathcal {D},\mathcal {S}]$
 are uniformly bounded, and there exists a compact subset
$[\mathcal {D},\mathcal {S}]$
 are uniformly bounded, and there exists a compact subset 
 $K\subset M$
 such that
$K\subset M$
 such that 
 $\mathcal {S}$
 is uniformly invertible on the complement of K.
$\mathcal {S}$
 is uniformly invertible on the complement of K.
 Without loss of generality, assume that K has a smooth compact boundary N. On 
 $\Sigma _N := \Sigma |_N$
, we have a
$\Sigma _N := \Sigma |_N$
, we have a 
 $\mathbb {Z}_2$
-grading operator
$\mathbb {Z}_2$
-grading operator 
 $\Gamma _N$
 given by Clifford multiplication with the unit normal vector on N, which yields the decomposition
$\Gamma _N$
 given by Clifford multiplication with the unit normal vector on N, which yields the decomposition 
 $\Sigma _N = \Sigma _N^+\oplus \Sigma _N^-$
. Consider a ‘restriction’
$\Sigma _N = \Sigma _N^+\oplus \Sigma _N^-$
. Consider a ‘restriction’ 
 $\mathcal {D}_N$
 of
$\mathcal {D}_N$
 of 
 $\mathcal {D}$
 to
$\mathcal {D}$
 to 
 $\Sigma _N$
 (i.e., the principal symbol of
$\Sigma _N$
 (i.e., the principal symbol of 
 $\mathcal {D}_N$
 is obtained from the principal symbol of
$\mathcal {D}_N$
 is obtained from the principal symbol of 
 $\mathcal {D}$
 by restricting from
$\mathcal {D}$
 by restricting from 
 $TM$
 to
$TM$
 to 
 $TN$
), which anticommutes with
$TN$
), which anticommutes with 
 $\Gamma _N$
. Since
$\Gamma _N$
. Since 
 $\mathcal {D}_N$
 is elliptic and N is compact,
$\mathcal {D}_N$
 is elliptic and N is compact, 
 $\mathcal {D}_N$
 has compact resolvents. In particular,
$\mathcal {D}_N$
 has compact resolvents. In particular, 
 $\mathcal {D}_N$
 is Fredholm, and we obtain a K-homology class
$\mathcal {D}_N$
 is Fredholm, and we obtain a K-homology class 
 $[\mathcal {D}_N] \in K^0(C(N)) \equiv K_0(N)$
.
$[\mathcal {D}_N] \in K^0(C(N)) \equiv K_0(N)$
.
 Let 
 $\mathcal {S}_N$
 denote the restriction of
$\mathcal {S}_N$
 denote the restriction of 
 $\mathcal {S}$
 to
$\mathcal {S}$
 to 
 $\Sigma _N\to N$
. We define
$\Sigma _N\to N$
. We define 
 $\Sigma _{N+} := {\mathrm {Ran}} P_+(\mathcal {S}_N)$
 to be the image of the positive spectral projection of
$\Sigma _{N+} := {\mathrm {Ran}} P_+(\mathcal {S}_N)$
 to be the image of the positive spectral projection of 
 $\mathcal {S}_N$
, representing a K-theory class
$\mathcal {S}_N$
, representing a K-theory class 
 $[\Sigma _{N+}] \in K_0(C(N)) \equiv K^0(N)$
.
$[\Sigma _{N+}] \in K_0(C(N)) \equiv K^0(N)$
.
 Since 
 $\mathcal {S}$
 commutes with the Clifford multiplication,
$\mathcal {S}$
 commutes with the Clifford multiplication, 
 $\Gamma _N$
 is still a
$\Gamma _N$
 is still a 
 $\mathbb {Z}_2$
-grading on
$\mathbb {Z}_2$
-grading on 
 $\Sigma _{N+}$
 and yields the decomposition
$\Sigma _{N+}$
 and yields the decomposition 
 $\Sigma _{N+} = \Sigma _{N+}^+ \oplus \Sigma _{N+}^-$
. We will consider the Fredholm operator
$\Sigma _{N+} = \Sigma _{N+}^+ \oplus \Sigma _{N+}^-$
. We will consider the Fredholm operator 
 $$\begin{align*}(\mathcal{D}_N)_+^+ := \mathcal{D}_N|_{\Sigma_{N+}^+} \colon \Sigma_{N+}^+ \to \Sigma_{N+}^-. \end{align*}$$
$$\begin{align*}(\mathcal{D}_N)_+^+ := \mathcal{D}_N|_{\Sigma_{N+}^+} \colon \Sigma_{N+}^+ \to \Sigma_{N+}^-. \end{align*}$$
Theorem 2.1 [Reference AnghelAng93, Theorem 1.5].
Under the assumptions given above, we have the equalities
 $$\begin{align*}{\mathrm{Index}}\big(\mathcal{D}-i\mathcal{S}\big) = {\mathrm{Index}} \big(\mathcal{D}_N\big)_+^+ = [\Sigma_{N+}] \otimes_{C(N)} [\mathcal{D}_N] = \int_N \hat A(N) \wedge {\mathrm{ch}}(\Sigma_{N+}). \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big(\mathcal{D}-i\mathcal{S}\big) = {\mathrm{Index}} \big(\mathcal{D}_N\big)_+^+ = [\Sigma_{N+}] \otimes_{C(N)} [\mathcal{D}_N] = \int_N \hat A(N) \wedge {\mathrm{ch}}(\Sigma_{N+}). \end{align*}$$
 We note that, while Anghel’s theorem and proof focused on the first equality, the index of 
 $\big (\mathcal {D}_N\big )_+^+$
 realises the index pairing (Kasparov product) of the K-theory class
$\big (\mathcal {D}_N\big )_+^+$
 realises the index pairing (Kasparov product) of the K-theory class 
 $[\Sigma _{N+}]$
 with the K-homology class
$[\Sigma _{N+}]$
 with the K-homology class 
 $[\mathcal {D}_N]$
, and it can be computed as
$[\mathcal {D}_N]$
, and it can be computed as 
 $\int _N \hat A(N) \wedge {\mathrm {ch}}(\Sigma _{N+})$
 by the Atiyah–Singer Index Theorem [Reference Atiyah and SingerAS63].
$\int _N \hat A(N) \wedge {\mathrm {ch}}(\Sigma _{N+})$
 by the Atiyah–Singer Index Theorem [Reference Atiyah and SingerAS63].
2.2 Spectral flow
 Next, we will describe the spectral flow equality (1.3) from the Introduction in detail (see Proposition 2.8). First, we provide the relevant definitions in the context of Hilbert 
 $C^*$
-modules.
$C^*$
-modules.
 An adjointable operator 
 $F \in \mathcal {L}_A(E)$
 is called Fredholm if there exists a parametrix
$F \in \mathcal {L}_A(E)$
 is called Fredholm if there exists a parametrix 
 $G \in \mathcal {L}_A(E)$
 such that
$G \in \mathcal {L}_A(E)$
 such that 
 $GF - 1$
 and
$GF - 1$
 and 
 $FG - 1$
 are compact operators on E. If F is Fredholm, we denote by
$FG - 1$
 are compact operators on E. If F is Fredholm, we denote by 
 ${\mathrm {Index}}(F) \in K_0(A)$
 the
${\mathrm {Index}}(F) \in K_0(A)$
 the 
 $K_0(A)$
-valued index of F; for the definition of this index, we refer to [Reference van den DungenDun19, §2.2] and references therein.
$K_0(A)$
-valued index of F; for the definition of this index, we refer to [Reference van den DungenDun19, §2.2] and references therein.
2.2.1 The relative index of projections
 Consider two projections 
 $P,Q \in \mathcal {L}_A(E)$
. If the difference
$P,Q \in \mathcal {L}_A(E)$
. If the difference 
 $P-Q$
 is a compact operator on E, then the operator
$P-Q$
 is a compact operator on E, then the operator 
 $Q \colon {\mathrm {Ran}}(P) \to {\mathrm {Ran}}(Q)$
 is a Fredholm operator with parametrix
$Q \colon {\mathrm {Ran}}(P) \to {\mathrm {Ran}}(Q)$
 is a Fredholm operator with parametrix 
 $P \colon  {\mathrm {Ran}}(Q) \to  {\mathrm {Ran}}(P)$
.
$P \colon  {\mathrm {Ran}}(Q) \to  {\mathrm {Ran}}(P)$
.
Definition 2.2. For projections 
 $P,Q \in \mathcal {L}_A(E)$
 with
$P,Q \in \mathcal {L}_A(E)$
 with 
 $P-Q \in \mathcal {K}_A(E)$
, we define the relative index of
$P-Q \in \mathcal {K}_A(E)$
, we define the relative index of 
 $(P,Q)$
 by
$(P,Q)$
 by 
 $$\begin{align*}{\text{rel-ind}}(P,Q) := {\mathrm{Index}} \big( Q \colon {\mathrm{Ran}}(P) \to {\mathrm{Ran}}(Q) \big) \in K_0(A). \end{align*}$$
$$\begin{align*}{\text{rel-ind}}(P,Q) := {\mathrm{Index}} \big( Q \colon {\mathrm{Ran}}(P) \to {\mathrm{Ran}}(Q) \big) \in K_0(A). \end{align*}$$
For future reference, we record two important properties of the relative index:
Lemma 2.3 [Reference WahlWah07, §3.2].
- 
• (Additivity.) If  $P,Q,R \in \mathcal {L}_A(E)$
 are projections with $P,Q,R \in \mathcal {L}_A(E)$
 are projections with $P-Q$
 and $P-Q$
 and $Q-R$
 compact, then $Q-R$
 compact, then $$\begin{align*}{\text{rel-ind}}(P,R) = {\text{rel-ind}}(P,Q) + {\text{rel-ind}}(Q,R). \end{align*}$$ $$\begin{align*}{\text{rel-ind}}(P,R) = {\text{rel-ind}}(P,Q) + {\text{rel-ind}}(Q,R). \end{align*}$$
- 
• (Homotopy invariance.) If  $\{P_t\}_{t\in [0,1]}$
 and $\{P_t\}_{t\in [0,1]}$
 and $\{Q_t\}_{t\in [0,1]}$
 are strongly continuous paths of projections such that $\{Q_t\}_{t\in [0,1]}$
 are strongly continuous paths of projections such that $P_t-Q_t$
 is compact for each $P_t-Q_t$
 is compact for each $t\in [0,1]$
, then $t\in [0,1]$
, then $$\begin{align*}{\text{rel-ind}}(P_0,Q_0) = {\text{rel-ind}}(P_1,Q_1). \end{align*}$$ $$\begin{align*}{\text{rel-ind}}(P_0,Q_0) = {\text{rel-ind}}(P_1,Q_1). \end{align*}$$
Using the homotopy invariance of the relative index, we obtain the following:
Corollary 2.4. Let 
 $\{P_t\}_{t\in [0,1]}$
 be a strongly continuous family of projections on E, such that
$\{P_t\}_{t\in [0,1]}$
 be a strongly continuous family of projections on E, such that 
 $P_t-P_0$
 is compact for each
$P_t-P_0$
 is compact for each 
 $t\in [0,1]$
. Then rel-ind(P
0, P
1) = 0.
$t\in [0,1]$
. Then rel-ind(P
0, P
1) = 0.
2.2.2 The spectral flow
The notion of spectral flow for a path of self-adjoint operators (typically parametrised by the unit interval) was first defined by Atiyah and Lusztig, and it appeared in the work of Atiyah, Patodi and Singer [Reference Atiyah, Patodi and SingerAPS76, §7]. Heuristically, the spectral flow of a path of self-adjoint Fredholm operators counts the net number of eigenvalues which pass through zero. An analytic definition of the spectral flow of a path of self-adjoint Fredholm operators on a Hilbert space was given by Phillips in [Reference PhillipsPhi96]. An axiomatic study of the spectral flow was given by Lesch in [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05].
 For regular self-adjoint Fredholm operators on a Hilbert 
 $C^*$
-module, a general definition of spectral flow was given by Wahl in [Reference WahlWah07, §3], which we will largely follow here. However, we slightly adapt this definition by allowing the ‘trivialising operators’ (which appear in the definition of the spectral flow) to be possibly unbounded (rather than bounded, as in [Reference WahlWah07, §3]). This is made possible by Proposition A.9 and Corollary A.10 (generalising [Reference WahlWah07, Proposition 3.7]). For the definition and properties of relatively compact operators, we refer the reader to §A.3 in the Appendix.
$C^*$
-module, a general definition of spectral flow was given by Wahl in [Reference WahlWah07, §3], which we will largely follow here. However, we slightly adapt this definition by allowing the ‘trivialising operators’ (which appear in the definition of the spectral flow) to be possibly unbounded (rather than bounded, as in [Reference WahlWah07, §3]). This is made possible by Proposition A.9 and Corollary A.10 (generalising [Reference WahlWah07, Proposition 3.7]). For the definition and properties of relatively compact operators, we refer the reader to §A.3 in the Appendix.
Definition 2.5 (cf. [Reference WahlWah07, Definition 3.4]).
 Let 
 $\mathcal {D}$
 be a regular self-adjoint operator on E. A trivialising operator for
$\mathcal {D}$
 be a regular self-adjoint operator on E. A trivialising operator for 
 $\mathcal {D}$
 is a (densely defined) symmetric operator
$\mathcal {D}$
 is a (densely defined) symmetric operator 
 $\mathcal {B}$
 on E such that
$\mathcal {B}$
 on E such that 
 $\mathcal {B}$
 is relatively
$\mathcal {B}$
 is relatively 
 $\mathcal {D}$
-compact and
$\mathcal {D}$
-compact and 
 $\mathcal {D}+\mathcal {B}$
 is invertible.
$\mathcal {D}+\mathcal {B}$
 is invertible.
 Now let 
 $\mathcal {D}$
 be a regular self-adjoint Fredholm operator on E, and let
$\mathcal {D}$
 be a regular self-adjoint Fredholm operator on E, and let 
 $\mathcal {B}_0$
 and
$\mathcal {B}_0$
 and 
 $\mathcal {B}_1$
 be two trivialising operators for
$\mathcal {B}_1$
 be two trivialising operators for 
 $\mathcal {D}$
. By Corollary A.10, which generalises [Reference WahlWah07, Proposition 3.7], the difference of spectral projections
$\mathcal {D}$
. By Corollary A.10, which generalises [Reference WahlWah07, Proposition 3.7], the difference of spectral projections 
 $P_+(\mathcal {D}+\mathcal {B}_1) - P_+(\mathcal {D}+B_0)$
 is compact. Hence, we can define
$P_+(\mathcal {D}+\mathcal {B}_1) - P_+(\mathcal {D}+B_0)$
 is compact. Hence, we can define 
 $$ \begin{align} {\mathrm{ind}}(\mathcal{D},\mathcal{B}_0,\mathcal{B}_1) := {\text{rel-ind}}\big( P_+(\mathcal{D}+\mathcal{B}_1) , P_+(\mathcal{D}+B_0) \big). \end{align} $$
$$ \begin{align} {\mathrm{ind}}(\mathcal{D},\mathcal{B}_0,\mathcal{B}_1) := {\text{rel-ind}}\big( P_+(\mathcal{D}+\mathcal{B}_1) , P_+(\mathcal{D}+B_0) \big). \end{align} $$
Definition 2.6 (cf. [Reference WahlWah07, Definition 3.9]).
 Let X be a compact Hausdorff space, and consider a regular operator 
 $\mathcal {D}(\cdot ) = \{\mathcal {D}(x)\}_{x\in X}$
 on the Hilbert
$\mathcal {D}(\cdot ) = \{\mathcal {D}(x)\}_{x\in X}$
 on the Hilbert 
 $C(X,A)$
-module
$C(X,A)$
-module 
 $C(X,E)$
. A trivialising family for
$C(X,E)$
. A trivialising family for 
 $\{\mathcal {D}(x)\}_{x\in X}$
 is a family
$\{\mathcal {D}(x)\}_{x\in X}$
 is a family 
 $\{\mathcal {B}(x)\}_{x\in X}$
 of operators on E such that
$\{\mathcal {B}(x)\}_{x\in X}$
 of operators on E such that 
 $\mathcal {B}(\cdot )$
 is a trivialising operator for
$\mathcal {B}(\cdot )$
 is a trivialising operator for 
 $\mathcal {D}(\cdot )$
.
$\mathcal {D}(\cdot )$
.
 We say there exist locally trivialising families for 
 $\mathcal {D}(\cdot )$
 if for each
$\mathcal {D}(\cdot )$
 if for each 
 $x\in X$
 there exist a compact neighbourhood
$x\in X$
 there exist a compact neighbourhood 
 $O_x$
 of x and a trivialising family for
$O_x$
 of x and a trivialising family for 
 $\{\mathcal {D}(y)\}_{y\in O_x}$
.
$\{\mathcal {D}(y)\}_{y\in O_x}$
.
 We note that the existence of locally trivialising families for 
 $\{\mathcal {D}(x)\}_{x\in X}$
 then implies that
$\{\mathcal {D}(x)\}_{x\in X}$
 then implies that 
 $\mathcal {D}(\cdot )$
 is Fredholm (using compactness of X).
$\mathcal {D}(\cdot )$
 is Fredholm (using compactness of X).
Definition 2.7 (cf. [Reference WahlWah07, Definition 3.10]).
 Let 
 $\mathcal {D}(\cdot ) = \{\mathcal {D}(t)\}_{t\in [0,1]}$
 be a regular self-adjoint operator on the Hilbert
$\mathcal {D}(\cdot ) = \{\mathcal {D}(t)\}_{t\in [0,1]}$
 be a regular self-adjoint operator on the Hilbert 
 $C([0,1],A)$
-module
$C([0,1],A)$
-module 
 $C([0,1],E)$
, for which locally trivialising families exist. Let
$C([0,1],E)$
, for which locally trivialising families exist. Let 
 $0 = t_0 < t_1 < \ldots < t_n = 1$
 be such that there is a trivialising family
$0 = t_0 < t_1 < \ldots < t_n = 1$
 be such that there is a trivialising family 
 $\{\mathcal {B}^i(t)\}_{t\in [t_i,t_{i+1}]}$
 of
$\{\mathcal {B}^i(t)\}_{t\in [t_i,t_{i+1}]}$
 of 
 $\{\mathcal {D}(t)\}_{t\in [t_i,t_{i+1}]}$
 for each
$\{\mathcal {D}(t)\}_{t\in [t_i,t_{i+1}]}$
 for each 
 $i=0,\ldots ,n-1$
. Let
$i=0,\ldots ,n-1$
. Let 
 $\mathcal {A}_0$
 and
$\mathcal {A}_0$
 and 
 $\mathcal {A}_1$
 be trivialising operators of
$\mathcal {A}_1$
 be trivialising operators of 
 $\mathcal {D}(0)$
 and
$\mathcal {D}(0)$
 and 
 $\mathcal {D}(1)$
. Then we define
$\mathcal {D}(1)$
. Then we define 
 $$ \begin{align*} &\text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]}; \mathcal{A}_0,\mathcal{A}_1 \big) \\ &\qquad := {\mathrm{ind}}\big(\mathcal{D}(0),\mathcal{A}_0,\mathcal{B}^0(0)\big) + \sum_{i=1}^{n-1} {\mathrm{ind}}\big(\mathcal{D}(t_i),\mathcal{B}^{i-1}(t_i),\mathcal{B}^i(t_i)\big) + {\mathrm{ind}}\big(\mathcal{D}(1),\mathcal{B}^{n-1}(1),\mathcal{A}_1\big) \in K_0(A) , \end{align*} $$
$$ \begin{align*} &\text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]}; \mathcal{A}_0,\mathcal{A}_1 \big) \\ &\qquad := {\mathrm{ind}}\big(\mathcal{D}(0),\mathcal{A}_0,\mathcal{B}^0(0)\big) + \sum_{i=1}^{n-1} {\mathrm{ind}}\big(\mathcal{D}(t_i),\mathcal{B}^{i-1}(t_i),\mathcal{B}^i(t_i)\big) + {\mathrm{ind}}\big(\mathcal{D}(1),\mathcal{B}^{n-1}(1),\mathcal{A}_1\big) \in K_0(A) , \end{align*} $$
where 
 $ {\mathrm {ind}}$
 is defined in Equation (2.1). If we assume furthermore that the endpoints
$ {\mathrm {ind}}$
 is defined in Equation (2.1). If we assume furthermore that the endpoints 
 $\mathcal {D}(0)$
 and
$\mathcal {D}(0)$
 and 
 $\mathcal {D}(1)$
 are invertible, then the spectral flow of
$\mathcal {D}(1)$
 are invertible, then the spectral flow of 
 $\{\mathcal {D}(t)\}_{t\in [0,1]}$
 is defined by
$\{\mathcal {D}(t)\}_{t\in [0,1]}$
 is defined by 
 $$ \begin{align*} \text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]} \big) &:= \text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]}; 0,0 \big) \\ &= {\mathrm{ind}}\big(\mathcal{D}(0),0,\mathcal{B}^0(0)\big) + \sum_{i=1}^{n-1} {\mathrm{ind}}\big(\mathcal{D}(t_i),\mathcal{B}^{i-1}(t_i),\mathcal{B}^i(t_i)\big) + {\mathrm{ind}}\big(\mathcal{D}(1),\mathcal{B}^{n-1}(1),0\big). \end{align*} $$
$$ \begin{align*} \text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]} \big) &:= \text{sf}\big(\{\mathcal{D}(t)\}_{t\in[0,1]}; 0,0 \big) \\ &= {\mathrm{ind}}\big(\mathcal{D}(0),0,\mathcal{B}^0(0)\big) + \sum_{i=1}^{n-1} {\mathrm{ind}}\big(\mathcal{D}(t_i),\mathcal{B}^{i-1}(t_i),\mathcal{B}^i(t_i)\big) + {\mathrm{ind}}\big(\mathcal{D}(1),\mathcal{B}^{n-1}(1),0\big). \end{align*} $$
 As in [Reference WahlWah07], the definition of the spectral flow is independent of the choice of subdivision and the choice of trivialising families 
 $\{\mathcal {B}^i(t)\}_{t\in [t_i,t_{i+1}]}$
. In particular, using [Reference WahlWah07, Lemma 3.5], we may choose the trivialising families to be bounded, and thus, we recover the definition of the spectral flow given in [Reference WahlWah07, Definition 3.10].
$\{\mathcal {B}^i(t)\}_{t\in [t_i,t_{i+1}]}$
. In particular, using [Reference WahlWah07, Lemma 3.5], we may choose the trivialising families to be bounded, and thus, we recover the definition of the spectral flow given in [Reference WahlWah07, Definition 3.10].
2.2.3 Spectral flow for relatively compact perturbations
For our attempt to generalise the Callias Theorem to the case of infinite-rank bundles, we take some inspiration from the study of spectral flow. In particular, the following result motivates the idea that a Callias-type theorem should hold for generalised Dirac-Schrödinger operators whenever the ‘potential’ is given by a family of relatively compact perturbations.
Proposition 2.8 (cf. [Reference WahlWah07, Example in §3.4]).
 Let 
 $\mathcal {T}(\cdot ) = \{\mathcal {T}(t)\}_{t\in [0,1]}$
 be a regular self-adjoint operator on the Hilbert
$\mathcal {T}(\cdot ) = \{\mathcal {T}(t)\}_{t\in [0,1]}$
 be a regular self-adjoint operator on the Hilbert 
 $C([0,1],A)$
-module
$C([0,1],A)$
-module 
 $C([0,1],E)$
, such that
$C([0,1],E)$
, such that 
- 
• the endpoints  $\mathcal {T}(0)$
 and $\mathcal {T}(0)$
 and $\mathcal {T}(1)$
 are invertible; $\mathcal {T}(1)$
 are invertible;
- 
•  $\mathcal {T}(t) \colon  {\mathrm {Dom}}\mathcal {T}(0) \to E$
 depends norm-continuously on t; and $\mathcal {T}(t) \colon  {\mathrm {Dom}}\mathcal {T}(0) \to E$
 depends norm-continuously on t; and
- 
•  $\mathcal {T}(t)-\mathcal {T}(0)$
 is relatively $\mathcal {T}(t)-\mathcal {T}(0)$
 is relatively $\mathcal {T}(0)$
-compact for each $\mathcal {T}(0)$
-compact for each $t\in [0,1]$
. $t\in [0,1]$
.
Then the following statements hold:
- 
1. There exists a trivialising family for  $\{\mathcal {T}(t)\}_{t\in [0,1]}$
. $\{\mathcal {T}(t)\}_{t\in [0,1]}$
.
- 
2. We have the equality (2.2) $$ \begin{align} \text{sf}\big(\{\mathcal{T}(t)\}_{t\in[0,1]} \big) &= {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(0)) \big). \end{align} $$ $$ \begin{align} \text{sf}\big(\{\mathcal{T}(t)\}_{t\in[0,1]} \big) &= {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(0)) \big). \end{align} $$
Proof.
- 
1. We observe that the family of operators  $\mathcal {B}(t) := \mathcal {T}(0)-\mathcal {T}(t)$
 ( $\mathcal {B}(t) := \mathcal {T}(0)-\mathcal {T}(t)$
 ( $t\in [0,1]$
) yields a densely defined symmetric operator $t\in [0,1]$
) yields a densely defined symmetric operator $\mathcal {B}(\cdot )$
 on $\mathcal {B}(\cdot )$
 on $C([0,1],E)$
, such that $C([0,1],E)$
, such that $\mathcal {T}(\cdot )+\mathcal {B}(\cdot )$
 is invertible. Moreover, $\mathcal {T}(\cdot )+\mathcal {B}(\cdot )$
 is invertible. Moreover, $\mathcal {B}(t) \big (\mathcal {T}(t)\pm i\big )^{-1}$
 is compact for each $\mathcal {B}(t) \big (\mathcal {T}(t)\pm i\big )^{-1}$
 is compact for each $t\in [0,1]$
 (where we use that $t\in [0,1]$
 (where we use that $ {\mathrm {Dom}}\mathcal {T}(t)= {\mathrm {Dom}}\mathcal {T}(0)$
 by Proposition A.7). Since $ {\mathrm {Dom}}\mathcal {T}(t)= {\mathrm {Dom}}\mathcal {T}(0)$
 by Proposition A.7). Since $\big (\mathcal {T}(t)\pm i\big ) \big (\mathcal {T}(0)\pm i)^{-1}$
 is norm-continuous in t, also the family of inverses $\big (\mathcal {T}(t)\pm i\big ) \big (\mathcal {T}(0)\pm i)^{-1}$
 is norm-continuous in t, also the family of inverses $\big (\mathcal {T}(0)\pm i\big ) \big (\mathcal {T}(t)\pm i)^{-1}$
 is norm-continuous, and therefore, $\big (\mathcal {T}(0)\pm i\big ) \big (\mathcal {T}(t)\pm i)^{-1}$
 is norm-continuous, and therefore, $\mathcal {B}(t) \big (\mathcal {T}(t)\pm i\big )^{-1}$
 is norm-continuous in t. This shows that $\mathcal {B}(t) \big (\mathcal {T}(t)\pm i\big )^{-1}$
 is norm-continuous in t. This shows that $\mathcal {B}(\cdot )$
 is relatively $\mathcal {B}(\cdot )$
 is relatively $\mathcal {T}(\cdot )$
-compact. Thus, $\mathcal {T}(\cdot )$
-compact. Thus, $\mathcal {B}(\cdot )$
 is a trivialising operator for $\mathcal {B}(\cdot )$
 is a trivialising operator for $\mathcal {T}(\cdot )$
. $\mathcal {T}(\cdot )$
.
- 
2. We can insert the trivialising family  $\{\mathcal {B}(t)\}_{t\in [0,1]}$
 from the first statement into Definition 2.7 to obtain where we used that $\{\mathcal {B}(t)\}_{t\in [0,1]}$
 from the first statement into Definition 2.7 to obtain where we used that $$ \begin{align*} &\text{sf}\big(\{\mathcal{T}(t)\}_{t\in[0,1]} \big) = {\mathrm{ind}}\big( \mathcal{T}(0),0,\mathcal{B}(0) \big) + {\mathrm{ind}}\big( \mathcal{T}(1),\mathcal{B}(1),0 \big) \\ &\quad= {\text{rel-ind}}\big( P_+(\mathcal{T}(0)+\mathcal{B}(0)) , P_+(\mathcal{T}(0)) \big) + {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(1)+\mathcal{B}(1)) \big) \\ &\quad= {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(0)) \big) , \end{align*} $$ $$ \begin{align*} &\text{sf}\big(\{\mathcal{T}(t)\}_{t\in[0,1]} \big) = {\mathrm{ind}}\big( \mathcal{T}(0),0,\mathcal{B}(0) \big) + {\mathrm{ind}}\big( \mathcal{T}(1),\mathcal{B}(1),0 \big) \\ &\quad= {\text{rel-ind}}\big( P_+(\mathcal{T}(0)+\mathcal{B}(0)) , P_+(\mathcal{T}(0)) \big) + {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(1)+\mathcal{B}(1)) \big) \\ &\quad= {\text{rel-ind}}\big( P_+(\mathcal{T}(1)) , P_+(\mathcal{T}(0)) \big) , \end{align*} $$ $\mathcal {B}(0) = 0$
 and $\mathcal {B}(0) = 0$
 and $\mathcal {T}(1)+\mathcal {B}(1) = \mathcal {T}(0)$
. $\mathcal {T}(1)+\mathcal {B}(1) = \mathcal {T}(0)$
.
We remark that for paths of operators on Hilbert spaces (rather than Hilbert modules), the identity (2.2) has been shown to hold even under more general continuity assumptions; see [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Theorem 3.6] and [Reference Wahl, Burghelea, Melrose, Mishchenko and TroitskyWah08, Proposition 2.5].
3 A generalised Callias-type theorem
3.1 Generalised Dirac-Schrödinger operators
Throughout this section, we will consider the following setting.
Assumption (A). Let A be a 
 $\sigma $
-unital
$\sigma $
-unital 
 $C^*$
-algebra, and let E be a countably generated Hilbert A-module. Let M be a connected Riemannian manifold (typically non-compact), and let
$C^*$
-algebra, and let E be a countably generated Hilbert A-module. Let M be a connected Riemannian manifold (typically non-compact), and let 
 $\mathcal {D}$
 be an essentially self-adjoint elliptic first-order differential operator on a hermitian vector bundle
$\mathcal {D}$
 be an essentially self-adjoint elliptic first-order differential operator on a hermitian vector bundle 
 ${\mathtt {F}}\to M$
. Let
${\mathtt {F}}\to M$
. Let 
 $\{\mathcal {S}(x)\}_{x\in M}$
 be a family of regular self-adjoint operators on E satisfying the following assumptions:
$\{\mathcal {S}(x)\}_{x\in M}$
 be a family of regular self-adjoint operators on E satisfying the following assumptions: 
- 
(A1) The domain  $W :=  {\mathrm {Dom}}\mathcal {S}(x)$
 is independent of $W :=  {\mathrm {Dom}}\mathcal {S}(x)$
 is independent of $x\in M$
, and the inclusion $x\in M$
, and the inclusion $W\hookrightarrow E$
 is compact (where W is viewed as a Hilbert A-module equipped with the graph norm of $W\hookrightarrow E$
 is compact (where W is viewed as a Hilbert A-module equipped with the graph norm of $\mathcal {S}(x_0)$
, for some $\mathcal {S}(x_0)$
, for some $x_0\in M$
). $x_0\in M$
).
- 
(A2) The map  $\mathcal {S}\colon M\to \mathcal {L}_A(W,E)$
 is norm-continuous. $\mathcal {S}\colon M\to \mathcal {L}_A(W,E)$
 is norm-continuous.
- 
(A3) There is a compact subset  $K\subset M$
 such that $K\subset M$
 such that $\mathcal {S}(x)$
 is uniformly invertible on $\mathcal {S}(x)$
 is uniformly invertible on $M\setminus K$
. $M\setminus K$
.
 Given the family of operators 
 $\{\mathcal {S}(x)\}_{x\in M}$
 on E, we obtain a closed symmetric operator
$\{\mathcal {S}(x)\}_{x\in M}$
 on E, we obtain a closed symmetric operator 
 $\mathcal {S}(\cdot )$
 on
$\mathcal {S}(\cdot )$
 on 
 $C_0(M,E)$
, which is defined as the closure of the operator
$C_0(M,E)$
, which is defined as the closure of the operator 
 $\big (\mathcal {S}(\cdot )\psi \big )(x) := \mathcal {S}(x) \psi (x)$
 on the initial dense domain
$\big (\mathcal {S}(\cdot )\psi \big )(x) := \mathcal {S}(x) \psi (x)$
 on the initial dense domain 
 $C_c(M,W)$
. By [Reference van den DungenDun19, Proposition 3.4], the operator
$C_c(M,W)$
. By [Reference van den DungenDun19, Proposition 3.4], the operator 
 $\mathcal {S}(\cdot )$
 on the Hilbert
$\mathcal {S}(\cdot )$
 on the Hilbert 
 $C_0(M,A)$
-module
$C_0(M,A)$
-module 
 $C_0(M,E)$
 is regular self-adjoint and Fredholm. Consequently, we obtain from [Reference van den DungenDun19, Proposition 2.14] a well-defined K-theory class
$C_0(M,E)$
 is regular self-adjoint and Fredholm. Consequently, we obtain from [Reference van den DungenDun19, Proposition 2.14] a well-defined K-theory class 

 Furthermore, since 
 $\mathcal {D}$
 is an essentially self-adjoint first-order differential operator, and since the ellipticity of
$\mathcal {D}$
 is an essentially self-adjoint first-order differential operator, and since the ellipticity of 
 $\mathcal {D}$
 ensures that
$\mathcal {D}$
 ensures that 
 $\mathcal {D}$
 also has locally compact resolvents [Reference Higson and RoeHR00, Proposition 10.5.2], we know that
$\mathcal {D}$
 also has locally compact resolvents [Reference Higson and RoeHR00, Proposition 10.5.2], we know that 
 $(C_0^1(M), L^2(M,{\mathtt {F}}), \mathcal {D})$
 is an (odd) spectral triple, which represents a K-homology class
$(C_0^1(M), L^2(M,{\mathtt {F}}), \mathcal {D})$
 is an (odd) spectral triple, which represents a K-homology class 

 We consider the balanced tensor product 
 $L^2(M,E\otimes {\mathtt {F}}) := C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
. The operator
$L^2(M,E\otimes {\mathtt {F}}) := C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
. The operator 
 $\mathcal {S}(\cdot )\otimes 1$
 is well-defined on
$\mathcal {S}(\cdot )\otimes 1$
 is well-defined on 
 $ {\mathrm {Dom}}\mathcal {S}(\cdot ) \otimes _{C_0(M)} L^2(M,{\mathtt {F}}) \subset L^2(M,E\otimes {\mathtt {F}})$
, and is denoted simply by
$ {\mathrm {Dom}}\mathcal {S}(\cdot ) \otimes _{C_0(M)} L^2(M,{\mathtt {F}}) \subset L^2(M,E\otimes {\mathtt {F}})$
, and is denoted simply by 
 $\mathcal {S}(\cdot )$
 as well. By [Reference LanceLan95, Proposition 9.10],
$\mathcal {S}(\cdot )$
 as well. By [Reference LanceLan95, Proposition 9.10], 
 $\mathcal {S}(\cdot )$
 is regular self-adjoint on
$\mathcal {S}(\cdot )$
 is regular self-adjoint on 
 $L^2(M,E\otimes {\mathtt {F}})$
.
$L^2(M,E\otimes {\mathtt {F}})$
.
 The operator 
 $1\otimes \mathcal {D}$
 is not well-defined on
$1\otimes \mathcal {D}$
 is not well-defined on 
 $L^2(M,E\otimes {\mathtt {F}})$
. Instead, using the canonical isomorphism
$L^2(M,E\otimes {\mathtt {F}})$
. Instead, using the canonical isomorphism 
 $L^2(M,E\otimes {\mathtt {F}}) \simeq E \otimes L^2(M,{\mathtt {F}})$
, we consider the operator
$L^2(M,E\otimes {\mathtt {F}}) \simeq E \otimes L^2(M,{\mathtt {F}})$
, we consider the operator 
 $1\otimes \mathcal {D}$
 on
$1\otimes \mathcal {D}$
 on 
 $E \otimes L^2(M,{\mathtt {F}})$
 with domain
$E \otimes L^2(M,{\mathtt {F}})$
 with domain 
 $E\otimes  {\mathrm {Dom}}\mathcal {D}$
. Alternatively, we can extend the exterior derivative on
$E\otimes  {\mathrm {Dom}}\mathcal {D}$
. Alternatively, we can extend the exterior derivative on 
 $C_0^1(M)$
 to an operator
$C_0^1(M)$
 to an operator 
 $$\begin{align*}d \colon C_0^1(M,E) \xrightarrow{\simeq} E\otimes C_0^1(M) \xrightarrow{1\otimes d} E\otimes\Gamma_0(T^*M) \xrightarrow{\simeq} \Gamma_0(E\otimes T^*M). \end{align*}$$
$$\begin{align*}d \colon C_0^1(M,E) \xrightarrow{\simeq} E\otimes C_0^1(M) \xrightarrow{1\otimes d} E\otimes\Gamma_0(T^*M) \xrightarrow{\simeq} \Gamma_0(E\otimes T^*M). \end{align*}$$
Denoting by 
 $\sigma $
 the principal symbol of
$\sigma $
 the principal symbol of 
 $\mathcal {D}$
, we can define an operator
$\mathcal {D}$
, we can define an operator 
 $1\otimes _d\mathcal {D}$
 on the Hilbert space
$1\otimes _d\mathcal {D}$
 on the Hilbert space 
 $C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
 by setting
$C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
 by setting 
 $$ \begin{align*}(1\otimes_d\mathcal{D})(\xi\otimes\psi) := \xi\otimes\mathcal{D}\psi + (1\otimes\sigma)(d\xi)\psi. \end{align*} $$
$$ \begin{align*}(1\otimes_d\mathcal{D})(\xi\otimes\psi) := \xi\otimes\mathcal{D}\psi + (1\otimes\sigma)(d\xi)\psi. \end{align*} $$
Under the isomorphism 
 $C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}}) \simeq E \otimes L^2(M,{\mathtt {F}})$
, the operator
$C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}}) \simeq E \otimes L^2(M,{\mathtt {F}})$
, the operator 
 $1\otimes \mathcal {D}$
 on
$1\otimes \mathcal {D}$
 on 
 $E \otimes L^2(M,{\mathtt {F}})$
 agrees with
$E \otimes L^2(M,{\mathtt {F}})$
 agrees with 
 $1\otimes _d\mathcal {D}$
 on
$1\otimes _d\mathcal {D}$
 on 
 $C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
. We will denote this operator on
$C_0(M,E) \otimes _{C_0(M)} L^2(M,{\mathtt {F}})$
. We will denote this operator on 
 $L^2(M,E\otimes {\mathtt {F}})$
 simply as
$L^2(M,E\otimes {\mathtt {F}})$
 simply as 
 $\mathcal {D}$
. The operator
$\mathcal {D}$
. The operator 
 $\mathcal {D}$
 is regular self-adjoint on
$\mathcal {D}$
 is regular self-adjoint on 
 $L^2(M,E\otimes {\mathtt {F}})$
 (see also [Reference Kaad and LeschKL13, Theorem 5.4]).
$L^2(M,E\otimes {\mathtt {F}})$
 (see also [Reference Kaad and LeschKL13, Theorem 5.4]).
Definition 3.1. Consider M, 
 $\mathcal {D}$
 and
$\mathcal {D}$
 and 
 $\mathcal {S}(\cdot )$
 satisfying assumption (A). We define the operator
$\mathcal {S}(\cdot )$
 satisfying assumption (A). We define the operator 
 $$\begin{align*}\mathcal{D}_{\mathcal{S}} := \mathcal{D} - i \mathcal{S}(\cdot) \end{align*}$$
$$\begin{align*}\mathcal{D}_{\mathcal{S}} := \mathcal{D} - i \mathcal{S}(\cdot) \end{align*}$$
on the initial domain 
 $C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}$
. Since
$C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}$
. Since 
 $\mathcal {D} + i \mathcal {S}(\cdot ) \subset \big ( \mathcal {D} - i \mathcal {S}(\cdot ) \big )^*$
 is densely defined (on the same domain),
$\mathcal {D} + i \mathcal {S}(\cdot ) \subset \big ( \mathcal {D} - i \mathcal {S}(\cdot ) \big )^*$
 is densely defined (on the same domain), 
 $\mathcal {D}-i\mathcal {S}(\cdot )$
 is closable, and (with slight abuse of notation) we denote its closure simply by
$\mathcal {D}-i\mathcal {S}(\cdot )$
 is closable, and (with slight abuse of notation) we denote its closure simply by 
 $\mathcal {D}_{\mathcal {S}}$
 as well.
$\mathcal {D}_{\mathcal {S}}$
 as well.
 The operator 
 $\mathcal {D}_{\mathcal {S}}$
 is called a generalised Dirac-Schrödinger operator if
$\mathcal {D}_{\mathcal {S}}$
 is called a generalised Dirac-Schrödinger operator if 
 $\mathcal {D}_{\mathcal {S}}$
 is regular and Fredholm, and
$\mathcal {D}_{\mathcal {S}}$
 is regular and Fredholm, and 
 $\mathcal {D}_{\mathcal {S}}^* = \mathcal {D}_{-\mathcal {S}}$
. In this case, we obtain a well-defined
$\mathcal {D}_{\mathcal {S}}^* = \mathcal {D}_{-\mathcal {S}}$
. In this case, we obtain a well-defined 
 $K_0(A)$
-valued index
$K_0(A)$
-valued index 
 $$\begin{align*}{\mathrm{Index}} \mathcal{D}_{\mathcal{S}} \in K_0(A). \end{align*}$$
$$\begin{align*}{\mathrm{Index}} \mathcal{D}_{\mathcal{S}} \in K_0(A). \end{align*}$$
For the definition of this index, we refer to [Reference van den DungenDun19, §2.2] and references therein.
 We note that, despite our use of the term ‘Dirac-Schrödinger’ operator, we do not assume that the operator 
 $\mathcal {D}$
 is of Dirac-type (although a Dirac-type operator is of course the typical example, as described in the Introduction). Furthermore, we note that regularity, the Fredholm property and the adjoint relation of
$\mathcal {D}$
 is of Dirac-type (although a Dirac-type operator is of course the typical example, as described in the Introduction). Furthermore, we note that regularity, the Fredholm property and the adjoint relation of 
 $\mathcal {D}_{\mathcal {S}}$
 do not follow automatically from assumption (A).
$\mathcal {D}_{\mathcal {S}}$
 do not follow automatically from assumption (A).
 In order to prove the Fredholm property of 
 $\mathcal {D}_{\mathcal {S}}$
, we consider in addition to assumption (A) also the following assumption:
$\mathcal {D}_{\mathcal {S}}$
, we consider in addition to assumption (A) also the following assumption:
Assumption (B). We assume the following conditions are satisfied:
- 
(B1) the map  $\mathcal {S} \colon M \to \mathcal {L}_A(W,E)$
 is weakly differentiable (i.e., for each $\mathcal {S} \colon M \to \mathcal {L}_A(W,E)$
 is weakly differentiable (i.e., for each $\psi \in W$
 and $\psi \in W$
 and $\eta \in E$
, the map $\eta \in E$
, the map $x \mapsto \langle \mathcal {S}(x)\psi |\eta \rangle $
 is differentiable), and the weak derivative $x \mapsto \langle \mathcal {S}(x)\psi |\eta \rangle $
 is differentiable), and the weak derivative $d\mathcal {S}(x) \colon W \to E\otimes T_x^*(M)$
 is bounded for all $d\mathcal {S}(x) \colon W \to E\otimes T_x^*(M)$
 is bounded for all $x\in M$
. $x\in M$
.
- 
(B2) the operator  $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\big )^{-1}$
 is well-defined and bounded (in the sense of [Reference Kaad and LeschKL12, Assumption 7.1] and [Reference van den DungenDun19, Definition 5.5]): there exists a core $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\big )^{-1}$
 is well-defined and bounded (in the sense of [Reference Kaad and LeschKL12, Assumption 7.1] and [Reference van den DungenDun19, Definition 5.5]): there exists a core $\mathcal {E}\subset  {\mathrm {Dom}}\mathcal {D}$
 for $\mathcal {E}\subset  {\mathrm {Dom}}\mathcal {D}$
 for $\mathcal {D}$
 such that for all $\mathcal {D}$
 such that for all $\xi \in \mathcal {E}$
 and for all $\xi \in \mathcal {E}$
 and for all $\mu \in (0,\infty )$
, we have the inclusions and the map $\mu \in (0,\infty )$
, we have the inclusions and the map $$\begin{align*}\big(\mathcal{S}(\cdot)\pm i\mu\big)^{-1} \xi \in {\mathrm{Dom}}\mathcal{S}(\cdot) \cap {\mathrm{Dom}}\mathcal{D} \quad \text{and} \quad \mathcal{D} \big(\mathcal{S}(\cdot)\pm i\mu\big)^{-1} \xi \in {\mathrm{Dom}}\mathcal{S}(\cdot) , \end{align*}$$ $$\begin{align*}\big(\mathcal{S}(\cdot)\pm i\mu\big)^{-1} \xi \in {\mathrm{Dom}}\mathcal{S}(\cdot) \cap {\mathrm{Dom}}\mathcal{D} \quad \text{and} \quad \mathcal{D} \big(\mathcal{S}(\cdot)\pm i\mu\big)^{-1} \xi \in {\mathrm{Dom}}\mathcal{S}(\cdot) , \end{align*}$$ $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\mu \big )^{-1} \colon \mathcal {E} \to L^2(M,E\otimes {\mathtt {F}})$
 extends to a bounded operator for all $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\mu \big )^{-1} \colon \mathcal {E} \to L^2(M,E\otimes {\mathtt {F}})$
 extends to a bounded operator for all $\mu \in (0,\infty )$
. $\mu \in (0,\infty )$
.
Remark 3.2.
- 
1. Assumption (B) requires the potential  $\mathcal {S}(\cdot )$
 to be differentiable (in a suitable sense). Alternatively, it is also possible to deal with continuous potentials, as is done in [Reference van den DungenDun19]. $\mathcal {S}(\cdot )$
 to be differentiable (in a suitable sense). Alternatively, it is also possible to deal with continuous potentials, as is done in [Reference van den DungenDun19].
- 
2. As described in [Reference Kaad and LeschKL13, Remark 8.4], assumption (B1) already implies assumption (A2). 
- 
3. If, in addition to (B1), we assume that  $\mathcal {D}$
 has bounded propagation speed, that $\mathcal {D}$
 has bounded propagation speed, that $ {\mathrm {Dom}}\mathcal {S}(\cdot ) \subset C_0(M,W)$
 (i.e., that there exists $ {\mathrm {Dom}}\mathcal {S}(\cdot ) \subset C_0(M,W)$
 (i.e., that there exists $C>0$
 such that for all $C>0$
 such that for all $x\in M$
, we have $x\in M$
, we have $\|\cdot \|_W \leq C \|\cdot \|_{\mathcal {S}(x)}$
), and that the weak derivative $\|\cdot \|_W \leq C \|\cdot \|_{\mathcal {S}(x)}$
), and that the weak derivative $d\mathcal {S}(\cdot )$
 is uniformly bounded, then the boundedness of $d\mathcal {S}(\cdot )$
 is uniformly bounded, then the boundedness of $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\big )^{-1}$
 in (B2) already follows. Indeed, as in [Reference Kaad and LeschKL13, Lemma 8.5 & Theorem 8.6], we can then write as a composition of bounded operators. $\big [\mathcal {D},\mathcal {S}(\cdot )\big ] \big (\mathcal {S}(\cdot )\pm i\big )^{-1}$
 in (B2) already follows. Indeed, as in [Reference Kaad and LeschKL13, Lemma 8.5 & Theorem 8.6], we can then write as a composition of bounded operators. $$ \begin{align*} \big[\mathcal{D},\mathcal{S}(\cdot)\big] &\big(\mathcal{S}(\cdot)\pm i\big)^{-1}= \sigma_{\mathcal{D}} \circ d\mathcal{S}(\cdot) \circ \big(\mathcal{S}(\cdot)\pm i\big)^{-1}\colon \\ &L^2(M,E\otimes{\mathtt{F}}) \xrightarrow{(\mathcal{S}(\cdot)\pm i)^{-1}} {\mathrm{Dom}}\mathcal{S}(\cdot) \otimes_{C_0(M)} L^2(M,{\mathtt{F}}) \hookrightarrow L^2(M,W\otimes{\mathtt{F}}) \\ &\qquad\qquad\qquad\qquad\qquad\qquad\qquad\xrightarrow{d\mathcal{S}(\cdot)} L^2(M,E\otimes T^*M\otimes{\mathtt{F}}) \xrightarrow{\sigma_{\mathcal{D}}} L^2(M,E\otimes{\mathtt{F}}) \end{align*} $$ $$ \begin{align*} \big[\mathcal{D},\mathcal{S}(\cdot)\big] &\big(\mathcal{S}(\cdot)\pm i\big)^{-1}= \sigma_{\mathcal{D}} \circ d\mathcal{S}(\cdot) \circ \big(\mathcal{S}(\cdot)\pm i\big)^{-1}\colon \\ &L^2(M,E\otimes{\mathtt{F}}) \xrightarrow{(\mathcal{S}(\cdot)\pm i)^{-1}} {\mathrm{Dom}}\mathcal{S}(\cdot) \otimes_{C_0(M)} L^2(M,{\mathtt{F}}) \hookrightarrow L^2(M,W\otimes{\mathtt{F}}) \\ &\qquad\qquad\qquad\qquad\qquad\qquad\qquad\xrightarrow{d\mathcal{S}(\cdot)} L^2(M,E\otimes T^*M\otimes{\mathtt{F}}) \xrightarrow{\sigma_{\mathcal{D}}} L^2(M,E\otimes{\mathtt{F}}) \end{align*} $$
Thanks to assumption (B), we have the following:
Proposition 3.3 [Reference Kaad and LeschKL12, Theorem 7.10].
 The operators 
 $\mathcal {D}_{\pm \mathcal {S}}$
 are regular on the domain
$\mathcal {D}_{\pm \mathcal {S}}$
 are regular on the domain 
 $ {\mathrm {Dom}}\mathcal {D}_{\mathcal {S}}$
 and satisfy
$ {\mathrm {Dom}}\mathcal {D}_{\mathcal {S}}$
 and satisfy 
 $\mathcal {D}_{\pm \mathcal {S}}^* = \mathcal {D}_{\mp \mathcal {S}}$
.
$\mathcal {D}_{\pm \mathcal {S}}^* = \mathcal {D}_{\mp \mathcal {S}}$
.
 The following theorem will be proven as the first statement of Theorem 4.4 below. It states that the operator 
 $\mathcal {D}_{\mathcal {S}}$
 is Fredholm, provided that (if necessary) the potential
$\mathcal {D}_{\mathcal {S}}$
 is Fredholm, provided that (if necessary) the potential 
 $\mathcal {S}(\cdot )$
 is rescaled by a sufficiently large
$\mathcal {S}(\cdot )$
 is rescaled by a sufficiently large 
 $\lambda>0$
.
$\lambda>0$
.
Theorem 3.4. There exists 
 $\lambda _0>0$
 such that for any
$\lambda _0>0$
 such that for any 
 $\lambda \geq \lambda _0$
, the operator
$\lambda \geq \lambda _0$
, the operator 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm and thus a generalised Dirac-Schrödinger operator.
$\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm and thus a generalised Dirac-Schrödinger operator.
 Our next theorem then describes the Fredholm index of a Dirac-Schrödinger operator in terms of the index pairing between the K-theory class of the potential 
 $\mathcal {S}(\cdot )$
 and the K-homology class of the elliptic operator
$\mathcal {S}(\cdot )$
 and the K-homology class of the elliptic operator 
 $\mathcal {D}$
. Results of this form were previously given by Bunke [Reference BunkeBun95] (see also [Reference KucerovskyKuc01]) in the classical case and in [Reference Kaad and LeschKL13, Reference van den DungenDun19] for ‘generalised’ Dirac-Schrödinger operators.
$\mathcal {D}$
. Results of this form were previously given by Bunke [Reference BunkeBun95] (see also [Reference KucerovskyKuc01]) in the classical case and in [Reference Kaad and LeschKL13, Reference van den DungenDun19] for ‘generalised’ Dirac-Schrödinger operators.
Theorem 3.5. Let M be a connected Riemannian manifold, and let 
 $\{\mathcal {S}(x)\}_{x\in M}$
 and
$\{\mathcal {S}(x)\}_{x\in M}$
 and 
 $\mathcal {D}$
 satisfy assumptions (A) and (B). Then there exists
$\mathcal {D}$
 satisfy assumptions (A) and (B). Then there exists 
 $\lambda _0>0$
 such that for any
$\lambda _0>0$
 such that for any 
 $\lambda \geq \lambda _0$
, the
$\lambda \geq \lambda _0$
, the 
 $K_0(A)$
-valued index of
$K_0(A)$
-valued index of 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 equals the pairing of
$\mathcal {D}_{\lambda \mathcal {S}}$
 equals the pairing of 
 $[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 with
$[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 with 
 $[\mathcal {D}] \in K^1(C_0(M))$
.
$[\mathcal {D}] \in K^1(C_0(M))$
.
 The proof is given in §4.3. It relies on identifying the classes as elements in Kasparov’s  -theory via the isomorphisms
-theory via the isomorphisms  ,
,  and
 and  , and then computing the index pairing using the description of the unbounded Kasparov product given in [Reference Kaad and LeschKL13].
, and then computing the index pairing using the description of the unbounded Kasparov product given in [Reference Kaad and LeschKL13].
3.2 Generalised Callias-type operators
 Let M, 
 $\mathcal {D}$
 and
$\mathcal {D}$
 and 
 $\mathcal {S}(\cdot )$
 satisfy assumptions (A) and (B) such that
$\mathcal {S}(\cdot )$
 satisfy assumptions (A) and (B) such that 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm (and hence a generalised Dirac-Schrödinger operator) for
$\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm (and hence a generalised Dirac-Schrödinger operator) for 
 $\lambda \geq \lambda _0> 0$
. In the remainder of this section, we furthermore assume the following:
$\lambda \geq \lambda _0> 0$
. In the remainder of this section, we furthermore assume the following:
Assumption (C). Without loss of generality, assume that the compact subset K from assumption (A3) has a smooth compact boundary N. We assume furthermore that the following conditions are satisfied:
- 
(C1) The operator  $\mathcal {D}$
 is of ‘product form’ near N in the following sense. There exists a collar neighbourhood $\mathcal {D}$
 is of ‘product form’ near N in the following sense. There exists a collar neighbourhood $C \simeq (-2\varepsilon ,2\varepsilon ) \times N$
 of N (with $C \simeq (-2\varepsilon ,2\varepsilon ) \times N$
 of N (with $(-2\varepsilon ,0) \times N$
 in the interior of K), where we can identify $(-2\varepsilon ,0) \times N$
 in the interior of K), where we can identify ${\mathtt {F}}|_C$
 with the pullback of ${\mathtt {F}}|_C$
 with the pullback of ${\mathtt {F}}_N := {\mathtt {F}}|_N \to N$
 to ${\mathtt {F}}_N := {\mathtt {F}}|_N \to N$
 to $C \simeq (-2\varepsilon ,2\varepsilon ) \times N$
, so that $C \simeq (-2\varepsilon ,2\varepsilon ) \times N$
, so that $\Gamma ^\infty ({\mathtt {F}}|_C) \simeq C^\infty \big ( (-2\varepsilon ,2\varepsilon ) \big ) \otimes \Gamma ^\infty ({\mathtt {F}}_N)$
. On this collar neighbourhood, we have $\Gamma ^\infty ({\mathtt {F}}|_C) \simeq C^\infty \big ( (-2\varepsilon ,2\varepsilon ) \big ) \otimes \Gamma ^\infty ({\mathtt {F}}_N)$
. On this collar neighbourhood, we have $\mathcal {D}|_C \simeq -i\partial _r \otimes \Gamma _N + 1 \otimes \mathcal {D}_N$
, where $\mathcal {D}|_C \simeq -i\partial _r \otimes \Gamma _N + 1 \otimes \mathcal {D}_N$
, where $\mathcal {D}_N$
 is an essentially self-adjoint elliptic first-order differential operator on $\mathcal {D}_N$
 is an essentially self-adjoint elliptic first-order differential operator on ${\mathtt {F}}_N\to N$
, and where ${\mathtt {F}}_N\to N$
, and where $\Gamma _N \in \Gamma ^\infty ( {\mathrm {End}}{\mathtt {F}}_N)$
 is a self-adjoint unitary satisfying $\Gamma _N \in \Gamma ^\infty ( {\mathrm {End}}{\mathtt {F}}_N)$
 is a self-adjoint unitary satisfying $\Gamma _N \mathcal {D}_N = - \mathcal {D}_N \Gamma _N$
. $\Gamma _N \mathcal {D}_N = - \mathcal {D}_N \Gamma _N$
.
- 
(C2) For any  $x,y\in K$
, $x,y\in K$
, $\mathcal {S}(x)-\mathcal {S}(y)$
 is relatively $\mathcal {S}(x)-\mathcal {S}(y)$
 is relatively $\mathcal {S}(x)$
-compact. $\mathcal {S}(x)$
-compact.
Moreover, we fix an (arbitrary) invertible regular self-adjoint operator 
 $\mathcal {T}$
 on E with domain
$\mathcal {T}$
 on E with domain 
 $ {\mathrm {Dom}}\mathcal {T} = W$
, such that
$ {\mathrm {Dom}}\mathcal {T} = W$
, such that 
 $\mathcal {S}(x)-\mathcal {T}$
 is relatively
$\mathcal {S}(x)-\mathcal {T}$
 is relatively 
 $\mathcal {T}$
-compact for some (and hence, by (C2), for every)
$\mathcal {T}$
-compact for some (and hence, by (C2), for every) 
 $x\in K$
.
$x\in K$
.
Remark 3.6.
- 
1. For the definition and properties of relatively compact operators, we refer the reader to §A.3 in the Appendix. 
- 
2. The product form of  $\mathcal {D}$
 in assumption (C1) is typical of Dirac operators corresponding to a product metric on the collar neighbourhood C of N, where $\mathcal {D}$
 in assumption (C1) is typical of Dirac operators corresponding to a product metric on the collar neighbourhood C of N, where $\Gamma _N$
 is given by Clifford multiplication with the unit normal vector $\Gamma _N$
 is given by Clifford multiplication with the unit normal vector $\partial _r$
 to N (actually, one might often write $\partial _r$
 to N (actually, one might often write $\mathcal {D}_C' = -i (1\otimes \Gamma _N) (\partial _r \otimes 1 + 1 \otimes \mathcal {D}_N)$
, but these two product forms are in fact unitarily equivalent). However, in this paper, we do not insist that $\mathcal {D}_C' = -i (1\otimes \Gamma _N) (\partial _r \otimes 1 + 1 \otimes \mathcal {D}_N)$
, but these two product forms are in fact unitarily equivalent). However, in this paper, we do not insist that $\mathcal {D}$
 is of Dirac-type. One can view assumption (C1) as requiring precisely those properties of Dirac operators which we need below (in particular, to prove Lemma 4.3). $\mathcal {D}$
 is of Dirac-type. One can view assumption (C1) as requiring precisely those properties of Dirac operators which we need below (in particular, to prove Lemma 4.3).
- 
3. We remind the reader that assumption (C2) is motivated by the spectral flow result from Proposition 2.8. 
- 
4. We note that, for the operator  $\mathcal {T}$
, we can for instance choose $\mathcal {T}$
, we can for instance choose $\mathcal {T} = \mathcal {S}(x_0)$
 for some $\mathcal {T} = \mathcal {S}(x_0)$
 for some $x_0\in K$
, but it can be useful to allow for arbitrary relatively compact perturbations. $x_0\in K$
, but it can be useful to allow for arbitrary relatively compact perturbations.
Definition 3.7. If assumptions (A), (B) and (C) are satisfied, then the generalised Dirac-Schrödinger operator 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 is called a generalised Callias-type operator.
$\mathcal {D}_{\lambda \mathcal {S}}$
 is called a generalised Callias-type operator.
 (We always implicitly assume that 
 $\lambda \geq \lambda _0>0$
 such that
$\lambda \geq \lambda _0>0$
 such that 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm.)
$\mathcal {D}_{\lambda \mathcal {S}}$
 is Fredholm.)
 We consider the invertible regular self-adjoint operator 
 $\mathcal {T}(\cdot )$
 on
$\mathcal {T}(\cdot )$
 on 
 $C(N,E)$
 corresponding to the constant family
$C(N,E)$
 corresponding to the constant family 
 $\mathcal {T}(y) := \mathcal {T}$
 (for
$\mathcal {T}(y) := \mathcal {T}$
 (for 
 $y\in N$
). The restriction of the potential
$y\in N$
). The restriction of the potential 
 $\mathcal {S}(\cdot )$
 to the hypersurface N also yields an invertible regular self-adjoint operator
$\mathcal {S}(\cdot )$
 to the hypersurface N also yields an invertible regular self-adjoint operator 
 $\mathcal {S}_N(\cdot ) = \{\mathcal {S}(y)\}_{y\in N}$
 on
$\mathcal {S}_N(\cdot ) = \{\mathcal {S}(y)\}_{y\in N}$
 on 
 $C(N,E)$
. We recall that
$C(N,E)$
. We recall that 
 $\mathcal {S}(y) - \mathcal {T}$
 is relatively
$\mathcal {S}(y) - \mathcal {T}$
 is relatively 
 $\mathcal {T}$
-compact for each
$\mathcal {T}$
-compact for each 
 $y\in N$
. Furthermore,
$y\in N$
. Furthermore, 
 $\mathcal {S}(y) \big ( \mathcal {T}\pm i \big )^{-1}$
 depends norm-continuously on y by assumption (A2). Hence,
$\mathcal {S}(y) \big ( \mathcal {T}\pm i \big )^{-1}$
 depends norm-continuously on y by assumption (A2). Hence, 
 $\mathcal {S}_N(\cdot ) - \mathcal {T}(\cdot )$
 is relatively
$\mathcal {S}_N(\cdot ) - \mathcal {T}(\cdot )$
 is relatively 
 $\mathcal {T}(\cdot )$
-compact. We then know from Corollary A.10 that the difference of positive spectral projections
$\mathcal {T}(\cdot )$
-compact. We then know from Corollary A.10 that the difference of positive spectral projections 
 $P_+(\mathcal {S}_N(\cdot )) - P_+(\mathcal {T}(\cdot ))$
 is compact, so that the relative index
$P_+(\mathcal {S}_N(\cdot )) - P_+(\mathcal {T}(\cdot ))$
 is compact, so that the relative index 
 $ {\mathrm {rel-ind}}\big (P_+(\mathcal {S}_N(\cdot )),P_+(\mathcal {T}(\cdot ))\big )$
 is well-defined in
$ {\mathrm {rel-ind}}\big (P_+(\mathcal {S}_N(\cdot )),P_+(\mathcal {T}(\cdot ))\big )$
 is well-defined in 
 $K_1(C(N,A))$
 (see Definition 2.2). We are now ready to state our generalisation of the Callias Theorem.
$K_1(C(N,A))$
 (see Definition 2.2). We are now ready to state our generalisation of the Callias Theorem.
Theorem 3.8 (Generalised Callias Theorem).
 Let 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Then we have the equality
$\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Then we have the equality 
 $$ \begin{align*} {\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A) , \end{align*} $$
$$ \begin{align*} {\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A) , \end{align*} $$
where 
 $\otimes _{C(N)}$
 denotes the pairing
$\otimes _{C(N)}$
 denotes the pairing 
 $K_1(C(N,A)) \times K^1(C(N)) \to K_0(A)$
.
$K_1(C(N,A)) \times K^1(C(N)) \to K_0(A)$
.
Remark 3.9. Although the relative index depends explicitly on the choice of 
 $\mathcal {T}$
, the theorem in particular shows that the pairing
$\mathcal {T}$
, the theorem in particular shows that the pairing 
 $ {\mathrm {rel-ind}}\big (P_+(\mathcal {S}_N(\cdot )),P_+(\mathcal {T}(\cdot ))\big ) \otimes _{C(N)} [\mathcal {D}_N]$
 on the right-hand side is in fact independent of this choice. This independence of
$ {\mathrm {rel-ind}}\big (P_+(\mathcal {S}_N(\cdot )),P_+(\mathcal {T}(\cdot ))\big ) \otimes _{C(N)} [\mathcal {D}_N]$
 on the right-hand side is in fact independent of this choice. This independence of 
 $\mathcal {T}$
 can be understood as a consequence of the cobordism invariance of the index (since N is the boundary of K, the index of
$\mathcal {T}$
 can be understood as a consequence of the cobordism invariance of the index (since N is the boundary of K, the index of 
 $\mathcal {D}_N$
 vanishes). In fact, one can also turn this around and prove the cobordism invariance of the index as a consequence of the Callias Theorem (by considering the trivial rank-one bundle
$\mathcal {D}_N$
 vanishes). In fact, one can also turn this around and prove the cobordism invariance of the index as a consequence of the Callias Theorem (by considering the trivial rank-one bundle 
 $M\times \mathbb {C}$
 with the potential
$M\times \mathbb {C}$
 with the potential 
 $\mathcal {S}(\cdot )=1$
, and the operator
$\mathcal {S}(\cdot )=1$
, and the operator 
 $\mathcal {T}=-1$
 on
$\mathcal {T}=-1$
 on 
 $E=A=\mathbb {C}$
).
$E=A=\mathbb {C}$
).
 We observe next that our assumption (C2) ensures that the class 
 $[\mathcal {S}(\cdot )]$
 of the potential depends only on the hypersurface N. This is the crucial observation which enables one to obtain the index of the Callias-type operator from a computation on the hypersurface N, as in Equation (1.1) in the Introduction. Consider the open subset
$[\mathcal {S}(\cdot )]$
 of the potential depends only on the hypersurface N. This is the crucial observation which enables one to obtain the index of the Callias-type operator from a computation on the hypersurface N, as in Equation (1.1) in the Introduction. Consider the open subset 
 $U := K\cup C \subset M$
 with compact closure
$U := K\cup C \subset M$
 with compact closure 
 $\overline U$
 and boundary
$\overline U$
 and boundary 
 $\partial U\simeq N$
. We have the short exact sequence
$\partial U\simeq N$
. We have the short exact sequence 
 $$ \begin{align} 0 &\rightarrow C_0(U,A) \xrightarrow{j} C(\overline U,A) \to C(N,A) \to 0 \end{align} $$
$$ \begin{align} 0 &\rightarrow C_0(U,A) \xrightarrow{j} C(\overline U,A) \to C(N,A) \to 0 \end{align} $$
and the corresponding cyclic six-term exact sequences in K-theory and K-homology.
Proposition 3.10. The K-theory class 
 $[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 is uniquely determined by an element
$[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 is uniquely determined by an element 
 $\Sigma _N \in K_0(C(N,A))$
. More explicitly, we have
$\Sigma _N \in K_0(C(N,A))$
. More explicitly, we have 
 $$\begin{align*}[\mathcal{S}(\cdot)] = {\iota_U}_* \circ \partial(\Sigma_N) , \end{align*}$$
$$\begin{align*}[\mathcal{S}(\cdot)] = {\iota_U}_* \circ \partial(\Sigma_N) , \end{align*}$$
where 
 $\partial \colon K_0(C(N,A)) \to K_1(C_0(U,A))$
 denotes the exponential map in the cyclic six-term exact sequence in K-theory corresponding to the short exact sequence (3.1), and where
$\partial \colon K_0(C(N,A)) \to K_1(C_0(U,A))$
 denotes the exponential map in the cyclic six-term exact sequence in K-theory corresponding to the short exact sequence (3.1), and where 
 ${\iota _U}_* \colon K_1(C_0(U,A)) \to K_1(C_0(M,A))$
 is induced by the inclusion
${\iota _U}_* \colon K_1(C_0(U,A)) \to K_1(C_0(M,A))$
 is induced by the inclusion 
 $\iota _U \colon C_0(U,A) \hookrightarrow C_0(M,A)$
.
$\iota _U \colon C_0(U,A) \hookrightarrow C_0(M,A)$
.
Proof. The invertibility of the potential 
 $\mathcal {S}(\cdot )$
 outside of the compact subset K ensures that the class
$\mathcal {S}(\cdot )$
 outside of the compact subset K ensures that the class 
 $[\mathcal {S}(\cdot )]$
 depends only on the restriction of
$[\mathcal {S}(\cdot )]$
 depends only on the restriction of 
 $\mathcal {S}(\cdot )$
 to U. Indeed, we have from [Reference van den DungenDun19, Lemma 3.8] the equality
$\mathcal {S}(\cdot )$
 to U. Indeed, we have from [Reference van den DungenDun19, Lemma 3.8] the equality 
 $[\mathcal {S}(\cdot )] = {\iota _U}_*\big ([\mathcal {S}(\cdot )|_U]\big )$
.
$[\mathcal {S}(\cdot )] = {\iota _U}_*\big ([\mathcal {S}(\cdot )|_U]\big )$
.
 We may assume, without loss of generality, that assumption (C2) holds for all 
 $x\in \overline U$
 (see Lemma 5.1 below for an explicit computation). Using compactness of
$x\in \overline U$
 (see Lemma 5.1 below for an explicit computation). Using compactness of 
 $\overline U$
, it follows that the operator
$\overline U$
, it follows that the operator 
 $\mathcal {S}(\cdot )|_{\overline U}$
 is a relatively compact perturbation of the invertible operator
$\mathcal {S}(\cdot )|_{\overline U}$
 is a relatively compact perturbation of the invertible operator 
 $\mathcal {T}(\cdot )_{\overline U} = \{\mathcal {T}\}_{x\in \overline U}$
, and therefore,
$\mathcal {T}(\cdot )_{\overline U} = \{\mathcal {T}\}_{x\in \overline U}$
, and therefore, 
 $j_*\big (\big [\mathcal {S}(\cdot )|_{U}\big ]\big ) = 0 \in K_1(C(\overline U,A))$
. From the cyclic six-term exact sequence in K-theory, we conclude that
$j_*\big (\big [\mathcal {S}(\cdot )|_{U}\big ]\big ) = 0 \in K_1(C(\overline U,A))$
. From the cyclic six-term exact sequence in K-theory, we conclude that 
 $\big [\mathcal {S}(\cdot )|_{U}\big ]$
 lies in the image of the exponential map
$\big [\mathcal {S}(\cdot )|_{U}\big ]$
 lies in the image of the exponential map 
 $\partial \colon K_0(C(N,A)) \to K_1(C_0(U,A))$
, so there exists a class
$\partial \colon K_0(C(N,A)) \to K_1(C_0(U,A))$
, so there exists a class 
 $\Sigma _N \in K_0(C(N,A))$
 such that
$\Sigma _N \in K_0(C(N,A))$
 such that 
 $\partial (\Sigma _N) = [\mathcal {S}(\cdot )|_U]$
.
$\partial (\Sigma _N) = [\mathcal {S}(\cdot )|_U]$
.
The above proposition ensures that we can apply Equation (1.1), and combined with Theorem 3.5, we obtain the equality
 $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = \Sigma_N \otimes_{C(N)} [\mathcal{D}_N]. \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = \Sigma_N \otimes_{C(N)} [\mathcal{D}_N]. \end{align*}$$
Thus, in order to prove Theorem 3.8, it remains to explicitly identify the K-theory class 
 $\Sigma _N \in K_0(C(N,A))$
 as the relative index of the positive spectral projections
$\Sigma _N \in K_0(C(N,A))$
 as the relative index of the positive spectral projections 
 $P_+(\mathcal {S}_N(\cdot ))$
 and
$P_+(\mathcal {S}_N(\cdot ))$
 and 
 $P_+(\mathcal {T}(\cdot ))$
. We will obtain this identification in Section 5 by first reducing the general statement to the special case of a cylindrical manifold
$P_+(\mathcal {T}(\cdot ))$
. We will obtain this identification in Section 5 by first reducing the general statement to the special case of a cylindrical manifold 
 $\mathbb {R}\times N$
 (see Theorem 5.4). The main advantage of considering the cylindrical manifold is, roughly speaking, that we can then invert the boundary map in order to explicitly compute a solution
$\mathbb {R}\times N$
 (see Theorem 5.4). The main advantage of considering the cylindrical manifold is, roughly speaking, that we can then invert the boundary map in order to explicitly compute a solution 
 $\Sigma _N$
 of the equation
$\Sigma _N$
 of the equation 
 $[\mathcal {S}(\cdot )|_U] = \partial (\Sigma _N)$
.
$[\mathcal {S}(\cdot )|_U] = \partial (\Sigma _N)$
.
3.3 Special cases
In this subsection, we reconsider the two well-known special cases of our generalised Callias Theorem, described in Section 2.
 First, in the special case when E is a finite-dimensional Hilbert space, we recover the classical Callias Theorem 2.1 (though only for globally trivial bundles). In fact, we find that the statement of the classical Callias Theorem continues to hold if E is a finitely generated projective module over a unital 
 $C^*$
-algebra A.
$C^*$
-algebra A.
Corollary 3.11. Let 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Suppose furthermore that A is unital and that E is finitely generated and projective over A. Then
$\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Suppose furthermore that A is unital and that E is finitely generated and projective over A. Then 
 $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big] \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A). \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\lambda\mathcal{S}} \big) = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big] \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A). \end{align*}$$
Proof. The assumptions on A and E ensure that all operators on E are compact. In particular, the operator 
 $\mathcal {T}:=-1$
 is a relatively compact perturbation of each
$\mathcal {T}:=-1$
 is a relatively compact perturbation of each 
 $\mathcal {S}_N(y)$
. With
$\mathcal {S}_N(y)$
. With 
 $P_+(\mathcal {T}(\cdot )) = 0$
, we therefore obtain
$P_+(\mathcal {T}(\cdot )) = 0$
, we therefore obtain 
 $$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),0\big) = {\mathrm{Index}}\big( 0 \colon {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \to \{0\} \big) = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big]. \end{align*}$$
$$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),0\big) = {\mathrm{Index}}\big( 0 \colon {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \to \{0\} \big) = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big]. \end{align*}$$
Thus, from Theorem 3.8, we find that
 $$ \begin{align*} {\mathrm{Index}} \big(\mathcal{D}_{\lambda\mathcal{S}} \big) &= {\text{rel-ind}} \big(P_+(\mathcal{S}_N(\cdot)),0\big) \otimes_{C(N)} [\mathcal{D}_N] = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big] \otimes_{C(N)} [\mathcal{D}_N].\\[-41pt] \end{align*} $$
$$ \begin{align*} {\mathrm{Index}} \big(\mathcal{D}_{\lambda\mathcal{S}} \big) &= {\text{rel-ind}} \big(P_+(\mathcal{S}_N(\cdot)),0\big) \otimes_{C(N)} [\mathcal{D}_N] = \big[ {\mathrm{Ran}} P_+(\mathcal{S}_N(\cdot)) \big] \otimes_{C(N)} [\mathcal{D}_N].\\[-41pt] \end{align*} $$
 Second, in the special case where 
 $M=\mathbb {R}$
, we recover the equality between the spectral flow and the relative index of spectral projections of the end-points from Proposition 2.8.
$M=\mathbb {R}$
, we recover the equality between the spectral flow and the relative index of spectral projections of the end-points from Proposition 2.8.
Corollary 3.12. Consider the operator 
 $\mathcal {D} = -i\partial _t$
 on the manifold
$\mathcal {D} = -i\partial _t$
 on the manifold 
 $M=\mathbb {R}$
 and a potential
$M=\mathbb {R}$
 and a potential 
 $\mathcal {S}(\cdot ) = \big \{ \mathcal {S}(t) \big \}_{t\in \mathbb {R}}$
 satisfying assumptions (A), (B) and (C). Suppose for simplicity that the compact subset from assumption (A3) is given by the unit interval
$\mathcal {S}(\cdot ) = \big \{ \mathcal {S}(t) \big \}_{t\in \mathbb {R}}$
 satisfying assumptions (A), (B) and (C). Suppose for simplicity that the compact subset from assumption (A3) is given by the unit interval 
 $K = [0,1]$
. Then we have the equality
$K = [0,1]$
. Then we have the equality 
 $$ \begin{align*} \text{sf}\big(\{\mathcal{S}(t)\}_{t\in[0,1]}\big) &= {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big). \end{align*} $$
$$ \begin{align*} \text{sf}\big(\{\mathcal{S}(t)\}_{t\in[0,1]}\big) &= {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big). \end{align*} $$
Proof. From Theorem 3.8, we obtain
 $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big) = {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] , \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big) = {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] , \end{align*}$$
where the ‘hypersurface’ 
 $N = \{0,1\}$
 consists of the endpoints of the unit interval, and
$N = \{0,1\}$
 consists of the endpoints of the unit interval, and 
 $\mathcal {T}$
 is any relatively compact perturbation of
$\mathcal {T}$
 is any relatively compact perturbation of 
 $\mathcal {S}(0)$
. We will examine both the left-hand side and the right-hand side of the above equation.
$\mathcal {S}(0)$
. We will examine both the left-hand side and the right-hand side of the above equation.
First, the left-hand side is given by
 $$\begin{align*}{\mathrm{Index}}\big( {-i\partial_t} - i \lambda \mathcal{S}(\cdot) \big) = [\mathcal{S}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_t] = \text{sf}\big(\{\mathcal{S}(t)\}_{t\in[0,1]}\big) , \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( {-i\partial_t} - i \lambda \mathcal{S}(\cdot) \big) = [\mathcal{S}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_t] = \text{sf}\big(\{\mathcal{S}(t)\}_{t\in[0,1]}\big) , \end{align*}$$
where the first equality is obtained from Theorem 3.5, and the second from [Reference van den DungenDun19, Proposition 2.21] (using that trivialising families exist by Proposition 2.8.(1)).
 For the right-hand side, we examine the product form of 
 $-i\partial _t$
 near
$-i\partial _t$
 near 
 $N=\{0,1\}$
. The operator
$N=\{0,1\}$
. The operator 
 $\mathcal {D}_N$
 is just the zero operator on
$\mathcal {D}_N$
 is just the zero operator on 
 ${\mathtt {F}}_N = {\mathtt {F}}_{\{0\}} \oplus {\mathtt {F}}_{\{1\}} \simeq \mathbb {C}\oplus \mathbb {C}$
. We note that the coordinate r increases in the outward direction, so we have
${\mathtt {F}}_N = {\mathtt {F}}_{\{0\}} \oplus {\mathtt {F}}_{\{1\}} \simeq \mathbb {C}\oplus \mathbb {C}$
. We note that the coordinate r increases in the outward direction, so we have 
 $t=-r$
 near
$t=-r$
 near 
 $0$
 and
$0$
 and 
 $t=1+r$
 near
$t=1+r$
 near 
 $1$
. Thus, on a collar neighbourhood of N, we can write
$1$
. Thus, on a collar neighbourhood of N, we can write 
 $-i\partial _t \simeq i\partial _r \oplus (-i\partial _r) = -i\partial _r \otimes \Gamma _N$
, where the operator
$-i\partial _t \simeq i\partial _r \oplus (-i\partial _r) = -i\partial _r \otimes \Gamma _N$
, where the operator 
 $\Gamma _N$
 is given by
$\Gamma _N$
 is given by 
 $(-1) \oplus 1$
 on
$(-1) \oplus 1$
 on 
 ${\mathtt {F}}_{\{0\}} \oplus {\mathtt {F}}_{\{1\}}$
. Thus,
${\mathtt {F}}_{\{0\}} \oplus {\mathtt {F}}_{\{1\}}$
. Thus, 
 ${\mathtt {F}}_{\{0\}} = {\mathtt {F}}^-_{\{0\}} = \mathbb {C}$
 and
${\mathtt {F}}_{\{0\}} = {\mathtt {F}}^-_{\{0\}} = \mathbb {C}$
 and 
 ${\mathtt {F}}_{\{1\}} = {\mathtt {F}}^+_{\{1\}} = \mathbb {C}$
, and we can identify
${\mathtt {F}}_{\{1\}} = {\mathtt {F}}^+_{\{1\}} = \mathbb {C}$
, and we can identify  with
 with 
 $(-1)\oplus 1 \in \mathbb {Z}\oplus \mathbb {Z}$
. Then the Kasparov product over
$(-1)\oplus 1 \in \mathbb {Z}\oplus \mathbb {Z}$
. Then the Kasparov product over 
 $C(N)=\mathbb {C}^2$
 can be calculated as follows:
$C(N)=\mathbb {C}^2$
 can be calculated as follows: 
 $$ \begin{align*} {\text{rel-ind}}&\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{\mathbb{C}^2} [\mathcal{D}_N] \\ &= {\text{rel-ind}}\big(P_+(\mathcal{S}(0)),P_+(\mathcal{T})\big) \otimes (-1) + {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{T})\big) \otimes 1 \\ &= {\text{rel-ind}}\big(P_+(\mathcal{T}),P_+(\mathcal{S}(0))\big) + {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{T})\big) \\ &= {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big).\\[-41pt] \end{align*} $$
$$ \begin{align*} {\text{rel-ind}}&\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{\mathbb{C}^2} [\mathcal{D}_N] \\ &= {\text{rel-ind}}\big(P_+(\mathcal{S}(0)),P_+(\mathcal{T})\big) \otimes (-1) + {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{T})\big) \otimes 1 \\ &= {\text{rel-ind}}\big(P_+(\mathcal{T}),P_+(\mathcal{S}(0))\big) + {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{T})\big) \\ &= {\text{rel-ind}}\big(P_+(\mathcal{S}(1)),P_+(\mathcal{S}(0))\big).\\[-41pt] \end{align*} $$
4 Generalised Dirac-Schrödinger operators
 Consider M, 
 $\mathcal {D}$
 and
$\mathcal {D}$
 and 
 $\mathcal {S}(\cdot )$
 satisfying assumption (A). We have defined in Definition 3.1 the operator
$\mathcal {S}(\cdot )$
 satisfying assumption (A). We have defined in Definition 3.1 the operator 
 $\mathcal{D}_{\mathcal{S}} := \mathcal{D} - i\mathcal{S}(\cdot)$
 on the initial domain
$\mathcal{D}_{\mathcal{S}} := \mathcal{D} - i\mathcal{S}(\cdot)$
 on the initial domain 
 $C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}$
. We now also define the operators
$C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}$
. We now also define the operators 
 $$ \begin{gather*} \widetilde{\mathcal{D}} := \begin{pmatrix}0&\mathcal{D}\\ \mathcal{D}&0\end{pmatrix} , \qquad \widetilde{\mathcal{S}}(\cdot) := \begin{pmatrix}0&+i\mathcal{S}(\cdot)\\ -i\mathcal{S}(\cdot)&0\end{pmatrix} , \\ \widetilde{\mathcal{D}}_{\mathcal{S}} := \widetilde{\mathcal{D}} + \widetilde{\mathcal{S}}(\cdot) = \begin{pmatrix}0&\mathcal{D}+i\mathcal{S}(\cdot)\\ \mathcal{D}-i\mathcal{S}(\cdot)&0\end{pmatrix} , \end{gather*} $$
$$ \begin{gather*} \widetilde{\mathcal{D}} := \begin{pmatrix}0&\mathcal{D}\\ \mathcal{D}&0\end{pmatrix} , \qquad \widetilde{\mathcal{S}}(\cdot) := \begin{pmatrix}0&+i\mathcal{S}(\cdot)\\ -i\mathcal{S}(\cdot)&0\end{pmatrix} , \\ \widetilde{\mathcal{D}}_{\mathcal{S}} := \widetilde{\mathcal{D}} + \widetilde{\mathcal{S}}(\cdot) = \begin{pmatrix}0&\mathcal{D}+i\mathcal{S}(\cdot)\\ \mathcal{D}-i\mathcal{S}(\cdot)&0\end{pmatrix} , \end{gather*} $$
on the initial domain 
 $\big (C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}\big )^{\oplus 2}$
. The operator
$\big (C_c^1(M,W) \otimes _{C_0^1(M)}  {\mathrm {Dom}}\mathcal {D}\big )^{\oplus 2}$
. The operator 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}$
 is odd with respect to the
$\widetilde {\mathcal {D}}_{\mathcal {S}}$
 is odd with respect to the 
 $\mathbb {Z}_2$
-grading
$\mathbb {Z}_2$
-grading 
 $\Gamma := \begin {pmatrix}1&0\\ 0&-1\end {pmatrix}$
.
$\Gamma := \begin {pmatrix}1&0\\ 0&-1\end {pmatrix}$
.
 We recall that 
 $\mathcal {D}_{\mathcal {S}}$
 is called a generalised Dirac-Schrödinger operator if
$\mathcal {D}_{\mathcal {S}}$
 is called a generalised Dirac-Schrödinger operator if 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}$
 is regular, self-adjoint and Fredholm. In this case, the operator
$\widetilde {\mathcal {D}}_{\mathcal {S}}$
 is regular, self-adjoint and Fredholm. In this case, the operator 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}$
 yields a class
$\widetilde {\mathcal {D}}_{\mathcal {S}}$
 yields a class 

corresponding to the 
 $K_0(A)$
-valued index of
$K_0(A)$
-valued index of 
 $\mathcal {D}_{\mathcal {S}}$
 under the isomorphism
$\mathcal {D}_{\mathcal {S}}$
 under the isomorphism  . For the construction of this class in Kasparov’s
. For the construction of this class in Kasparov’s  -theory and its relation to the Fredholm index, we refer to [Reference van den DungenDun19, §2.2].
-theory and its relation to the Fredholm index, we refer to [Reference van den DungenDun19, §2.2].
4.1 Relative index theorem
An important tool for our index computations is the relative index theorem [Reference van den DungenDun19, Theorem 4.7], which is an adaptation of a theorem by Bunke [Reference BunkeBun95, Theorem 1.14]. Here, we shall adapt [Reference van den DungenDun19, Theorem 4.7] in order to allow for more general situations (in particular, we avoid the assumption (A4) from [Reference van den DungenDun19, §3.2]).
 We consider the following setting. For 
 $j=1,2$
, let
$j=1,2$
, let 
 ${\mathtt {F}}^j\to M^j$
,
${\mathtt {F}}^j\to M^j$
, 
 $\mathcal {D}^j$
 and
$\mathcal {D}^j$
 and 
 $\mathcal {S}^j(\cdot )$
 be as in assumption (A), and assume that the operators
$\mathcal {S}^j(\cdot )$
 be as in assumption (A), and assume that the operators 
 $\{\mathcal {S}^j(x)\}_{x\in M^j}$
 act on the same Hilbert A-module E. Suppose we have partitions
$\{\mathcal {S}^j(x)\}_{x\in M^j}$
 act on the same Hilbert A-module E. Suppose we have partitions 
 $M^j = \overline U^j \cup _{N^j} \overline V^j$
, where
$M^j = \overline U^j \cup _{N^j} \overline V^j$
, where 
 $N^j$
 are smooth compact hypersurfaces. Let
$N^j$
 are smooth compact hypersurfaces. Let 
 $C^j$
 be open tubular neighbourhoods of
$C^j$
 be open tubular neighbourhoods of 
 $N^j$
, and assume that there exists an isometry
$N^j$
, and assume that there exists an isometry 
 $\phi \colon C^1\to C^2$
 (with
$\phi \colon C^1\to C^2$
 (with 
 $\phi (N^1)=N^2$
) covered by an isomorphism
$\phi (N^1)=N^2$
) covered by an isomorphism 
 $\Phi \colon {\mathtt {F}}^1|_{C^1} \to {\mathtt {F}}^2|_{C^2}$
, such that
$\Phi \colon {\mathtt {F}}^1|_{C^1} \to {\mathtt {F}}^2|_{C^2}$
, such that 
 $\mathcal {D}^1|_{C^1} \Phi ^* = \Phi ^* \mathcal {D}^2|_{C^2}$
 and
$\mathcal {D}^1|_{C^1} \Phi ^* = \Phi ^* \mathcal {D}^2|_{C^2}$
 and 
 $\mathcal {S}^2(\phi (x)) = \mathcal {S}^1(x)$
 for all
$\mathcal {S}^2(\phi (x)) = \mathcal {S}^1(x)$
 for all 
 $x\in C^1$
.
$x\in C^1$
.
 We will identify 
 $C^1$
 with
$C^1$
 with 
 $C^2$
 (as well as
$C^2$
 (as well as 
 $N^1$
 with
$N^1$
 with 
 $N^2$
) via
$N^2$
) via 
 $\phi $
, and we simply write C (and N). Define two new Riemannian manifolds
$\phi $
, and we simply write C (and N). Define two new Riemannian manifolds 
 $$ \begin{align*} M^3 &:= \overline U^1 \cup_N \overline V^2 , & M^4 &:= \overline U^2 \cup_N \overline V^1. \end{align*} $$
$$ \begin{align*} M^3 &:= \overline U^1 \cup_N \overline V^2 , & M^4 &:= \overline U^2 \cup_N \overline V^1. \end{align*} $$
Moreover, we glue the bundles using 
 $\Phi $
 to obtain hermitian vector bundles
$\Phi $
 to obtain hermitian vector bundles 
 ${\mathtt {F}}^3\to M^3$
 and
${\mathtt {F}}^3\to M^3$
 and 
 ${\mathtt {F}}^4\to M^4$
. For
${\mathtt {F}}^4\to M^4$
. For 
 $j=3,4$
, we then obtain corresponding operators
$j=3,4$
, we then obtain corresponding operators 
 $\mathcal {D}^j$
 and
$\mathcal {D}^j$
 and 
 $\mathcal {S}^j(\cdot )$
 satisfying assumption (A).
$\mathcal {S}^j(\cdot )$
 satisfying assumption (A).
Theorem 4.1 (Relative index theorem).
 Assume that 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^j$
 (for
$\widetilde {\mathcal {D}}_{\mathcal {S}}^j$
 (for 
 $j=1,2$
) are regular self-adjoint Fredholm operators with locally compact resolvents. Then
$j=1,2$
) are regular self-adjoint Fredholm operators with locally compact resolvents. Then 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 and
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 and 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 are also regular self-adjoint Fredholm operators with locally compact resolvents. Moreover, we have the equality
$\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 are also regular self-adjoint Fredholm operators with locally compact resolvents. Moreover, we have the equality 
 $$\begin{align*}{\mathrm{Index}} \big( \mathcal{D}^1 - i \mathcal{S}^1(\cdot) \big) + {\mathrm{Index}} \big( \mathcal{D}^2 - i \mathcal{S}^2(\cdot) \big) = {\mathrm{Index}} \big( \mathcal{D}^3 - i \mathcal{S}^3(\cdot) \big) + {\mathrm{Index}} \big( \mathcal{D}^4 - i \mathcal{S}^4(\cdot) \big) \in K_0(A). \end{align*}$$
$$\begin{align*}{\mathrm{Index}} \big( \mathcal{D}^1 - i \mathcal{S}^1(\cdot) \big) + {\mathrm{Index}} \big( \mathcal{D}^2 - i \mathcal{S}^2(\cdot) \big) = {\mathrm{Index}} \big( \mathcal{D}^3 - i \mathcal{S}^3(\cdot) \big) + {\mathrm{Index}} \big( \mathcal{D}^4 - i \mathcal{S}^4(\cdot) \big) \in K_0(A). \end{align*}$$
Proof. First, we need to check that 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 and
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 and 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 are also regular self-adjoint and Fredholm. We give the proof only for
$\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 are also regular self-adjoint and Fredholm. We give the proof only for 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
. We choose smooth functions
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
. We choose smooth functions 
 $\chi _1$
 and
$\chi _1$
 and 
 $\chi _2$
 such that
$\chi _2$
 such that 
 $$ \begin{align*} {\mathrm{supp}} \chi_1 &\subset U^1 \cup C , & {\mathrm{supp}} \chi_2 &\subset V^2 \cup C , & \chi_1^2 + \chi_2^2 &= 1. \end{align*} $$
$$ \begin{align*} {\mathrm{supp}} \chi_1 &\subset U^1 \cup C , & {\mathrm{supp}} \chi_2 &\subset V^2 \cup C , & \chi_1^2 + \chi_2^2 &= 1. \end{align*} $$
For 
 $\lambda>0$
, we define
$\lambda>0$
, we define 
 $$\begin{align*}R_\pm(\lambda) := \chi_1 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^1 \pm i\lambda \big)^{-1} \chi_1 + \chi_2 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^2 \pm i\lambda \big)^{-1} \chi_2. \end{align*}$$
$$\begin{align*}R_\pm(\lambda) := \chi_1 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^1 \pm i\lambda \big)^{-1} \chi_1 + \chi_2 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^2 \pm i\lambda \big)^{-1} \chi_2. \end{align*}$$
Then
 $$\begin{align*}\big( \widetilde{\mathcal{D}}_{\mathcal{S}}^3 \pm i\lambda \big) R_\pm(\lambda) = 1 + [\widetilde{\mathcal{D}}^1,\chi_1] \big(\widetilde{\mathcal{D}}_{\mathcal{S}}^1\pm i\lambda\big)^{-1} \chi_1 + [\widetilde{\mathcal{D}}^2,\chi_2] \big(\widetilde{\mathcal{D}}_{\mathcal{S}}^2\pm i\lambda\big)^{-1} \chi_2 =: 1 + \mathcal{K}_\pm(\lambda). \end{align*}$$
$$\begin{align*}\big( \widetilde{\mathcal{D}}_{\mathcal{S}}^3 \pm i\lambda \big) R_\pm(\lambda) = 1 + [\widetilde{\mathcal{D}}^1,\chi_1] \big(\widetilde{\mathcal{D}}_{\mathcal{S}}^1\pm i\lambda\big)^{-1} \chi_1 + [\widetilde{\mathcal{D}}^2,\chi_2] \big(\widetilde{\mathcal{D}}_{\mathcal{S}}^2\pm i\lambda\big)^{-1} \chi_2 =: 1 + \mathcal{K}_\pm(\lambda). \end{align*}$$
We can pick 
 $\lambda $
 sufficiently large, such that the norm of
$\lambda $
 sufficiently large, such that the norm of 
 $\mathcal {K}_\pm (\lambda )$
 is less than one. Then
$\mathcal {K}_\pm (\lambda )$
 is less than one. Then 
 $1+\mathcal {K}_\pm (\lambda )$
 is invertible, and
$1+\mathcal {K}_\pm (\lambda )$
 is invertible, and 
 $R_\pm (\lambda )(1+\mathcal {K}_\pm (\lambda ))^{-1}$
 is a right inverse of
$R_\pm (\lambda )(1+\mathcal {K}_\pm (\lambda ))^{-1}$
 is a right inverse of 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3\pm i\lambda $
. Similarly, we can also obtain a left inverse, which proves that
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3\pm i\lambda $
. Similarly, we can also obtain a left inverse, which proves that 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 is regular self-adjoint. Moreover, since
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 is regular self-adjoint. Moreover, since 
 $R_\pm (\lambda )$
 is locally compact, we see that
$R_\pm (\lambda )$
 is locally compact, we see that 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 has locally compact resolvents.
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 has locally compact resolvents.
 Next, given parametrices 
 $Q_1$
 and
$Q_1$
 and 
 $Q_2$
 for
$Q_2$
 for 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^1$
 and
$\widetilde {\mathcal {D}}_{\mathcal {S}}^1$
 and 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^2$
, respectively, we define
$\widetilde {\mathcal {D}}_{\mathcal {S}}^2$
, respectively, we define 
 $$\begin{align*}Q_3 := \chi_1 Q_1 \chi_1 + \chi_2 Q_2 \chi_2. \end{align*}$$
$$\begin{align*}Q_3 := \chi_1 Q_1 \chi_1 + \chi_2 Q_2 \chi_2. \end{align*}$$
Then
 $$\begin{align*}\widetilde{\mathcal{D}}_{\mathcal{S}}^3 Q_3 - 1 = \chi_1 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^1 Q_1 - 1 \big) \chi_1 + [\widetilde{\mathcal{D}}^1,\chi_1] Q_1 \chi_1 + \chi_2 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^2 Q_2 - 1 \big) \chi_2 + [\widetilde{\mathcal{D}}^2,\chi_2] Q_2 \chi_2. \end{align*}$$
$$\begin{align*}\widetilde{\mathcal{D}}_{\mathcal{S}}^3 Q_3 - 1 = \chi_1 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^1 Q_1 - 1 \big) \chi_1 + [\widetilde{\mathcal{D}}^1,\chi_1] Q_1 \chi_1 + \chi_2 \big( \widetilde{\mathcal{D}}_{\mathcal{S}}^2 Q_2 - 1 \big) \chi_2 + [\widetilde{\mathcal{D}}^2,\chi_2] Q_2 \chi_2. \end{align*}$$
The terms 
 $\chi _j \big ( \widetilde {\mathcal {D}}_{\mathcal {S}}^j Q_j - 1 \big ) \chi _j$
 are compact because
$\chi _j \big ( \widetilde {\mathcal {D}}_{\mathcal {S}}^j Q_j - 1 \big ) \chi _j$
 are compact because 
 $Q_j$
 are parametrices. Furthermore, the terms
$Q_j$
 are parametrices. Furthermore, the terms 
 $[\widetilde {\mathcal {D}}^j,\chi _j] Q_j \chi _j$
 are compact because
$[\widetilde {\mathcal {D}}^j,\chi _j] Q_j \chi _j$
 are compact because 
 $[\widetilde {\mathcal {D}}^j,\chi _j]$
 are compactly supported and
$[\widetilde {\mathcal {D}}^j,\chi _j]$
 are compactly supported and 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^j$
 have locally compact resolvents. Hence,
$\widetilde {\mathcal {D}}_{\mathcal {S}}^j$
 have locally compact resolvents. Hence, 
 $Q_3$
 is a right parametrix for
$Q_3$
 is a right parametrix for 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
. A similar calculation shows that
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
. A similar calculation shows that 
 $Q_3$
 is also a left parametrix, and therefore,
$Q_3$
 is also a left parametrix, and therefore, 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 is Fredholm. Similarly, the operator
$\widetilde {\mathcal {D}}_{\mathcal {S}}^3$
 is Fredholm. Similarly, the operator 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 is also regular self-adjoint and Fredholm. The proof of the equality
$\widetilde {\mathcal {D}}_{\mathcal {S}}^4$
 is also regular self-adjoint and Fredholm. The proof of the equality 
 $ {\mathrm {Index}} \big ( \mathcal {D}^1 - i \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^2 - i \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^3 - i \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \mathcal {S}^4(\cdot ) \big ) \in K_0(A)$
is then exactly as in [Reference van den DungenDun19, Theorem 4.7].
$ {\mathrm {Index}} \big ( \mathcal {D}^1 - i \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^2 - i \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^3 - i \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \mathcal {S}^4(\cdot ) \big ) \in K_0(A)$
is then exactly as in [Reference van den DungenDun19, Theorem 4.7].
4.2 The Fredholm index
 From here on, we consider M, 
 $\mathcal {D}$
 and
$\mathcal {D}$
 and 
 $\mathcal {S}(\cdot )$
 satisfying assumptions (A) and (B). Our aim in this subsection is to prove Theorem 3.4 (see Theorem 4.4 below). We first observe that, thanks to assumption (B), the operator
$\mathcal {S}(\cdot )$
 satisfying assumptions (A) and (B). Our aim in this subsection is to prove Theorem 3.4 (see Theorem 4.4 below). We first observe that, thanks to assumption (B), the operator 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}$
 has locally compact resolvents.
$\widetilde {\mathcal {D}}_{\mathcal {S}}$
 has locally compact resolvents.
Proposition 4.2 [Reference Kaad and LeschKL13, Theorem 6.7].
 The operator 
 $\phi (\widetilde {\mathcal {D}}_{\mathcal {S}}\pm i)^{-1}$
 on
$\phi (\widetilde {\mathcal {D}}_{\mathcal {S}}\pm i)^{-1}$
 on 
 $L^2(M,E\otimes {\mathtt {F}})^{\oplus 2}$
 is compact for any
$L^2(M,E\otimes {\mathtt {F}})^{\oplus 2}$
 is compact for any 
 $\phi \in C_0(M)$
. Moreover, if
$\phi \in C_0(M)$
. Moreover, if 
 $(\mathcal {S}(\cdot )\pm i)^{-1}$
 is compact on
$(\mathcal {S}(\cdot )\pm i)^{-1}$
 is compact on 
 $C_0(M,E)$
, then
$C_0(M,E)$
, then 
 $(\widetilde {\mathcal {D}}_{\mathcal {S}}\pm i)^{-1}$
 is also compact.
$(\widetilde {\mathcal {D}}_{\mathcal {S}}\pm i)^{-1}$
 is also compact.
 In order to prove the Fredholm property of 
 $\widetilde {\mathcal {D}}_{\mathcal {S}}$
, we need to rescale the potential
$\widetilde {\mathcal {D}}_{\mathcal {S}}$
, we need to rescale the potential 
 $\mathcal {S}(\cdot )$
 by a sufficiently large
$\mathcal {S}(\cdot )$
 by a sufficiently large 
 $\lambda>0$
. First, we need the following pointwise estimate.
$\lambda>0$
. First, we need the following pointwise estimate.
Lemma 4.3. There exist 
 $\lambda _0>0$
 and
$\lambda _0>0$
 and 
 $\epsilon>0$
 such that for any
$\epsilon>0$
 such that for any 
 $\lambda \geq \lambda _0$
, there exists a compactly supported smooth function
$\lambda \geq \lambda _0$
, there exists a compactly supported smooth function 
 $f \in C_c^\infty (M)$
 such that for all
$f \in C_c^\infty (M)$
 such that for all 
 $x\in M$
 and
$x\in M$
 and 
 $\psi (x) \in (W\otimes {\mathtt {F}})^{\oplus 2}$
, we have the inequality
$\psi (x) \in (W\otimes {\mathtt {F}})^{\oplus 2}$
, we have the inequality 

Proof. We roughly follow the proof of [Reference van den DungenDun19, Lemma 5.8], but with somewhat different estimates.
 First, since 
 $\lambda \mathcal {S}$
 also satisfies assumption (B), we know from Propositions 3.3 and 4.2 that
$\lambda \mathcal {S}$
 also satisfies assumption (B), we know from Propositions 3.3 and 4.2 that 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is regular self-adjoint and has locally compact resolvents. For any
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is regular self-adjoint and has locally compact resolvents. For any 
 $\alpha \in (0,\infty )$
,
$\alpha \in (0,\infty )$
, 
 $x\in M$
 and
$x\in M$
 and 
 $\psi (x) \in (W\otimes {\mathtt {F}})^{\oplus 2}$
, we have (using the same arguments as in the proof of [Reference Kaad and LeschKL12, Lemma 7.5])
$\psi (x) \in (W\otimes {\mathtt {F}})^{\oplus 2}$
, we have (using the same arguments as in the proof of [Reference Kaad and LeschKL12, Lemma 7.5]) 

where 
 $\{\cdot ,\cdot \}$
 denotes the anti-commutator. Using that
$\{\cdot ,\cdot \}$
 denotes the anti-commutator. Using that 
 $\delta _x := \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
 is bounded, we obtain
$\delta _x := \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
 is bounded, we obtain 

We distinguish between the cases 
 $x\in M\setminus K$
 and
$x\in M\setminus K$
 and 
 $x\in K$
:
$x\in K$
: 
- 
 $\boldsymbol {x\in M\setminus K}$
: Let $\boldsymbol {x\in M\setminus K}$
: Let $c \equiv c_{M\setminus K} := \inf _{x\in M\setminus K} \|\mathcal {S}(x)^{-1}\|^{-1}$
. Then combining (4.1) with the norm inequality $c \equiv c_{M\setminus K} := \inf _{x\in M\setminus K} \|\mathcal {S}(x)^{-1}\|^{-1}$
. Then combining (4.1) with the norm inequality $\|(\widetilde {\mathcal {S}}(x)\pm i) \widetilde {\mathcal {S}}(x)^{-1}\| \leq 1+c^{-1}$
, we obtain $\|(\widetilde {\mathcal {S}}(x)\pm i) \widetilde {\mathcal {S}}(x)^{-1}\| \leq 1+c^{-1}$
, we obtain Now setting  $\alpha = \lambda ^{1/2} \delta _x^{-1} (1+c^{-1})^{-1}$
 yields and in particular $\alpha = \lambda ^{1/2} \delta _x^{-1} (1+c^{-1})^{-1}$
 yields and in particular  Thus, we have  Now set  $\delta _{M\setminus K} := \sup _{x\in M\setminus K} \delta _x = \sup _{x\in M\setminus K} \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
, and pick $\delta _{M\setminus K} := \sup _{x\in M\setminus K} \delta _x = \sup _{x\in M\setminus K} \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
, and pick $\lambda _0> 0$
 large enough such that $\lambda _0> 0$
 large enough such that $\epsilon := \frac 12 \big ( \lambda _0^2 c^2 - \delta _{M\setminus K}^2 (1+c^{-1})^2 \big )> 0$
. Then we have shown that for all $\epsilon := \frac 12 \big ( \lambda _0^2 c^2 - \delta _{M\setminus K}^2 (1+c^{-1})^2 \big )> 0$
. Then we have shown that for all $x\in M\setminus K$
 and all $x\in M\setminus K$
 and all $\lambda \geq \lambda _0$
, we have (4.2) $\lambda \geq \lambda _0$
, we have (4.2) 
- 
 $\boldsymbol {x\in K}$
: Set $\boldsymbol {x\in K}$
: Set $\delta _K := \sup _{x\in K} \delta _x = \sup _{x\in K} \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
, fix $\delta _K := \sup _{x\in K} \delta _x = \sup _{x\in K} \big \| \big [\mathcal {D},\mathcal {S}(\cdot )\big ](x) \big (\mathcal {S}(x)\pm i\big )^{-1} \big \|$
, fix $\lambda \geq \lambda _0$
 and pick a compactly supported smooth function $\lambda \geq \lambda _0$
 and pick a compactly supported smooth function $f \in C_c^\infty (M)$
 such that $f \in C_c^\infty (M)$
 such that $f(x)^2 \geq \epsilon + \frac 12 (\lambda ^2 + \delta _K^2)$
 for all $f(x)^2 \geq \epsilon + \frac 12 (\lambda ^2 + \delta _K^2)$
 for all $x\in K$
. Inserting $x\in K$
. Inserting $\alpha = \lambda ^{1/2} \delta _K^{-1}$
 into (4.1), we see that for any $\alpha = \lambda ^{1/2} \delta _K^{-1}$
 into (4.1), we see that for any $x\in K$
, we have and in particular $x\in K$
, we have and in particular  Thus, for any  $x\in K$
, we have (4.3) $x\in K$
, we have (4.3) 
Combining Equations (4.2) and (4.3), we have thus shown the desired inequality for any 
 $x\in M$
.
$x\in M$
.
Theorem 4.4.
- 
1. There exists  $\lambda _0>0$
 such that for any $\lambda _0>0$
 such that for any $\lambda \geq \lambda _0$
, the operator $\lambda \geq \lambda _0$
, the operator $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is Fredholm, and thus, $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is Fredholm, and thus, $\mathcal {D}_{\lambda \mathcal {S}}$
 is a generalised Dirac-Schrödinger operator. $\mathcal {D}_{\lambda \mathcal {S}}$
 is a generalised Dirac-Schrödinger operator.
- 
2. Suppose there exists a compact subset  $\hat K \supset K$
 such that $\hat K \supset K$
 such that $\hat \delta < \frac {\hat c^2}{\hat c+1}$
, where $\hat \delta < \frac {\hat c^2}{\hat c+1}$
, where $$ \begin{align*} \hat\delta &:= \sup_{x\in M\setminus\hat K} \big\| \big[\mathcal{D},\mathcal{S}(\cdot)\big](x) \big(\mathcal{S}(x)\pm i\big)^{-1} \big\| , & \hat c &:= \inf_{x\in M\setminus\hat K} \|\mathcal{S}(x)^{-1}\|^{-1}. \end{align*} $$ $$ \begin{align*} \hat\delta &:= \sup_{x\in M\setminus\hat K} \big\| \big[\mathcal{D},\mathcal{S}(\cdot)\big](x) \big(\mathcal{S}(x)\pm i\big)^{-1} \big\| , & \hat c &:= \inf_{x\in M\setminus\hat K} \|\mathcal{S}(x)^{-1}\|^{-1}. \end{align*} $$Then the first statement holds with  $\lambda _0=1$
. In particular, $\lambda _0=1$
. In particular, $\mathcal {D}_{\mathcal {S}}$
 is a generalised Dirac-Schrödinger operator. $\mathcal {D}_{\mathcal {S}}$
 is a generalised Dirac-Schrödinger operator.
Proof. Let 
 $\lambda \geq \lambda _0$
,
$\lambda \geq \lambda _0$
, 
 $\epsilon>0$
 and
$\epsilon>0$
 and 
 $f\in C_c^\infty (M)$
 be given by Lemma 4.3. For any
$f\in C_c^\infty (M)$
 be given by Lemma 4.3. For any 
 $\psi \in  {\mathrm {Dom}}(\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2)$
, we then compute
$\psi \in  {\mathrm {Dom}}(\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2)$
, we then compute 

where the inequality on the last line is given by Lemma 4.3. Hence, we have shown that the spectrum of 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2 + f^2$
 is contained in
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2 + f^2$
 is contained in 
 $[\epsilon ,\infty )$
, and therefore, we have a well-defined inverse
$[\epsilon ,\infty )$
, and therefore, we have a well-defined inverse 
 $\big (\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2 + f^2\big )^{-1} \in \mathcal {L}_A\big (L^2(M,E\otimes {\mathtt {F}})^{\oplus 2}\big )$
.
$\big (\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2 + f^2\big )^{-1} \in \mathcal {L}_A\big (L^2(M,E\otimes {\mathtt {F}})^{\oplus 2}\big )$
.
 We can then construct a parametrix for 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 as follows. Pick a smooth function
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 as follows. Pick a smooth function 
 $\chi \in C_c^\infty (M)$
 such that
$\chi \in C_c^\infty (M)$
 such that 
 $0\leq \chi \leq 1$
, and
$0\leq \chi \leq 1$
, and 
 $\chi (x)=1$
 for all
$\chi (x)=1$
 for all 
 $x\in  {\mathrm {supp}} f$
. Write
$x\in  {\mathrm {supp}} f$
. Write 
 $\chi ' := \sqrt {1-\chi ^2}$
. Using that
$\chi ' := \sqrt {1-\chi ^2}$
. Using that 
 $f\chi '=0$
, we calculate that
$f\chi '=0$
, we calculate that 
 $$ \begin{align*} \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \chi' \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi' &= [\widetilde{\mathcal{D}},\chi'] \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi' + (\chi')^2. \end{align*} $$
$$ \begin{align*} \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \chi' \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi' &= [\widetilde{\mathcal{D}},\chi'] \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi' + (\chi')^2. \end{align*} $$
Define the operator
 $$ \begin{align*} Q &:= \chi \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i\big)^{-1} \chi + \chi' \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi'. \end{align*} $$
$$ \begin{align*} Q &:= \chi \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i\big)^{-1} \chi + \chi' \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi'. \end{align*} $$
We then compute
 $$ \begin{align*} \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} Q - 1 &= \big[\widetilde{\mathcal{D}},\chi\big] (\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i)^{-1} \chi + i \chi (\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i)^{-1} \chi + \big[\widetilde{\mathcal{D}},\chi'\big] \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi'. \end{align*} $$
$$ \begin{align*} \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} Q - 1 &= \big[\widetilde{\mathcal{D}},\chi\big] (\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i)^{-1} \chi + i \chi (\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}-i)^{-1} \chi + \big[\widetilde{\mathcal{D}},\chi'\big] \widetilde{\mathcal{D}}_{\lambda\mathcal{S}} \big(\widetilde{\mathcal{D}}_{\lambda\mathcal{S}}^2+f^2\big)^{-1} \chi'. \end{align*} $$
The operators 
 $[\widetilde {\mathcal {D}},\chi ]$
 and
$[\widetilde {\mathcal {D}},\chi ]$
 and 
 $[\widetilde {\mathcal {D}},\chi ']$
 are smooth and compactly supported, and therefore bounded. Since
$[\widetilde {\mathcal {D}},\chi ']$
 are smooth and compactly supported, and therefore bounded. Since 
 $(\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}-i) \big (\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2+f^2\big )^{-\frac 12}$
 is also bounded, it follows from Proposition 4.2 that
$(\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}-i) \big (\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2+f^2\big )^{-\frac 12}$
 is also bounded, it follows from Proposition 4.2 that 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}} Q - 1$
 is compact. Hence, Q is a right parametrix for
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}} Q - 1$
 is compact. Hence, Q is a right parametrix for 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
. A similar calculation shows that Q is also a left parametrix, and therefore,
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
. A similar calculation shows that Q is also a left parametrix, and therefore, 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is Fredholm. We have thus proven the first statement.
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is Fredholm. We have thus proven the first statement.
 For the second statement, we note that we may replace K by the larger compact set 
 $\hat K$
. Using the inequality
$\hat K$
. Using the inequality 
 $\hat \delta < \frac {\hat c^2}{\hat c+1}$
, the proof of Lemma 4.3 (picking
$\hat \delta < \frac {\hat c^2}{\hat c+1}$
, the proof of Lemma 4.3 (picking 
 $\lambda _0=1$
) shows that for all
$\lambda _0=1$
) shows that for all 
 $x\in M\setminus \hat K$
, we have
$x\in M\setminus \hat K$
, we have 

for 
 $\epsilon := \frac 12 \big ( \hat c^2 - \hat \delta ^2 (1+\hat c^{-1})^2 \big )> 0$
. Thus, in this case, the first statement holds with
$\epsilon := \frac 12 \big ( \hat c^2 - \hat \delta ^2 (1+\hat c^{-1})^2 \big )> 0$
. Thus, in this case, the first statement holds with 
 $\lambda _0=1$
.
$\lambda _0=1$
.
Proposition 4.5. Suppose that 
 $\{\mathcal {S}(x)\}_{x\in M}$
 is uniformly invertible on all of M. Then there exists
$\{\mathcal {S}(x)\}_{x\in M}$
 is uniformly invertible on all of M. Then there exists 
 $\lambda _0>0$
 such that for any
$\lambda _0>0$
 such that for any 
 $\lambda \geq \lambda _0$
, the generalised Dirac-Schrödinger operator
$\lambda \geq \lambda _0$
, the generalised Dirac-Schrödinger operator 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is also invertible.
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
 is also invertible.
Proof. Since 
 $\mathcal {S}(\cdot )$
 is uniformly invertible, Equation (4.2) now holds for all
$\mathcal {S}(\cdot )$
 is uniformly invertible, Equation (4.2) now holds for all 
 $x\in M$
 (for
$x\in M$
 (for 
 $\lambda \geq \lambda _0>0$
), and therefore, Equation (4.4) holds with
$\lambda \geq \lambda _0>0$
), and therefore, Equation (4.4) holds with 
 $f\equiv 0$
, which shows that
$f\equiv 0$
, which shows that 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2$
 (and hence
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}^2$
 (and hence 
 $\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
) is invertible.
$\widetilde {\mathcal {D}}_{\lambda \mathcal {S}}$
) is invertible.
4.3 The index pairing
In this subsection, we will prove Theorem 3.5. Similarly to [Reference van den DungenDun19, Proposition 5.14], we show first that we can replace M by a manifold with cylindrical ends, without affecting the index of the generalised Dirac-Schrödinger operator.
Proposition 4.6. There exist a precompact open subset U of M and a generalised Dirac-Schrödinger operator 
 $\mathcal {D}_{\lambda \mathcal {S}}'$
 on
$\mathcal {D}_{\lambda \mathcal {S}}'$
 on 
 $M' := \overline U \cup _{\partial U} (\partial U \times [0,\infty ))$
 satisfying assumptions (A) and (B), such that
$M' := \overline U \cup _{\partial U} (\partial U \times [0,\infty ))$
 satisfying assumptions (A) and (B), such that 
- 
1. the operators  $\mathcal {D}'$
 and $\mathcal {D}'$
 and $\mathcal {S}'(\cdot )$
 on $\mathcal {S}'(\cdot )$
 on $M'$
 agree with $M'$
 agree with $\mathcal {D}$
 and $\mathcal {D}$
 and $\mathcal {S}(\cdot )$
 on M when restricted to U; $\mathcal {S}(\cdot )$
 on M when restricted to U;
- 
2. the metric and the operators  $\mathcal {D}'$
 and $\mathcal {D}'$
 and $\mathcal {S}'(\cdot )$
 on $\mathcal {S}'(\cdot )$
 on $M'$
 are of product form on $M'$
 are of product form on $\partial U \times [1,\infty )$
; $\partial U \times [1,\infty )$
;
- 
3. we have, for  $\lambda $
 sufficiently large, the equality $\lambda $
 sufficiently large, the equality $ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \in K_0(A)$
. $ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \in K_0(A)$
.
In particular, 
 $M'$
 is complete and
$M'$
 is complete and 
 $\mathcal {D}'$
 has bounded propagation speed.
$\mathcal {D}'$
 has bounded propagation speed.
Proof. The proof is similar to the proof of [Reference van den DungenDun19, Proposition 5.14] but requires some minor adaptations. For completeness, we include the details here.
 Let U be a precompact open neighbourhood of K, with smooth compact boundary 
 $\partial U$
. Consider the manifold
$\partial U$
. Consider the manifold 
 $M' := \overline U \cup _{\partial U} \big (\partial U\times [0,\infty )\big )$
 with cylindrical ends. For some
$M' := \overline U \cup _{\partial U} \big (\partial U\times [0,\infty )\big )$
 with cylindrical ends. For some 
 $0<\epsilon <1$
, let
$0<\epsilon <1$
, let 
 $C\simeq \partial U\times (-\epsilon ,\epsilon )$
 be a tubular neighbourhood of
$C\simeq \partial U\times (-\epsilon ,\epsilon )$
 be a tubular neighbourhood of 
 $\partial U$
, such that there exists a diffeomorphism
$\partial U$
, such that there exists a diffeomorphism 
 $\phi \colon U\cup C \to \overline U\cup _{\partial U}\big (\partial U\times [0,\epsilon )\big ) \subset M'$
 (which preserves the subset U). Equip
$\phi \colon U\cup C \to \overline U\cup _{\partial U}\big (\partial U\times [0,\epsilon )\big ) \subset M'$
 (which preserves the subset U). Equip 
 $M'$
 with a Riemannian metric which is of product form on
$M'$
 with a Riemannian metric which is of product form on 
 $\partial U\times [1,\infty )$
 (ensuring that
$\partial U\times [1,\infty )$
 (ensuring that 
 $M'$
 is complete), and which agrees with
$M'$
 is complete), and which agrees with 
 $g|_U$
 on U. Let
$g|_U$
 on U. Let 
 ${\mathtt {F}}'\to M'$
 be a hermitian vector bundle which agrees with
${\mathtt {F}}'\to M'$
 be a hermitian vector bundle which agrees with 
 ${\mathtt {F}}|_U$
 on U. Let
${\mathtt {F}}|_U$
 on U. Let 
 $\mathcal {D}'$
 be a symmetric elliptic first-order differential operator on
$\mathcal {D}'$
 be a symmetric elliptic first-order differential operator on 
 ${\mathtt {F}}'\to M'$
, which is of product form on
${\mathtt {F}}'\to M'$
, which is of product form on 
 $\partial U\times [1,\infty )$
, and which agrees with
$\partial U\times [1,\infty )$
, and which agrees with 
 $\mathcal {D}|_{U\cup C}$
 on
$\mathcal {D}|_{U\cup C}$
 on 
 $U\cup C$
. Then
$U\cup C$
. Then 
 $\mathcal {D}'$
 has bounded propagation speed and is essentially self-adjoint by [Reference Higson and RoeHR00, Proposition 10.2.11].
$\mathcal {D}'$
 has bounded propagation speed and is essentially self-adjoint by [Reference Higson and RoeHR00, Proposition 10.2.11].
 Let 
 $0<\delta <\epsilon $
 and let
$0<\delta <\epsilon $
 and let 
 $\chi \in C^\infty (\mathbb {R})$
 be such that
$\chi \in C^\infty (\mathbb {R})$
 be such that 
 $0 \leq \chi (r) \leq 1$
 for all
$0 \leq \chi (r) \leq 1$
 for all 
 $r\in \mathbb {R}$
,
$r\in \mathbb {R}$
, 
 $\chi (r) = 1$
 for all r in a neighbourhood of
$\chi (r) = 1$
 for all r in a neighbourhood of 
 $0$
, and
$0$
, and 
 $\chi (r) = 0$
 for all
$\chi (r) = 0$
 for all 
 $|r|> \delta $
. Consider the family
$|r|> \delta $
. Consider the family 
 $\{\mathcal {S}'(x)\}_{x\in M'}$
 given by
$\{\mathcal {S}'(x)\}_{x\in M'}$
 given by 
 $$\begin{align*}\mathcal{S}'(x) := \begin{cases} \mathcal{S}(x) , & x\in U , \\ \chi(r) \mathcal{S}(x) + (1-\chi(r)) \mathcal{S}(y) , & x=(r,y)\in [0,\infty)\times\partial U. \end{cases} \end{align*}$$
$$\begin{align*}\mathcal{S}'(x) := \begin{cases} \mathcal{S}(x) , & x\in U , \\ \chi(r) \mathcal{S}(x) + (1-\chi(r)) \mathcal{S}(y) , & x=(r,y)\in [0,\infty)\times\partial U. \end{cases} \end{align*}$$
We choose 
 $\delta $
 small enough such that
$\delta $
 small enough such that 
 $\chi (r) \mathcal {S}(y) + (1-\chi (r)) \mathcal {S}(x)$
 is invertible for all
$\chi (r) \mathcal {S}(y) + (1-\chi (r)) \mathcal {S}(x)$
 is invertible for all 
 $x\in [0,\delta ]\times \partial U$
. Then the family
$x\in [0,\delta ]\times \partial U$
. Then the family 
 $\{\mathcal {S}'(x)\}_{x\in M'}$
 also satisfies assumptions (A) and (B). Thus, we have constructed a Dirac-Schrödinger operator
$\{\mathcal {S}'(x)\}_{x\in M'}$
 also satisfies assumptions (A) and (B). Thus, we have constructed a Dirac-Schrödinger operator 
 $\mathcal {D}' - i \lambda \mathcal {S}'(\cdot )$
 on
$\mathcal {D}' - i \lambda \mathcal {S}'(\cdot )$
 on 
 $M'$
, satisfying the desired properties 1 and 2. It remains to prove the equality
$M'$
, satisfying the desired properties 1 and 2. It remains to prove the equality 
 $ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big )$
, for which we invoke the relative index theorem.
$ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big )$
, for which we invoke the relative index theorem.
 Let 
 $M^1 := M$
 and
$M^1 := M$
 and 
 $M^2 := \partial U \times \mathbb {R}$
. Let
$M^2 := \partial U \times \mathbb {R}$
. Let 
 $C' = \phi (C)$
 be the collar neighbourhood of
$C' = \phi (C)$
 be the collar neighbourhood of 
 $\partial U$
 in
$\partial U$
 in 
 $M'$
. We equip
$M'$
. We equip 
 $M^2$
 with a complete Riemannian metric which agrees with the metric of
$M^2$
 with a complete Riemannian metric which agrees with the metric of 
 $M'$
 on
$M'$
 on 
 $C' \cup \big (\partial U\times (0,\infty )\big )$
, and which is of product form on
$C' \cup \big (\partial U\times (0,\infty )\big )$
, and which is of product form on 
 $(-\infty ,-1]\times \partial U$
. We extend the vector bundle
$(-\infty ,-1]\times \partial U$
. We extend the vector bundle 
 ${\mathtt {F}}'|_{C'\cup (\partial U\times (0,\infty ))}$
 to a bundle
${\mathtt {F}}'|_{C'\cup (\partial U\times (0,\infty ))}$
 to a bundle 
 ${\mathtt {F}}^2\to M^2$
, and we pick an essentially self-adjoint elliptic first-order differential operator
${\mathtt {F}}^2\to M^2$
, and we pick an essentially self-adjoint elliptic first-order differential operator 
 $\mathcal {D}^2$
 on
$\mathcal {D}^2$
 on 
 ${\mathtt {F}}^2$
 such that
${\mathtt {F}}^2$
 such that 
 $\mathcal {D}^2|_{C'\cup (\partial U\times (0,\infty ))} = \mathcal {D}'|_{C'\cup (\partial U\times (0,\infty ))}$
 (for instance, we can take
$\mathcal {D}^2|_{C'\cup (\partial U\times (0,\infty ))} = \mathcal {D}'|_{C'\cup (\partial U\times (0,\infty ))}$
 (for instance, we can take 
 $\mathcal {D}^2$
 to be of product form on
$\mathcal {D}^2$
 to be of product form on 
 $(-\infty ,-1)\times \partial U$
). We define a family
$(-\infty ,-1)\times \partial U$
). We define a family 
 $\{\mathcal {S}^2(x)\}_{x\in M^2}$
 by
$\{\mathcal {S}^2(x)\}_{x\in M^2}$
 by 
 $\mathcal {S}^2(y,r) := \chi (r) \mathcal {S}(y,r) + (1-\chi (r)) \mathcal {S}(y)$
 for all
$\mathcal {S}^2(y,r) := \chi (r) \mathcal {S}(y,r) + (1-\chi (r)) \mathcal {S}(y)$
 for all 
 $y\in \partial U$
 and
$y\in \partial U$
 and 
 $r\in \mathbb {R}$
. Then
$r\in \mathbb {R}$
. Then 
 ${\mathtt {F}}^2\to M^2$
,
${\mathtt {F}}^2\to M^2$
, 
 $\mathcal {D}^2$
 and
$\mathcal {D}^2$
 and 
 $\mathcal {S}^2(\cdot )$
 satisfy assumptions (A) and (B). By cutting and pasting along
$\mathcal {S}^2(\cdot )$
 satisfy assumptions (A) and (B). By cutting and pasting along 
 $\partial U$
, we obtain manifolds
$\partial U$
, we obtain manifolds 
 $M^3 = M'$
 and
$M^3 = M'$
 and 
 $M^4 = \big (\partial U\times (-\infty ,0]\big ) \cup _{\partial U} (M\setminus U)$
, with corresponding operators
$M^4 = \big (\partial U\times (-\infty ,0]\big ) \cup _{\partial U} (M\setminus U)$
, with corresponding operators 
 $\mathcal {D}^3$
,
$\mathcal {D}^3$
, 
 $\mathcal {S}^3(\cdot )$
,
$\mathcal {S}^3(\cdot )$
, 
 $\mathcal {D}^4$
, and
$\mathcal {D}^4$
, and 
 $\mathcal {S}^4(\cdot )$
. By Theorem 4.1, we have
$\mathcal {S}^4(\cdot )$
. By Theorem 4.1, we have 
 $ {\mathrm {Index}} \big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big )$
. The potentials
$ {\mathrm {Index}} \big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big )$
. The potentials 
 $\mathcal {S}^2(\cdot )$
 and
$\mathcal {S}^2(\cdot )$
 and 
 $\mathcal {S}^4(\cdot )$
 are both uniformly invertible, so by Proposition 4.5, we have
$\mathcal {S}^4(\cdot )$
 are both uniformly invertible, so by Proposition 4.5, we have 
 $ {\mathrm {Index}} \big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big ) = 0$
 (for
$ {\mathrm {Index}} \big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big ) = 0$
 (for 
 $\lambda $
 sufficiently large). Since
$\lambda $
 sufficiently large). Since 
 $M^1 = M$
 and
$M^1 = M$
 and 
 $M^3 = M'$
, we conclude that
$M^3 = M'$
, we conclude that 
 $ {\mathrm {Index}} \big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
.
$ {\mathrm {Index}} \big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) =  {\mathrm {Index}} \big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
.
Proposition 4.7 (cf. [Reference van den DungenDun19, Proposition 5.10]).
 Let 
 $M'$
,
$M'$
, 
 $\mathcal {D}'$
 and
$\mathcal {D}'$
 and 
 $\mathcal {S}'(\cdot )$
 be as in Proposition 4.6. Then we have the equality
$\mathcal {S}'(\cdot )$
 be as in Proposition 4.6. Then we have the equality 
 $[\mathcal {S}'(\cdot )] \otimes _{C_0(M')} [\mathcal {D}'] =  {\mathrm {Index}} \big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
.
$[\mathcal {S}'(\cdot )] \otimes _{C_0(M')} [\mathcal {D}'] =  {\mathrm {Index}} \big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
.
Proof. This follows basically from [Reference van den DungenDun19, Proposition 5.10]; however, there it was assumed that the graph norms of 
 $\mathcal {S}'(x)$
 are uniformly equivalent and that the weak derivative
$\mathcal {S}'(x)$
 are uniformly equivalent and that the weak derivative 
 $d\mathcal {S}'(\cdot )$
 is uniformly bounded. Together with the bounded propagation speed of
$d\mathcal {S}'(\cdot )$
 is uniformly bounded. Together with the bounded propagation speed of 
 $\mathcal {D}'$
, this implies the boundedness of
$\mathcal {D}'$
, this implies the boundedness of 
 $\big [\mathcal {D}',\mathcal {S}'(\cdot )\big ] \big (\mathcal {S}'(\cdot )\pm i\big )^{-1}$
, as explained in Remark 3.2.3. The proofs given in [Reference van den DungenDun19, §5.1] actually only rely on this boundedness of
$\big [\mathcal {D}',\mathcal {S}'(\cdot )\big ] \big (\mathcal {S}'(\cdot )\pm i\big )^{-1}$
, as explained in Remark 3.2.3. The proofs given in [Reference van den DungenDun19, §5.1] actually only rely on this boundedness of 
 $\big [\mathcal {D}',\mathcal {S}'(\cdot )\big ] \big (\mathcal {S}'(\cdot )\pm i\big )^{-1}$
. As the latter is required by our assumption (B2), the proof of [Reference van den DungenDun19, Proposition 5.10] follows through and the statement follows.
$\big [\mathcal {D}',\mathcal {S}'(\cdot )\big ] \big (\mathcal {S}'(\cdot )\pm i\big )^{-1}$
. As the latter is required by our assumption (B2), the proof of [Reference van den DungenDun19, Proposition 5.10] follows through and the statement follows.
We are now ready to prove:
Theorem 3.5. Let M be a connected Riemannian manifold, and let 
 $\{\mathcal {S}(x)\}_{x\in M}$
 and
$\{\mathcal {S}(x)\}_{x\in M}$
 and 
 $\mathcal {D}$
 satisfy assumptions (A) and (B). Then there exists
$\mathcal {D}$
 satisfy assumptions (A) and (B). Then there exists 
 $\lambda _0>0$
 such that for any
$\lambda _0>0$
 such that for any 
 $\lambda \geq \lambda _0$
, the
$\lambda \geq \lambda _0$
, the 
 $K_0(A)$
-valued index of
$K_0(A)$
-valued index of 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 equals the pairing of
$\mathcal {D}_{\lambda \mathcal {S}}$
 equals the pairing of 
 $[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 with
$[\mathcal {S}(\cdot )] \in K_1(C_0(M,A))$
 with 
 $[\mathcal {D}] \in K^1(C_0(M))$
.
$[\mathcal {D}] \in K^1(C_0(M))$
.
Proof. From Proposition 4.6, we obtain a complete manifold 
 $M'$
 and a generalised Dirac-Schrödinger operator satisfying assumptions (A) and (B), such that
$M'$
 and a generalised Dirac-Schrödinger operator satisfying assumptions (A) and (B), such that 
 $\mathcal {D}'$
 has bounded propagation speed, and such that
$\mathcal {D}'$
 has bounded propagation speed, and such that 
 $ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \in K_0(A)$
 (for
$ {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \in K_0(A)$
 (for 
 $\lambda $
 sufficiently large). As in the proof of [Reference van den DungenDun19, Theorem 5.15], we have
$\lambda $
 sufficiently large). As in the proof of [Reference van den DungenDun19, Theorem 5.15], we have 
 $$\begin{align*}[\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}(\cdot)|_U] \otimes_{C_0(U)} [\mathcal{D}|_U] = [\mathcal{S}'(\cdot)] \otimes_{C_0(M')} [\mathcal{D}']. \end{align*}$$
$$\begin{align*}[\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}(\cdot)|_U] \otimes_{C_0(U)} [\mathcal{D}|_U] = [\mathcal{S}'(\cdot)] \otimes_{C_0(M')} [\mathcal{D}']. \end{align*}$$
Moreover, we know from Proposition 4.7 that 
 $[\mathcal {S}'(\cdot )] \otimes _{C_0(M')} [\mathcal {D}'] =  {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
. Altogether, we conclude that
$[\mathcal {S}'(\cdot )] \otimes _{C_0(M')} [\mathcal {D}'] =  {\mathrm {Index}}\big ( \mathcal {D}' - i \lambda \mathcal {S}'(\cdot ) \big )$
. Altogether, we conclude that 
 $$\begin{align*}[\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}'(\cdot)] \otimes_{C_0(M')} [\mathcal{D}'] = {\mathrm{Index}}\big( \mathcal{D}' - i \lambda\mathcal{S}'(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}(\cdot) \big).\\[-37pt] \end{align*}$$
$$\begin{align*}[\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}'(\cdot)] \otimes_{C_0(M')} [\mathcal{D}'] = {\mathrm{Index}}\big( \mathcal{D}' - i \lambda\mathcal{S}'(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}(\cdot) \big).\\[-37pt] \end{align*}$$
5 Proof of the main theorem
 Let M, 
 $\mathcal {D}$
 and
$\mathcal {D}$
 and 
 $\mathcal {S}(\cdot )$
 satisfy assumptions (A), (B) and (C), and consider the generalised Callias-type operator
$\mathcal {S}(\cdot )$
 satisfy assumptions (A), (B) and (C), and consider the generalised Callias-type operator 
 $\mathcal {D}_{\lambda \mathcal {S}}$
. We will show that we can replace the manifold M by a cylindrical manifold
$\mathcal {D}_{\lambda \mathcal {S}}$
. We will show that we can replace the manifold M by a cylindrical manifold 
 $\mathbb {R}\times N$
 without changing the index of
$\mathbb {R}\times N$
 without changing the index of 
 $\mathcal {D}_{\lambda \mathcal {S}}$
. Thus, we can reduce the proof of our generalised Callias Theorem (Theorem 3.8) from the general statement to the case of a cylindrical manifold. This reduction is made possible by the relative index theorem (Theorem 4.1).
$\mathcal {D}_{\lambda \mathcal {S}}$
. Thus, we can reduce the proof of our generalised Callias Theorem (Theorem 3.8) from the general statement to the case of a cylindrical manifold. This reduction is made possible by the relative index theorem (Theorem 4.1).
Lemma 5.1. We may replace the collar neighbourhood C by a smaller collar neighbourhood 
 $C' \simeq (-2\varepsilon ',2\varepsilon ')\times N$
 (with
$C' \simeq (-2\varepsilon ',2\varepsilon ')\times N$
 (with 
 $0 < \varepsilon ' < \varepsilon $
) and the potential
$0 < \varepsilon ' < \varepsilon $
) and the potential 
 $\mathcal {S}(\cdot )$
 by a potential
$\mathcal {S}(\cdot )$
 by a potential 
 $\mathcal {S}'(\cdot )$
 satisfying the following:
$\mathcal {S}'(\cdot )$
 satisfying the following: 
- 
• for all  $x\in K\setminus C'$
: $x\in K\setminus C'$
: $\mathcal {S}'(x) = \mathcal {T}$
; $\mathcal {S}'(x) = \mathcal {T}$
;
- 
• for all  $x=(r,y) \in C'$
: $x=(r,y) \in C'$
: $\mathcal {S}'(x) = \varrho (r) \mathcal {T} + \big (1-\varrho (r)\big ) \mathcal {S}(y)$
, for some function $\mathcal {S}'(x) = \varrho (r) \mathcal {T} + \big (1-\varrho (r)\big ) \mathcal {S}(y)$
, for some function $\varrho \in C^\infty (\mathbb {R})$
 such that $\varrho \in C^\infty (\mathbb {R})$
 such that $0 \leq \varrho (r) \leq 1$
 for all $0 \leq \varrho (r) \leq 1$
 for all $r\in \mathbb {R}$
, $r\in \mathbb {R}$
, $\varrho (r)=1$
 for all r in a neighbourhood of $\varrho (r)=1$
 for all r in a neighbourhood of $(-\infty ,-\varepsilon ']$
, and $(-\infty ,-\varepsilon ']$
, and $\varrho (r)=0$
 for all r in a neighbourhood of $\varrho (r)=0$
 for all r in a neighbourhood of $[0,\infty )$
, $[0,\infty )$
,
such that 
 $[\mathcal {S}(\cdot )] = [\mathcal {S}'(\cdot )] \in K_1(C_0(M,A))$
 and (for
$[\mathcal {S}(\cdot )] = [\mathcal {S}'(\cdot )] \in K_1(C_0(M,A))$
 and (for 
 $\lambda $
 sufficiently large)
$\lambda $
 sufficiently large) 
 $ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}'(\cdot ) \big ) \in K_0(A)$
.
$ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}'(\cdot ) \big ) \in K_0(A)$
.
Proof.
- 
1. In a first step, we replace  $\mathcal {S}(\cdot )$
 by a potential $\mathcal {S}(\cdot )$
 by a potential $\mathcal {S}"(\cdot )$
 which is of ‘product form’ near N. Let $\mathcal {S}"(\cdot )$
 which is of ‘product form’ near N. Let $0<\varepsilon '<\varepsilon /2$
 and let $0<\varepsilon '<\varepsilon /2$
 and let $\chi \in C^\infty (\mathbb {R})$
 be such that $\chi \in C^\infty (\mathbb {R})$
 be such that $0 \leq \chi (r) \leq 1$
 for all $0 \leq \chi (r) \leq 1$
 for all $r\in \mathbb {R}$
, $r\in \mathbb {R}$
, $\chi (r) = 1$
 for all $\chi (r) = 1$
 for all $|r|\leq 2\varepsilon '$
, and $|r|\leq 2\varepsilon '$
, and $\chi (r) = 0$
 for all $\chi (r) = 0$
 for all $|r|> 3\varepsilon '$
. Consider the family $|r|> 3\varepsilon '$
. Consider the family $\{\mathcal {S}"(x)\}_{x\in M}$
 given by $\{\mathcal {S}"(x)\}_{x\in M}$
 given by $$\begin{align*}\mathcal{S}"(x) := \begin{cases} \mathcal{S}(x) , & x\in M\setminus C , \\ \chi(r) \mathcal{S}(y) + (1-\chi(r)) \mathcal{S}(x) , & x=(r,y)\in C \simeq (-2\varepsilon,2\varepsilon)\times N. \end{cases} \end{align*}$$ $$\begin{align*}\mathcal{S}"(x) := \begin{cases} \mathcal{S}(x) , & x\in M\setminus C , \\ \chi(r) \mathcal{S}(y) + (1-\chi(r)) \mathcal{S}(x) , & x=(r,y)\in C \simeq (-2\varepsilon,2\varepsilon)\times N. \end{cases} \end{align*}$$We choose  $\varepsilon '$
 small enough such that $\varepsilon '$
 small enough such that $\chi (r) \mathcal {S}(y) + (1-\chi (r)) \mathcal {S}(x)$
 is invertible for all $\chi (r) \mathcal {S}(y) + (1-\chi (r)) \mathcal {S}(x)$
 is invertible for all $x\in [-3\varepsilon ',3\varepsilon ']\times N$
. Then $x\in [-3\varepsilon ',3\varepsilon ']\times N$
. Then $\mathcal {S}"(\cdot )$
 satisfies $\mathcal {S}"(\cdot )$
 satisfies $\mathcal {S}"(r,y) = \mathcal {S}(y) = \mathcal {S}"(0,y)$
 for all $\mathcal {S}"(r,y) = \mathcal {S}(y) = \mathcal {S}"(0,y)$
 for all $x=(r,y)$
 in the collar neighbourhood $x=(r,y)$
 in the collar neighbourhood $C'\simeq (-2\varepsilon ',2\varepsilon ')\times N$
 of N. Connecting $C'\simeq (-2\varepsilon ',2\varepsilon ')\times N$
 of N. Connecting $\mathcal {S}(\cdot )$
 and $\mathcal {S}(\cdot )$
 and $\mathcal {S}"(\cdot )$
 via a straight-line homotopy, we obtain $\mathcal {S}"(\cdot )$
 via a straight-line homotopy, we obtain $[\mathcal {S}"(\cdot )] = [\mathcal {S}(\cdot )]$
. Moreover, since $[\mathcal {S}"(\cdot )] = [\mathcal {S}(\cdot )]$
. Moreover, since $\mathcal {S}"(\cdot )$
 again satisfies assumptions (A) and (B), we can apply Theorem 3.5: there exist $\mathcal {S}"(\cdot )$
 again satisfies assumptions (A) and (B), we can apply Theorem 3.5: there exist $\lambda _0,\lambda _0"$
 such that for all $\lambda _0,\lambda _0"$
 such that for all $\lambda \geq \max \{\lambda _0,\lambda _0"\}$
, we have $\lambda \geq \max \{\lambda _0,\lambda _0"\}$
, we have $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}(\cdot) \big) \stackrel{\lambda\geq\lambda_0}{=} [\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}"(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] \stackrel{\lambda\geq\lambda_0"}{=} {\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}"(\cdot) \big). \end{align*}$$ $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}(\cdot) \big) \stackrel{\lambda\geq\lambda_0}{=} [\mathcal{S}(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] = [\mathcal{S}"(\cdot)] \otimes_{C_0(M)} [\mathcal{D}] \stackrel{\lambda\geq\lambda_0"}{=} {\mathrm{Index}}\big( \mathcal{D} - i \lambda\mathcal{S}"(\cdot) \big). \end{align*}$$
- 
2. Picking  $\varrho $
 as in the statement with $\varrho $
 as in the statement with $\varepsilon '$
 from step 1, we consider the potential $\varepsilon '$
 from step 1, we consider the potential $\mathcal {S}'(\cdot )$
 given by (5.1) $\mathcal {S}'(\cdot )$
 given by (5.1) $$ \begin{align} \mathcal{S}'(x) := \begin{cases} \mathcal{T} , & x\in K\setminus C' , \\ \varrho(r) \mathcal{T} + \big(1-\varrho(r)\big) \mathcal{S}(y) , & x=(r,y)\in C', \\ \mathcal{S}"(x) , & x\in M\setminus (K\cup C'). \end{cases} \end{align} $$ $$ \begin{align} \mathcal{S}'(x) := \begin{cases} \mathcal{T} , & x\in K\setminus C' , \\ \varrho(r) \mathcal{T} + \big(1-\varrho(r)\big) \mathcal{S}(y) , & x=(r,y)\in C', \\ \mathcal{S}"(x) , & x\in M\setminus (K\cup C'). \end{cases} \end{align} $$We note that  $\mathcal {S}'(\cdot )$
 again satisfies assumption (A) and therefore also defines a class $\mathcal {S}'(\cdot )$
 again satisfies assumption (A) and therefore also defines a class $[\mathcal {S}'(\cdot )] \in K_1(C_0(M,A))$
. The difference $[\mathcal {S}'(\cdot )] \in K_1(C_0(M,A))$
. The difference $\mathcal {S}'(x) - \mathcal {S}"(x)$
 is relatively $\mathcal {S}'(x) - \mathcal {S}"(x)$
 is relatively $\mathcal {S}"(x)$
-compact (by choice of $\mathcal {S}"(x)$
-compact (by choice of $\mathcal {T}$
) and vanishes outside of K. Moreover, by assumption (A2), we know that $\mathcal {T}$
) and vanishes outside of K. Moreover, by assumption (A2), we know that $\big ( \mathcal {S}"(x) \pm i \big ) \big ( \mathcal {T} \pm i \big )^{-1}$
 is norm-continuous in x, and consequently, the family of inverses $\big ( \mathcal {S}"(x) \pm i \big ) \big ( \mathcal {T} \pm i \big )^{-1}$
 is norm-continuous in x, and consequently, the family of inverses $\big ( \mathcal {T} \pm i \big ) \big ( \mathcal {S}"(x) \pm i \big )^{-1}$
 is also norm-continuous in x. Therefore, $\big ( \mathcal {T} \pm i \big ) \big ( \mathcal {S}"(x) \pm i \big )^{-1}$
 is also norm-continuous in x. Therefore, $\big ( \mathcal {S}'(x) - \mathcal {S}"(x) \big ) \big (\mathcal {S}"(x)\pm i\big )^{-1}$
 is norm-continuous in x. Hence, the family $\big ( \mathcal {S}'(x) - \mathcal {S}"(x) \big ) \big (\mathcal {S}"(x)\pm i\big )^{-1}$
 is norm-continuous in x. Hence, the family $\mathcal {S}'(\cdot ) - \mathcal {S}"(\cdot )$
 is relatively $\mathcal {S}'(\cdot ) - \mathcal {S}"(\cdot )$
 is relatively $\mathcal {S}"(\cdot )$
-compact, and it follows from Proposition A.11 that $\mathcal {S}"(\cdot )$
-compact, and it follows from Proposition A.11 that . .Next, since  $\mathcal {S}'(\cdot )$
 again satisfies assumption (B), we can again apply Theorem 3.5, and as in step 1, we obtain (for $\mathcal {S}'(\cdot )$
 again satisfies assumption (B), we can again apply Theorem 3.5, and as in step 1, we obtain (for $\lambda $
 sufficiently large) that $\lambda $
 sufficiently large) that $ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}"(\cdot ) \big )$
. $ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}'(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}"(\cdot ) \big )$
.
Definition 5.2. Consider the cylindrical manifold 
 $\mathbb {R}\times N$
, along with the pullback vector bundle
$\mathbb {R}\times N$
, along with the pullback vector bundle 
 ${\mathtt {F}}_{\mathbb {R}\times N}$
 obtained from
${\mathtt {F}}_{\mathbb {R}\times N}$
 obtained from 
 ${\mathtt {F}}_N\to N$
. We identify
${\mathtt {F}}_N\to N$
. We identify 
 $\Gamma _c^\infty ({\mathtt {F}}_{\mathbb {R}\times N}) \simeq C_c^\infty (\mathbb {R}) \otimes \Gamma ^\infty ({\mathtt {F}}_N)$
 and consider the essentially self-adjoint elliptic first-order differential operator
$\Gamma _c^\infty ({\mathtt {F}}_{\mathbb {R}\times N}) \simeq C_c^\infty (\mathbb {R}) \otimes \Gamma ^\infty ({\mathtt {F}}_N)$
 and consider the essentially self-adjoint elliptic first-order differential operator 
 $\mathcal {D}_{\mathbb {R}\times N}$
 on
$\mathcal {D}_{\mathbb {R}\times N}$
 on 
 ${\mathtt {F}}_{\mathbb {R}\times N}$
 given by
${\mathtt {F}}_{\mathbb {R}\times N}$
 given by 
 $$ \begin{align*} \mathcal{D}_{\mathbb{R}\times N} := -i\partial_r \otimes \Gamma_N + 1 \otimes \mathcal{D}_N. \end{align*} $$
$$ \begin{align*} \mathcal{D}_{\mathbb{R}\times N} := -i\partial_r \otimes \Gamma_N + 1 \otimes \mathcal{D}_N. \end{align*} $$
Let 
 $\varrho \in C^\infty (\mathbb {R})$
 be as in Lemma 5.1. We define the family
$\varrho \in C^\infty (\mathbb {R})$
 be as in Lemma 5.1. We define the family 
 $\{\mathcal {S}_{\mathbb {R}\times N}(r,y)\}_{(r,y)\in \mathbb {R}\times N}$
 on E given by
$\{\mathcal {S}_{\mathbb {R}\times N}(r,y)\}_{(r,y)\in \mathbb {R}\times N}$
 on E given by 
 $$ \begin{align*} \mathcal{S}_{\mathbb{R}\times N}(r,y) := \varrho(r) \mathcal{T} + \big(1-\varrho(r)\big) \mathcal{S}(y). \end{align*} $$
$$ \begin{align*} \mathcal{S}_{\mathbb{R}\times N}(r,y) := \varrho(r) \mathcal{T} + \big(1-\varrho(r)\big) \mathcal{S}(y). \end{align*} $$
 The operator 
 $\Gamma _N$
 from assumption (C1) provides a
$\Gamma _N$
 from assumption (C1) provides a 
 $\mathbb {Z}_2$
-grading on
$\mathbb {Z}_2$
-grading on 
 ${\mathtt {F}}_N$
, yielding the decomposition
${\mathtt {F}}_N$
, yielding the decomposition 
 ${\mathtt {F}}_N = {\mathtt {F}}_N^+ \oplus {\mathtt {F}}_N^-$
. By assumption, the essentially self-adjoint elliptic first-order differential operator
${\mathtt {F}}_N = {\mathtt {F}}_N^+ \oplus {\mathtt {F}}_N^-$
. By assumption, the essentially self-adjoint elliptic first-order differential operator 
 $\mathcal {D}_N$
 is odd with respect to this
$\mathcal {D}_N$
 is odd with respect to this 
 $\mathbb {Z}_2$
-grading, and thus,
$\mathbb {Z}_2$
-grading, and thus, 
 $\mathcal {D}_N$
 defines an even K-homology class
$\mathcal {D}_N$
 defines an even K-homology class 
 $[\mathcal {D}_N] \in K^{0}(C(N)) \equiv K_0(N)$
. Similarly, the ungraded operator
$[\mathcal {D}_N] \in K^{0}(C(N)) \equiv K_0(N)$
. Similarly, the ungraded operator 
 $\mathcal {D}_{\mathbb {R}\times N}$
 yields an odd K-homology class
$\mathcal {D}_{\mathbb {R}\times N}$
 yields an odd K-homology class 
 $[\mathcal {D}_{\mathbb {R}\times N}] \in K^1(C_0(\mathbb {R}\times N)) \equiv K_1(\mathbb {R}\times N)$
. Furthermore, the operator
$[\mathcal {D}_{\mathbb {R}\times N}] \in K^1(C_0(\mathbb {R}\times N)) \equiv K_1(\mathbb {R}\times N)$
. Furthermore, the operator 
 $-i\partial _r$
 on
$-i\partial _r$
 on 
 $L^2(\mathbb {R})$
 yields an odd K-homology class
$L^2(\mathbb {R})$
 yields an odd K-homology class 
 $[-i\partial _r] \in K^1(C_0(\mathbb {R})) \equiv K_1(\mathbb {R})$
.
$[-i\partial _r] \in K^1(C_0(\mathbb {R})) \equiv K_1(\mathbb {R})$
.
Lemma 5.3. The external product of 
 $[-i\partial _r] \in K^1(C_0(\mathbb {R}))$
 with
$[-i\partial _r] \in K^1(C_0(\mathbb {R}))$
 with 
 $[\mathcal {D}_N] \in K^{0}(C(N))$
 equals
$[\mathcal {D}_N] \in K^{0}(C(N))$
 equals 
 $[\mathcal {D}_{\mathbb {R}\times N}] \in K^1(C_0(\mathbb {R}\times N))$
.
$[\mathcal {D}_{\mathbb {R}\times N}] \in K^1(C_0(\mathbb {R}\times N))$
.
Proof. The statement follows from the description of the odd-even (internal) Kasparov product given in [Reference Brain, Mesland and van SuijlekomBMS16, Example 2.38] (noting that the argument remains valid in the simpler case of an external Kasparov product).
Theorem 5.4. Consider the cylindrical manifold 
 $\mathbb {R}\times N$
 with the operators
$\mathbb {R}\times N$
 with the operators 
 $\mathcal {D}_{\mathbb {R}\times N}$
 and
$\mathcal {D}_{\mathbb {R}\times N}$
 and 
 $\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 from Definition 4.2. Then, for
$\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 from Definition 4.2. Then, for 
 $\lambda $
 sufficiently large,
$\lambda $
 sufficiently large, 
 $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big). \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big). \end{align*}$$
Proof. Using Lemma 5.1, we may assume that the potential 
 $\mathcal {S}(\cdot )$
 agrees with the potential
$\mathcal {S}(\cdot )$
 agrees with the potential 
 $\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 on the collar neighbourhood C of N and that
$\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 on the collar neighbourhood C of N and that 
 $\mathcal {S}(x)=\mathcal {T}$
 for all
$\mathcal {S}(x)=\mathcal {T}$
 for all 
 $x\in K\setminus C$
. We will then apply the relative index theorem (Theorem 4.1) twice.
$x\in K\setminus C$
. We will then apply the relative index theorem (Theorem 4.1) twice.
 First, define 
 $V := M\setminus K$
, and consider the manifolds
$V := M\setminus K$
, and consider the manifolds 
 $$ \begin{align*} M^1 &\equiv M = K \cup_{N} \overline V, & M^2 &:= \mathbb{R}\times N = \big((-\infty,0]\times N\big) \cup_{\{0\}\times N} \big([0,\infty)\times N\big). \end{align*} $$
$$ \begin{align*} M^1 &\equiv M = K \cup_{N} \overline V, & M^2 &:= \mathbb{R}\times N = \big((-\infty,0]\times N\big) \cup_{\{0\}\times N} \big([0,\infty)\times N\big). \end{align*} $$
On 
 $M^2$
, we consider the operator
$M^2$
, we consider the operator 
 $\mathcal {D}^2 := \mathcal {D}_{\mathbb {R}\times N}$
 and the potential
$\mathcal {D}^2 := \mathcal {D}_{\mathbb {R}\times N}$
 and the potential 
 $\mathcal {S}^2(r,y) := \mathcal {S}(y)$
, satisfying assumptions (A) and (B). We identify N in M with
$\mathcal {S}^2(r,y) := \mathcal {S}(y)$
, satisfying assumptions (A) and (B). We identify N in M with 
 $\{0\}\times N$
 in
$\{0\}\times N$
 in 
 $M^2$
. Cutting and pasting then gives us two new manifolds
$M^2$
. Cutting and pasting then gives us two new manifolds 
 $M^3 = K \cup _{N} \big ([0,\infty )\times N\big )$
 and
$M^3 = K \cup _{N} \big ([0,\infty )\times N\big )$
 and 
 $M^4 = \big ((-\infty ,0]\times N\big ) \cup _{N} \overline V$
. Using the relative index theorem, we know that
$M^4 = \big ((-\infty ,0]\times N\big ) \cup _{N} \overline V$
. Using the relative index theorem, we know that 
 $ {\mathrm {Index}}\big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}}\big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}}\big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big ) \in K_0(A)$
 (for
$ {\mathrm {Index}}\big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) +  {\mathrm {Index}}\big ( \mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) +  {\mathrm {Index}}\big ( \mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot ) \big ) \in K_0(A)$
 (for 
 $\lambda $
 sufficiently large). Since
$\lambda $
 sufficiently large). Since 
 $\mathcal {S}^2(\cdot )$
 and
$\mathcal {S}^2(\cdot )$
 and 
 $\mathcal {S}^4(\cdot )$
 are invertible, we know from Proposition 4.5 that also
$\mathcal {S}^4(\cdot )$
 are invertible, we know from Proposition 4.5 that also 
 $\mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot )$
 and
$\mathcal {D}^2 - i \lambda \mathcal {S}^2(\cdot )$
 and 
 $\mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot )$
 are invertible (for
$\mathcal {D}^4 - i \lambda \mathcal {S}^4(\cdot )$
 are invertible (for 
 $\lambda $
 sufficiently large), and it follows that
$\lambda $
 sufficiently large), and it follows that 
 $ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \equiv  {\mathrm {Index}}\big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) \in K_0(A)$
. Thus, we have replaced the subset V by the half cylinder
$ {\mathrm {Index}}\big ( \mathcal {D} - i \lambda \mathcal {S}(\cdot ) \big ) \equiv  {\mathrm {Index}}\big ( \mathcal {D}^1 - i \lambda \mathcal {S}^1(\cdot ) \big ) =  {\mathrm {Index}}\big ( \mathcal {D}^3 - i \lambda \mathcal {S}^3(\cdot ) \big ) \in K_0(A)$
. Thus, we have replaced the subset V by the half cylinder 
 $(0,\infty )\times N$
, with the potential
$(0,\infty )\times N$
, with the potential 
 $\mathcal {S}_{\mathbb {R}\times N}(r,y) = \mathcal {S}(y)$
 for all
$\mathcal {S}_{\mathbb {R}\times N}(r,y) = \mathcal {S}(y)$
 for all 
 $r\in (0,\infty )$
.
$r\in (0,\infty )$
.
 Second, we can similarly apply the relative index theorem again to replace the subset 
 $K \backslash \big ([-\varepsilon ,0]\times N\big )$
 by the half cylinder
$K \backslash \big ([-\varepsilon ,0]\times N\big )$
 by the half cylinder 
 $(-\infty ,-\varepsilon )\times N$
, equipped with the constant potential
$(-\infty ,-\varepsilon )\times N$
, equipped with the constant potential 
 $\mathcal {S}_{\mathbb {R}\times N}(r,y) = \mathcal {T}$
 for all
$\mathcal {S}_{\mathbb {R}\times N}(r,y) = \mathcal {T}$
 for all 
 $r\in (-\infty ,-\varepsilon )$
,
$r\in (-\infty ,-\varepsilon )$
, 
 $y\in N$
. This completes the proof.
$y\in N$
. This completes the proof.
We are now ready to prove our main theorem.
Theorem 3.8 (Generalised Callias Theorem).
 Let 
 $\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Then we have the equality
$\mathcal {D}_{\lambda \mathcal {S}}$
 be a generalised Callias-type operator. Then we have the equality 
 $$ \begin{align*} {\mathrm{Index}} \big( \mathcal{D}_{\lambda\mathcal{S}} \big) = {\text{rel-ind}} \big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A), \end{align*} $$
$$ \begin{align*} {\mathrm{Index}} \big( \mathcal{D}_{\lambda\mathcal{S}} \big) = {\text{rel-ind}} \big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] \in K_0(A), \end{align*} $$
where 
 $\otimes _{C(N)}$
 denotes the pairing
$\otimes _{C(N)}$
 denotes the pairing 
 $K_1(C(N,A)) \times K^1(C(N)) \to K_0(A)$
.
$K_1(C(N,A)) \times K^1(C(N)) \to K_0(A)$
.
Proof. Consider the cylindrical manifold 
 $\mathbb {R}\times N$
 with the operators
$\mathbb {R}\times N$
 with the operators 
 $\mathcal {D}_{\mathbb {R}\times N}$
 and
$\mathcal {D}_{\mathbb {R}\times N}$
 and 
 $\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 from Definition 4.2. From Proposition 2.8, we have the equality
$\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 from Definition 4.2. From Proposition 2.8, we have the equality 
 $$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) = \text{sf} \big( \{\mathcal{S}_{\mathbb{R}\times N}(r)\}_{r\in[-\epsilon,0]} \big). \end{align*}$$
$$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) = \text{sf} \big( \{\mathcal{S}_{\mathbb{R}\times N}(r)\}_{r\in[-\epsilon,0]} \big). \end{align*}$$
Moreover, by [Reference van den DungenDun19, Proposition 2.21], the spectral flow of the family 
 $\{\mathcal {S}_{\mathbb {R}\times N}(r)\}_{r\in [-\epsilon ,0]}$
 equals
$\{\mathcal {S}_{\mathbb {R}\times N}(r)\}_{r\in [-\epsilon ,0]}$
 equals 
 $[\mathcal {S}_{\mathbb {R}\times N}(\cdot )] \otimes _{C_0(\mathbb {R})} [-i\partial _r]$
, so we obtain
$[\mathcal {S}_{\mathbb {R}\times N}(\cdot )] \otimes _{C_0(\mathbb {R})} [-i\partial _r]$
, so we obtain 
 $$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) = [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_r]. \end{align*}$$
$$\begin{align*}{\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) = [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_r]. \end{align*}$$
 For 
 $C^*$
-algebras A, B and C, recall the map
$C^*$
-algebras A, B and C, recall the map  given by the external Kasparov product with the identity element
 given by the external Kasparov product with the identity element  . Applying this with
. Applying this with 
 $C=C(N)$
, we then have the equalities
$C=C(N)$
, we then have the equalities 
 $$ \begin{align*} {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] &= \Big( [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_r] \Big) \otimes_{C(N)} [\mathcal{D}_N] \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} \tau_{C(N)}([-i\partial_r]) \otimes_{C(N)} [\mathcal{D}_N] \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} \Big( [-i\partial_r] \otimes [\mathcal{D}_N] \Big) \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} [\mathcal{D}_{\mathbb{R}\times N}] , \end{align*} $$
$$ \begin{align*} {\text{rel-ind}}\big(P_+(\mathcal{S}_N(\cdot)),P_+(\mathcal{T}(\cdot))\big) \otimes_{C(N)} [\mathcal{D}_N] &= \Big( [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R})} [-i\partial_r] \Big) \otimes_{C(N)} [\mathcal{D}_N] \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} \tau_{C(N)}([-i\partial_r]) \otimes_{C(N)} [\mathcal{D}_N] \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} \Big( [-i\partial_r] \otimes [\mathcal{D}_N] \Big) \\ &= [\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} [\mathcal{D}_{\mathbb{R}\times N}] , \end{align*} $$
where the second and third equalities follow from the properties of the Kasparov product, and the fourth equality is given by Lemma 5.3.
 Since the operators 
 $\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 and
$\mathcal {S}_{\mathbb {R}\times N}(\cdot )$
 and 
 $\mathcal {D}_{\mathbb {R}\times N}$
 on the manifold
$\mathcal {D}_{\mathbb {R}\times N}$
 on the manifold 
 $\mathbb {R}\times N$
 satisfy the assumptions (A) and (B), we may apply Theorem 3.5 to compute the Kasparov product on the manifold
$\mathbb {R}\times N$
 satisfy the assumptions (A) and (B), we may apply Theorem 3.5 to compute the Kasparov product on the manifold 
 $\mathbb {R}\times N$
 and obtain
$\mathbb {R}\times N$
 and obtain 
 $$\begin{align*}[\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} [\mathcal{D}_{\mathbb{R}\times N}] = {\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big). \end{align*}$$
$$\begin{align*}[\mathcal{S}_{\mathbb{R}\times N}(\cdot)] \otimes_{C_0(\mathbb{R}\times N)} [\mathcal{D}_{\mathbb{R}\times N}] = {\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big). \end{align*}$$
Finally, from Theorem 5.4, we know that
 $$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big).\\[-37pt] \end{align*}$$
$$\begin{align*}{\mathrm{Index}}\big( \mathcal{D}_{\mathbb{R}\times N} - i \lambda \mathcal{S}_{\mathbb{R}\times N}(\cdot) \big) = {\mathrm{Index}}\big( \mathcal{D} - i \lambda \mathcal{S}(\cdot) \big).\\[-37pt] \end{align*}$$
A Appendix
In this Appendix, we collect several statements regarding (mostly unbounded) operators on Hilbert 
 $C^*$
-modules. Many of these statements are well-known for operators on Hilbert spaces, but they have not yet appeared (to the author’s best knowledge) in the literature for operators on Hilbert
$C^*$
-modules. Many of these statements are well-known for operators on Hilbert spaces, but they have not yet appeared (to the author’s best knowledge) in the literature for operators on Hilbert 
 $C^*$
-modules. While some of the proofs of these statements are similar to proofs in the Hilbert space context, we have for completeness included detailed proofs in our Hilbert
$C^*$
-modules. While some of the proofs of these statements are similar to proofs in the Hilbert space context, we have for completeness included detailed proofs in our Hilbert 
 $C^*$
-module context.
$C^*$
-module context.
 Throughout this Appendix, we consider a 
 $C^*$
-algebra A and a Hilbert A-module E. We start with a basic lemma (well-known in the Hilbert space setting), whose proof given in, for example, [Reference Hislop and SigalHS12, Theorem 9.19], remains valid for adjointable operators on Hilbert
$C^*$
-algebra A and a Hilbert A-module E. We start with a basic lemma (well-known in the Hilbert space setting), whose proof given in, for example, [Reference Hislop and SigalHS12, Theorem 9.19], remains valid for adjointable operators on Hilbert 
 $C^*$
-modules.
$C^*$
-modules.
Lemma A.1. Let 
 $T_n \xrightarrow {*s} T \in \mathcal {L}_A(E)$
 be a
$T_n \xrightarrow {*s} T \in \mathcal {L}_A(E)$
 be a 
 $*$
-strongly convergent sequence of adjointable operators on E. Then for any compact operator
$*$
-strongly convergent sequence of adjointable operators on E. Then for any compact operator 
 $K \in \mathcal {K}_A(E)$
, we have norm-convergence
$K \in \mathcal {K}_A(E)$
, we have norm-convergence 
 $KT_n \to KT$
 and
$KT_n \to KT$
 and 
 $T_nK \to TK$
.
$T_nK \to TK$
.
Proof. For any 
 $\epsilon>0$
, there exists a finite-rank operator
$\epsilon>0$
, there exists a finite-rank operator 
 $F_\epsilon = \sum _{j=1}^N \theta _{\psi _j,\varphi _j}$
 such that
$F_\epsilon = \sum _{j=1}^N \theta _{\psi _j,\varphi _j}$
 such that 
 $\|K-F_\epsilon \| < \epsilon $
. For each
$\|K-F_\epsilon \| < \epsilon $
. For each 
 $\xi \in E$
, we can estimate
$\xi \in E$
, we can estimate 
 $$\begin{align*}\| (T_n-T) F_\epsilon \xi \| = \| (T_n-T) \sum_{j=1}^N \psi_j \langle \varphi_j | \xi \rangle \| \leq \sum_{j=1}^N \| (T_n-T) \psi_j \| \, \|\varphi_j\| \, \|\xi\|. \end{align*}$$
$$\begin{align*}\| (T_n-T) F_\epsilon \xi \| = \| (T_n-T) \sum_{j=1}^N \psi_j \langle \varphi_j | \xi \rangle \| \leq \sum_{j=1}^N \| (T_n-T) \psi_j \| \, \|\varphi_j\| \, \|\xi\|. \end{align*}$$
Since 
 $T_n\psi _j$
 converges to
$T_n\psi _j$
 converges to 
 $T\psi _j$
 for each j, we obtain for n large enough that
$T\psi _j$
 for each j, we obtain for n large enough that 
 $\| (T_n-T) F_\epsilon \| < \epsilon $
. Furthermore, since
$\| (T_n-T) F_\epsilon \| < \epsilon $
. Furthermore, since 
 $T_n$
 converges strongly to T, the uniform boundedness principle implies that there exists
$T_n$
 converges strongly to T, the uniform boundedness principle implies that there exists 
 $M\in (0,\infty )$
 such that
$M\in (0,\infty )$
 such that 
 $\|T_n\| \leq M$
 for all n. Thus, for n large enough, we obtain
$\|T_n\| \leq M$
 for all n. Thus, for n large enough, we obtain 
 $$\begin{align*}\|T_nK-TK\| \leq \|(T_n-T)(K-F_\epsilon)\| + \|(T_n-T)F_\epsilon\| \leq \epsilon \|T_n-T\| + \epsilon \leq \epsilon (M+\|T\|+1). \end{align*}$$
$$\begin{align*}\|T_nK-TK\| \leq \|(T_n-T)(K-F_\epsilon)\| + \|(T_n-T)F_\epsilon\| \leq \epsilon \|T_n-T\| + \epsilon \leq \epsilon (M+\|T\|+1). \end{align*}$$
As 
 $\epsilon>0$
 was arbitrary, this proves
$\epsilon>0$
 was arbitrary, this proves 
 $T_nK$
 converges to
$T_nK$
 converges to 
 $TK$
 in norm.
$TK$
 in norm.
 Next, using that 
 $T_n,T$
 are adjointable, we can also estimate, for any
$T_n,T$
 are adjointable, we can also estimate, for any 
 $\xi \in E$
,
$\xi \in E$
, 
 $$\begin{align*}\| F_\epsilon (T_n-T) \xi \| = \| \sum_{j=1}^N \psi_j \langle (T_n^*-T^*) \varphi_j | \xi \rangle \| \leq \sum_{j=1}^N \|\psi_j\| \, \| (T_n^*-T^*) \varphi_j \| \, \|\xi\|. \end{align*}$$
$$\begin{align*}\| F_\epsilon (T_n-T) \xi \| = \| \sum_{j=1}^N \psi_j \langle (T_n^*-T^*) \varphi_j | \xi \rangle \| \leq \sum_{j=1}^N \|\psi_j\| \, \| (T_n^*-T^*) \varphi_j \| \, \|\xi\|. \end{align*}$$
By assumption, 
 $T_n^*$
 also converges strongly to
$T_n^*$
 also converges strongly to 
 $T^*$
, so for n large enough, we obtain that
$T^*$
, so for n large enough, we obtain that 
 $\| F_\epsilon (T_n-T) \| < \epsilon $
. Then, proceeding as above, also
$\| F_\epsilon (T_n-T) \| < \epsilon $
. Then, proceeding as above, also 
 $KT_n$
 converges to
$KT_n$
 converges to 
 $KT$
 in norm.
$KT$
 in norm.
A.1 Interpolation
 The following results are based on [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Proposition A.1]. We follow the adaptation to the case of operators on Hilbert 
 $C^*$
-modules as given in the proof of [Reference Lesch and MeslandLM19, Lemma 7.7].
$C^*$
-modules as given in the proof of [Reference Lesch and MeslandLM19, Lemma 7.7].
Proposition A.2. Let T be an invertible positive regular self-adjoint operator on E. Let S be a densely defined symmetric operator on E with 
 $ {\mathrm {Dom}} S \supset  {\mathrm {Dom}} T$
. Then the following statements hold:
$ {\mathrm {Dom}} S \supset  {\mathrm {Dom}} T$
. Then the following statements hold: 
- 
1.  $ST^{-1}$
 is bounded and adjointable, and $ST^{-1}$
 is bounded and adjointable, and $T^{-1}S$
 is densely defined and bounded and extends to an adjointable operator $T^{-1}S$
 is densely defined and bounded and extends to an adjointable operator $\overline {T^{-1}S}$
 with $\overline {T^{-1}S}$
 with $(\overline {T^{-1}S})^* = ST^{-1}$
. $(\overline {T^{-1}S})^* = ST^{-1}$
.
- 
2. The operator  $T^{-1}ST$
 is densely defined, and its adjoint equals $T^{-1}ST$
 is densely defined, and its adjoint equals $(T^{-1}ST)^* = TST^{-1}$
. $(T^{-1}ST)^* = TST^{-1}$
.
- 
3. If  $T^{-1}ST$
 or $T^{-1}ST$
 or $TST^{-1}$
 is bounded and extends to an adjointable operator, then in fact both $TST^{-1}$
 is bounded and extends to an adjointable operator, then in fact both $T^{-1}ST$
 and $T^{-1}ST$
 and $TST^{-1}$
 are bounded and extend to adjointable operators, and $TST^{-1}$
 are bounded and extend to adjointable operators, and $\|\overline {TST^{-1}}\| = \|\overline {T^{-1}ST}\|$
. $\|\overline {TST^{-1}}\| = \|\overline {T^{-1}ST}\|$
.
- 
4. The operator  $T^{-\frac 12}ST^{-\frac 12}$
 is bounded and extends to an adjointable operator, and its norm satisfies the inequality $T^{-\frac 12}ST^{-\frac 12}$
 is bounded and extends to an adjointable operator, and its norm satisfies the inequality $\| T^{-\frac 12}ST^{-\frac 12} \| \leq \|ST^{-1}\|$
. $\| T^{-\frac 12}ST^{-\frac 12} \| \leq \|ST^{-1}\|$
.
Proof.
- 
1. Since S is closable and  $ {\mathrm {Ran}} T^{-1} \subset  {\mathrm {Dom}} S$
, it is a consequence of the closed graph theorem that $ {\mathrm {Ran}} T^{-1} \subset  {\mathrm {Dom}} S$
, it is a consequence of the closed graph theorem that $ST^{-1}$
 is bounded. For all $ST^{-1}$
 is bounded. For all $\psi \in  {\mathrm {Dom}} S$
 and $\psi \in  {\mathrm {Dom}} S$
 and $\xi \in E$
, we have $\xi \in E$
, we have $\langle T^{-1}S\psi |\xi \rangle = \langle \psi |ST^{-1}\xi \rangle $
, which shows that $\langle T^{-1}S\psi |\xi \rangle = \langle \psi |ST^{-1}\xi \rangle $
, which shows that $T^{-1}S$
 has a densely defined adjoint and is therefore closable. Moreover, on the dense subset $T^{-1}S$
 has a densely defined adjoint and is therefore closable. Moreover, on the dense subset $ {\mathrm {Dom}} S$
, $ {\mathrm {Dom}} S$
, $T^{-1}S$
 agrees with the adjoint $T^{-1}S$
 agrees with the adjoint $(ST^{-1})^*$
. Thus, $(ST^{-1})^*$
. Thus, $ST^{-1}$
 is bounded and has a densely defined adjoint, which implies that $ST^{-1}$
 is bounded and has a densely defined adjoint, which implies that $ST^{-1}$
 is in fact adjointable with $ST^{-1}$
 is in fact adjointable with $(ST^{-1})^* = \overline {T^{-1}S}$
. $(ST^{-1})^* = \overline {T^{-1}S}$
.
- 
2. Since T is regular and self-adjoint,  $ {\mathrm {Dom}} T^2$
 is dense in E, so $ {\mathrm {Dom}} T^2$
 is dense in E, so $ {\mathrm {Dom}}(T^{-1}ST) =  {\mathrm {Dom}}(ST) \supset  {\mathrm {Dom}}(T^2)$
 is also dense. Let $ {\mathrm {Dom}}(T^{-1}ST) =  {\mathrm {Dom}}(ST) \supset  {\mathrm {Dom}}(T^2)$
 is also dense. Let $\xi \in  {\mathrm {Dom}}(TST^{-1})$
 and $\xi \in  {\mathrm {Dom}}(TST^{-1})$
 and $\eta \in  {\mathrm {Dom}}(T^{-1}ST)$
. Then $\eta \in  {\mathrm {Dom}}(T^{-1}ST)$
. Then $T^{-1}\xi \in  {\mathrm {Dom}} S$
 with $T^{-1}\xi \in  {\mathrm {Dom}} S$
 with $ST^{-1}\xi \in  {\mathrm {Dom}} T$
, and $ST^{-1}\xi \in  {\mathrm {Dom}} T$
, and $\eta \in  {\mathrm {Dom}} T$
 with $\eta \in  {\mathrm {Dom}} T$
 with $T\eta \in  {\mathrm {Dom}} S$
. Consequently, so $T\eta \in  {\mathrm {Dom}} S$
. Consequently, so $$\begin{align*}\langle TST^{-1}\xi | \eta \rangle = \langle ST^{-1}\xi | T\eta \rangle = \langle T^{-1}\xi | ST\eta \rangle = \langle \xi | T^{-1}ST\eta \rangle , \end{align*}$$ $$\begin{align*}\langle TST^{-1}\xi | \eta \rangle = \langle ST^{-1}\xi | T\eta \rangle = \langle T^{-1}\xi | ST\eta \rangle = \langle \xi | T^{-1}ST\eta \rangle , \end{align*}$$ $\xi \in  {\mathrm {Dom}}(T^{-1}ST)^*$
 and $\xi \in  {\mathrm {Dom}}(T^{-1}ST)^*$
 and $TST^{-1} \subset (T^{-1}ST)^*$
. For the converse, consider $TST^{-1} \subset (T^{-1}ST)^*$
. For the converse, consider $\xi \in  {\mathrm {Dom}}(T^{-1}ST)^*$
 and $\xi \in  {\mathrm {Dom}}(T^{-1}ST)^*$
 and $\eta \in  {\mathrm {Dom}}(T^2) \subset  {\mathrm {Dom}}(T^{-1}ST)$
. Then $\eta \in  {\mathrm {Dom}}(T^2) \subset  {\mathrm {Dom}}(T^{-1}ST)$
. Then $$\begin{align*}\langle (T^{-1}ST)^*\xi | \eta \rangle = \langle \xi | T^{-1}ST\eta \rangle = \langle T^{-1}\xi | ST\eta \rangle = \langle ST^{-1}\xi | T\eta \rangle. \end{align*}$$ $$\begin{align*}\langle (T^{-1}ST)^*\xi | \eta \rangle = \langle \xi | T^{-1}ST\eta \rangle = \langle T^{-1}\xi | ST\eta \rangle = \langle ST^{-1}\xi | T\eta \rangle. \end{align*}$$Since  $ {\mathrm {Dom}} T^2$
 is a core for T, the above equality continues to hold for all $ {\mathrm {Dom}} T^2$
 is a core for T, the above equality continues to hold for all $\eta \in  {\mathrm {Dom}} T$
. Thus, $\eta \in  {\mathrm {Dom}} T$
. Thus, $ST^{-1}\xi \in  {\mathrm {Dom}} T^* =  {\mathrm {Dom}} T$
 and $ST^{-1}\xi \in  {\mathrm {Dom}} T^* =  {\mathrm {Dom}} T$
 and $TST^{-1}\xi = T^*ST^{-1}\xi = (T^{-1}ST)^*\xi $
, which shows $TST^{-1}\xi = T^*ST^{-1}\xi = (T^{-1}ST)^*\xi $
, which shows $(T^{-1}ST)^* \subset TST^{-1}$
. $(T^{-1}ST)^* \subset TST^{-1}$
.
- 
3. Assuming  $\overline {T^{-1}ST}$
 is adjointable, it follows from 2 that $\overline {T^{-1}ST}$
 is adjointable, it follows from 2 that $TST^{-1} = (\overline {T^{-1}ST})^*$
 is also bounded and adjointable. Similarly, assuming $TST^{-1} = (\overline {T^{-1}ST})^*$
 is also bounded and adjointable. Similarly, assuming $\overline {TST^{-1}}$
 is adjointable, it follows from 2 that $\overline {TST^{-1}}$
 is adjointable, it follows from 2 that $\overline {T^{-1}ST} = (\overline {TST^{-1}})^*$
 is also bounded and adjointable. $\overline {T^{-1}ST} = (\overline {TST^{-1}})^*$
 is also bounded and adjointable.
- 
4. For simplicity, we assume that  $\|T^{-1}\| \leq 1$
. For $\|T^{-1}\| \leq 1$
. For $\xi ,\eta \in  {\mathrm {Dom}} T$
 and $\xi ,\eta \in  {\mathrm {Dom}} T$
 and $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
, consider the operator $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
, consider the operator $P_z := T^{-z} S T^{-1+z}$
 and the function f is weakly holomorphic on the strip $P_z := T^{-z} S T^{-1+z}$
 and the function f is weakly holomorphic on the strip $$\begin{align*}f(z) := \langle P_z \xi | \eta \rangle = \langle T^{-z} S T^{-1+z} \xi | \eta \rangle. \end{align*}$$ $$\begin{align*}f(z) := \langle P_z \xi | \eta \rangle = \langle T^{-z} S T^{-1+z} \xi | \eta \rangle. \end{align*}$$ $0<{\mathop {\mathrm {Re}}} z<1$
. Moreover, from the estimate we obtain that $0<{\mathop {\mathrm {Re}}} z<1$
. Moreover, from the estimate we obtain that  $\|f(z)\| \leq \|ST^{-1}\| \, \|T\xi \| \, \|\eta \|$
, so f is a bounded function. $\|f(z)\| \leq \|ST^{-1}\| \, \|T\xi \| \, \|\eta \|$
, so f is a bounded function.Now consider a bounded linear functional  $\varphi \colon A \to \mathbb {C}$
 with $\varphi \colon A \to \mathbb {C}$
 with $\|\varphi \|\leq 1$
. Since the function $\|\varphi \|\leq 1$
. Since the function $\varphi \circ f$
 is holomorphic and bounded on the strip $\varphi \circ f$
 is holomorphic and bounded on the strip $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
, it follows from the Hadamard 3-line Theorem that $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
, it follows from the Hadamard 3-line Theorem that $\varphi \circ f$
 is bounded by its suprema on the boundary $\varphi \circ f$
 is bounded by its suprema on the boundary ${\mathop {\mathrm {Re}}} z \in \{0,1\}$
. On this boundary ${\mathop {\mathrm {Re}}} z \in \{0,1\}$
. On this boundary ${\mathop {\mathrm {Re}}} z \in \{0,1\}$
, we have ${\mathop {\mathrm {Re}}} z \in \{0,1\}$
, we have $\|P_z\| = \|P_0\| = \|ST^{-1}\|$
, so from the Hadamard 3-line Theorem, we obtain for all $\|P_z\| = \|P_0\| = \|ST^{-1}\|$
, so from the Hadamard 3-line Theorem, we obtain for all $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
 that $0\leq {\mathop {\mathrm {Re}}} z\leq 1$
 that $$ \begin{align*} \big| \varphi \big( f(z) \big) \big| = \big| \varphi \big( \langle P_z\xi | \eta \rangle \big) \big| &\leq \sup_{w\in\mathbb{C} : {\mathop{\text{Re}}} w=0,1} \big| \varphi \big( \langle P_w\xi | \eta \rangle \big) \big| \\ &\leq \sup_{w\in\mathbb{C} : {\mathop{\text{Re}}} w=0,1} \big\| \langle P_w\xi | \eta \rangle \big\| \leq \|ST^{-1}\| \, \|\xi\| \, \|\eta\|. \end{align*} $$ $$ \begin{align*} \big| \varphi \big( f(z) \big) \big| = \big| \varphi \big( \langle P_z\xi | \eta \rangle \big) \big| &\leq \sup_{w\in\mathbb{C} : {\mathop{\text{Re}}} w=0,1} \big| \varphi \big( \langle P_w\xi | \eta \rangle \big) \big| \\ &\leq \sup_{w\in\mathbb{C} : {\mathop{\text{Re}}} w=0,1} \big\| \langle P_w\xi | \eta \rangle \big\| \leq \|ST^{-1}\| \, \|\xi\| \, \|\eta\|. \end{align*} $$Since there exists a bounded linear functional  $\varphi $
 with $\varphi $
 with $\big | \varphi \big ( f(z) \big ) \big | = \| f(z) \|$
, it follows that also $\big | \varphi \big ( f(z) \big ) \big | = \| f(z) \|$
, it follows that also $\big \| f(z) \big \| \leq \|ST^{-1}\| \, \|\xi \| \, \|\eta \|$
. Taking the supremum over all $\big \| f(z) \big \| \leq \|ST^{-1}\| \, \|\xi \| \, \|\eta \|$
. Taking the supremum over all $\xi $
 and $\xi $
 and $\eta $
 with $\eta $
 with $\|\xi \|=\|\eta \|=1$
, we conclude that $\|\xi \|=\|\eta \|=1$
, we conclude that $P_z$
 is bounded and extends to an adjointable operator $P_z$
 is bounded and extends to an adjointable operator $\overline {P_z}$
 satisfying $\overline {P_z}$
 satisfying $\|\overline {P_z}\| \leq \|ST^{-1}\|$
. $\|\overline {P_z}\| \leq \|ST^{-1}\|$
.
Corollary A.3. Let T be an invertible positive regular self-adjoint operator on E. Let 
 $F=F^*\in \mathcal {L}_A(E)$
 and assume that the operator
$F=F^*\in \mathcal {L}_A(E)$
 and assume that the operator 
 $T^{-\frac 12} F T^{\frac 12}$
 is bounded and extends to an adjointable operator. Then
$T^{-\frac 12} F T^{\frac 12}$
 is bounded and extends to an adjointable operator. Then 
 $$\begin{align*}\|F\| \leq \| \overline{T^{-\frac12} F T^{\frac12}} \| = \| \overline{T^{\frac12} F T^{-\frac12}} \|. \end{align*}$$
$$\begin{align*}\|F\| \leq \| \overline{T^{-\frac12} F T^{\frac12}} \| = \| \overline{T^{\frac12} F T^{-\frac12}} \|. \end{align*}$$
Proof. We note that 
 $T^{\frac 12}$
 is also an invertible positive regular selfadjoint operator. Certainly,
$T^{\frac 12}$
 is also an invertible positive regular selfadjoint operator. Certainly, 
 $ {\mathrm {Dom}} F = E \supset  {\mathrm {Dom}} T^{\frac 12}$
, and since
$ {\mathrm {Dom}} F = E \supset  {\mathrm {Dom}} T^{\frac 12}$
, and since 
 $T^{-\frac 12} F T^{\frac 12}$
 is bounded (and extends to an adjointable operator), we know from Proposition A.2.3 that also
$T^{-\frac 12} F T^{\frac 12}$
 is bounded (and extends to an adjointable operator), we know from Proposition A.2.3 that also 
 $T^{\frac 12} F T^{-\frac 12}$
 is bounded (and extends to an adjointable operator) and
$T^{\frac 12} F T^{-\frac 12}$
 is bounded (and extends to an adjointable operator) and 
 $\|T^{\frac 12} F T^{-\frac 12}\| = \|T^{-\frac 12} F T^{\frac 12}\|$
.
$\|T^{\frac 12} F T^{-\frac 12}\| = \|T^{-\frac 12} F T^{\frac 12}\|$
.
 Now consider the symmetric operator 
 $S := T^{\frac 12} F T^{\frac 12}$
. We have just seen that
$S := T^{\frac 12} F T^{\frac 12}$
. We have just seen that 
 $ST^{-1} = T^{\frac 12} F T^{-\frac 12}$
 is bounded (i.e.,
$ST^{-1} = T^{\frac 12} F T^{-\frac 12}$
 is bounded (i.e., 
 $ {\mathrm {Dom}} T \subset  {\mathrm {Dom}} S$
). Hence, by Proposition A.2.4, we find that
$ {\mathrm {Dom}} T \subset  {\mathrm {Dom}} S$
). Hence, by Proposition A.2.4, we find that 
 $$\begin{align*}\|F\| = \| T^{-\frac12} S T^{-\frac12} \| \stackrel{A.2.4}{\leq} \|ST^{-1}\| = \| T^{\frac12} F T^{-\frac12} \| \stackrel{A.2.3}{=} \| T^{-\frac12} F T^{\frac12} \|. \end{align*}$$
$$\begin{align*}\|F\| = \| T^{-\frac12} S T^{-\frac12} \| \stackrel{A.2.4}{\leq} \|ST^{-1}\| = \| T^{\frac12} F T^{-\frac12} \| \stackrel{A.2.3}{=} \| T^{-\frac12} F T^{\frac12} \|. \end{align*}$$
A.2 Convergence of unbounded operators
 The following result generalises one of the statements in [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Proposition 2.2], regarding convergence of unbounded operators with respect to certain topologies, to the context of regular operators on Hilbert 
 $C^*$
-modules.
$C^*$
-modules.
Proposition A.4. Let 
 $\mathcal {D}$
 be a regular selfadjoint operator on E. We view the domain
$\mathcal {D}$
 be a regular selfadjoint operator on E. We view the domain 
 $W :=  {\mathrm {Dom}}\mathcal {D} \subset E$
 as a Hilbert A-module with the graph norm. Let T and
$W :=  {\mathrm {Dom}}\mathcal {D} \subset E$
 as a Hilbert A-module with the graph norm. Let T and 
 $T_n$
 (for all
$T_n$
 (for all 
 $n\in \mathbb {N}$
) be regular selfadjoint operators on E with
$n\in \mathbb {N}$
) be regular selfadjoint operators on E with 
 $ {\mathrm {Dom}} T =  {\mathrm {Dom}} \mathcal {D}$
 and
$ {\mathrm {Dom}} T =  {\mathrm {Dom}} \mathcal {D}$
 and 
 $ {\mathrm {Dom}} T_n =  {\mathrm {Dom}} \mathcal {D}$
 for all
$ {\mathrm {Dom}} T_n =  {\mathrm {Dom}} \mathcal {D}$
 for all 
 $n\in \mathbb {N}$
.
$n\in \mathbb {N}$
.
 If 
 $(T_n-T)(\mathcal {D}+i)^{-1}$
 converges in norm to
$(T_n-T)(\mathcal {D}+i)^{-1}$
 converges in norm to 
 $0$
 as
$0$
 as 
 $n\to \infty $
, then also
$n\to \infty $
, then also 
 $F_{T_n}-F_T$
 converges in norm to
$F_{T_n}-F_T$
 converges in norm to 
 $0$
 as
$0$
 as 
 $n\to \infty $
.
$n\to \infty $
.
Proof. The proof is similar to the Hilbert space proof given in [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Proposition 2.2]. For completeness, we include the details here.
 We pick 
 $0<\epsilon <\frac 12$
. Since
$0<\epsilon <\frac 12$
. Since 
 $ {\mathrm {Dom}}\mathcal {D} =  {\mathrm {Dom}} T$
, we know that
$ {\mathrm {Dom}}\mathcal {D} =  {\mathrm {Dom}} T$
, we know that 
 $(\mathcal {D}+i)(T+i)^{-1}$
 is bounded, so there exists an
$(\mathcal {D}+i)(T+i)^{-1}$
 is bounded, so there exists an 
 $N_0\in \mathbb {N}$
 such that for all
$N_0\in \mathbb {N}$
 such that for all 
 $n\geq N_0$
, we have
$n\geq N_0$
, we have 
 $$\begin{align*}\big\| (T-T_n) (T+i)^{-1} \big\| \leq \epsilon \quad\text{and}\quad \big\| (T+i)^{-1} (T-T_n) \big\| \leq \epsilon. \end{align*}$$
$$\begin{align*}\big\| (T-T_n) (T+i)^{-1} \big\| \leq \epsilon \quad\text{and}\quad \big\| (T+i)^{-1} (T-T_n) \big\| \leq \epsilon. \end{align*}$$
Consequently, the operator 
 $(T+i)^{-1}(T_n+i) = 1 - (T+i)^{-1}(T-T_n)$
 is invertible, and from the Neumann series, we obtain the norm bound
$(T+i)^{-1}(T_n+i) = 1 - (T+i)^{-1}(T-T_n)$
 is invertible, and from the Neumann series, we obtain the norm bound 
 $$\begin{align*}\big\| (T_n+i)^{-1} (T+i) \big\| \leq \sum_{k=0}^\infty \epsilon^k = \frac{1}{1-\epsilon} < 2. \end{align*}$$
$$\begin{align*}\big\| (T_n+i)^{-1} (T+i) \big\| \leq \sum_{k=0}^\infty \epsilon^k = \frac{1}{1-\epsilon} < 2. \end{align*}$$
Thus, for all 
 $\psi \in E$
, we have (in the
$\psi \in E$
, we have (in the 
 $C^*$
-algebra A) the inequality
$C^*$
-algebra A) the inequality 

or equivalently, we have the operator inequality
 $$\begin{align*}(1+T_n^2)^{-1} \leq \frac{1}{(1-\epsilon)^2} (1+T^2)^{-1}. \end{align*}$$
$$\begin{align*}(1+T_n^2)^{-1} \leq \frac{1}{(1-\epsilon)^2} (1+T^2)^{-1}. \end{align*}$$
Furthermore, from the estimate 
 $\big \| (T+i)^{-1} (T_n+i) \big \| \leq 1+\epsilon $
, we similarly obtain the operator inequality
$\big \| (T+i)^{-1} (T_n+i) \big \| \leq 1+\epsilon $
, we similarly obtain the operator inequality 
 $$\begin{align*}(1+T^2)^{-1} \leq (1+\epsilon)^2 (1+T_n^2)^{-1}. \end{align*}$$
$$\begin{align*}(1+T^2)^{-1} \leq (1+\epsilon)^2 (1+T_n^2)^{-1}. \end{align*}$$
Thus, taking square roots, we have
 $$\begin{align*}\frac{1}{1+\epsilon} (1+T^2)^{-\frac12} \leq (1+T_n^2)^{-\frac12} \leq \frac{1}{1-\epsilon} (1+T^2)^{-\frac12}. \end{align*}$$
$$\begin{align*}\frac{1}{1+\epsilon} (1+T^2)^{-\frac12} \leq (1+T_n^2)^{-\frac12} \leq \frac{1}{1-\epsilon} (1+T^2)^{-\frac12}. \end{align*}$$
Subtracting 
 $(1+T^2)^{-\frac 12}$
 yields
$(1+T^2)^{-\frac 12}$
 yields 
 $$\begin{align*}-\frac{\epsilon}{1+\epsilon} (1+T^2)^{-\frac12} \leq (1+T_n^2)^{-\frac12} - (1+T^2)^{-\frac12} \leq \frac{\epsilon}{1-\epsilon} (1+T^2)^{-\frac12} , \end{align*}$$
$$\begin{align*}-\frac{\epsilon}{1+\epsilon} (1+T^2)^{-\frac12} \leq (1+T_n^2)^{-\frac12} - (1+T^2)^{-\frac12} \leq \frac{\epsilon}{1-\epsilon} (1+T^2)^{-\frac12} , \end{align*}$$
from which we obtain the norm estimate
 $$\begin{align*}\big\| (1+T^2)^{\frac14} (1+T_n^2)^{-\frac12} (1+T^2)^{\frac14} - 1 \big\| \leq \frac{\epsilon}{1-\epsilon}. \end{align*}$$
$$\begin{align*}\big\| (1+T^2)^{\frac14} (1+T_n^2)^{-\frac12} (1+T^2)^{\frac14} - 1 \big\| \leq \frac{\epsilon}{1-\epsilon}. \end{align*}$$
In particular, 
 $(1+T^2)^{\frac 14} (1+T_n^2)^{-\frac 12} (1+T^2)^{\frac 14}$
 is bounded. Since also
$(1+T^2)^{\frac 14} (1+T_n^2)^{-\frac 12} (1+T^2)^{\frac 14}$
 is bounded. Since also 
 $(1+T^2)^{-\frac 14} T_n (1+T^2)^{-\frac 14}$
 is bounded by Proposition A.2.4, the estimate
$(1+T^2)^{-\frac 14} T_n (1+T^2)^{-\frac 14}$
 is bounded by Proposition A.2.4, the estimate 
 $$\begin{align*}\big\| (1+T^2)^{-\frac14} F_{T_n} (1+T^2)^{\frac14} \big\| \leq \big\| (1+T^2)^{-\frac14} T_n (1+T^2)^{-\frac14} \big\| \; \big\| (1+T^2)^{\frac14} (1+T_n^2)^{-\frac12} (1+T^2)^{\frac14} \big\| \end{align*}$$
$$\begin{align*}\big\| (1+T^2)^{-\frac14} F_{T_n} (1+T^2)^{\frac14} \big\| \leq \big\| (1+T^2)^{-\frac14} T_n (1+T^2)^{-\frac14} \big\| \; \big\| (1+T^2)^{\frac14} (1+T_n^2)^{-\frac12} (1+T^2)^{\frac14} \big\| \end{align*}$$
shows that 
 $(1+T^2)^{-\frac 14} F_{T_n} (1+T^2)^{\frac 14}$
 is bounded. Thus, we can use Corollary A.3 to estimate the difference of the bounded transforms of T and
$(1+T^2)^{-\frac 14} F_{T_n} (1+T^2)^{\frac 14}$
 is bounded. Thus, we can use Corollary A.3 to estimate the difference of the bounded transforms of T and 
 $T_n$
 (for all
$T_n$
 (for all 
 $n\geq N_0$
):
$n\geq N_0$
): 

where we used that 
 $\epsilon <\frac 12$
. We note that this inequality still holds for all
$\epsilon <\frac 12$
. We note that this inequality still holds for all 
 $n\geq N_0$
. Since
$n\geq N_0$
. Since 
 $0<\epsilon <\frac 12$
 was arbitrary, this proves that
$0<\epsilon <\frac 12$
 was arbitrary, this proves that 
 $\big \| F_T - F_{T_n} \big \| \to 0$
 as
$\big \| F_T - F_{T_n} \big \| \to 0$
 as 
 $n\to \infty $
.
$n\to \infty $
.
A.3 Relatively compact perturbations
 In this subsection, we study relatively compact perturbations of regular self-adjoint operators. Propositions A.6 and A.7 below are well-known facts for operators on Hilbert spaces but appear not to be present in the literature on Hilbert 
 $C^*$
-modules.
$C^*$
-modules.
Definition A.5. Let T be a regular self-adjoint operator on E. A densely defined operator R on E is called relatively T-compact if 
 $ {\mathrm {Dom}}(T) \subset  {\mathrm {Dom}}(R)$
 and
$ {\mathrm {Dom}}(T) \subset  {\mathrm {Dom}}(R)$
 and 
 $R(T\pm i)^{-1}$
 is compact.
$R(T\pm i)^{-1}$
 is compact.
 The assumption 
 $ {\mathrm {Dom}}(T) \subset  {\mathrm {Dom}}(R)$
 implies that R is also relatively T-bounded. In fact, relative T-compactness implies that the relative T-bound can be chosen to be arbitrarily small. This is a well-known fact for operators on Hilbert spaces; we show next that this fact remains true on Hilbert
$ {\mathrm {Dom}}(T) \subset  {\mathrm {Dom}}(R)$
 implies that R is also relatively T-bounded. In fact, relative T-compactness implies that the relative T-bound can be chosen to be arbitrarily small. This is a well-known fact for operators on Hilbert spaces; we show next that this fact remains true on Hilbert 
 $C^*$
-modules, by adapting the proof of [Reference Hislop and SigalHS12, Theorem 14.2].
$C^*$
-modules, by adapting the proof of [Reference Hislop and SigalHS12, Theorem 14.2].
Proposition A.6. Let T be a regular self-adjoint operator on E, and let R be relatively T-compact. Then for all 
 $\epsilon>0$
, there exists
$\epsilon>0$
, there exists 
 $C_\epsilon \geq 0$
 such that for all
$C_\epsilon \geq 0$
 such that for all 
 $\psi \in  {\mathrm {Dom}}(T)$
, we have
$\psi \in  {\mathrm {Dom}}(T)$
, we have 
 $$\begin{align*}\| R\psi \| \leq \epsilon \|T\psi\| + C_\epsilon \|\psi\|. \end{align*}$$
$$\begin{align*}\| R\psi \| \leq \epsilon \|T\psi\| + C_\epsilon \|\psi\|. \end{align*}$$
Proof. We note that the operators 
 $(T-i)(T-in)^{-1}$
 converge
$(T-i)(T-in)^{-1}$
 converge 
 $*$
-strongly to
$*$
-strongly to 
 $0$
 as
$0$
 as 
 $n\to \infty $
 (this follows, for example, from [Reference Kaad and LeschKL12, Lemma 7.2]). We can write
$n\to \infty $
 (this follows, for example, from [Reference Kaad and LeschKL12, Lemma 7.2]). We can write 
 $$\begin{align*}R (T-in)^{-1} = R(T-i)^{-1} (T-i)(T-in)^{-1}. \end{align*}$$
$$\begin{align*}R (T-in)^{-1} = R(T-i)^{-1} (T-i)(T-in)^{-1}. \end{align*}$$
Since 
 $R(T-i)^{-1}$
 is compact and
$R(T-i)^{-1}$
 is compact and 
 $(T-i)(T-in)^{-1} \xrightarrow {*s} 0$
, the operator
$(T-i)(T-in)^{-1} \xrightarrow {*s} 0$
, the operator 
 $R (T-in)^{-1}$
 converges to
$R (T-in)^{-1}$
 converges to 
 $0$
 in norm by Lemma A.1. Thus, given any
$0$
 in norm by Lemma A.1. Thus, given any 
 $\epsilon>0$
, we can choose n large enough such that
$\epsilon>0$
, we can choose n large enough such that 
 $\|R (T-in)^{-1}\| < \epsilon $
. Then for any
$\|R (T-in)^{-1}\| < \epsilon $
. Then for any 
 $\psi \in  {\mathrm {Dom}}(T)$
, we have
$\psi \in  {\mathrm {Dom}}(T)$
, we have 
 $$\begin{align*}\|R\psi\| \leq \|R (T-in)^{-1}\| \, \|(T-in)\psi\| \leq \epsilon \|(T-in)\psi\| \leq \epsilon \|T\psi\| + \epsilon n \|\psi\| , \end{align*}$$
$$\begin{align*}\|R\psi\| \leq \|R (T-in)^{-1}\| \, \|(T-in)\psi\| \leq \epsilon \|(T-in)\psi\| \leq \epsilon \|T\psi\| + \epsilon n \|\psi\| , \end{align*}$$
where 
 $C_\epsilon := \epsilon n$
 is independent of
$C_\epsilon := \epsilon n$
 is independent of 
 $\psi $
.
$\psi $
.
Proposition A.7. Let T be a regular self-adjoint operator on E, and let R be a symmetric operator on E which is relatively T-compact. Then 
 $T+R$
 is also regular and self-adjoint on
$T+R$
 is also regular and self-adjoint on 
 $ {\mathrm {Dom}}(T+R)= {\mathrm {Dom}}(T)$
.
$ {\mathrm {Dom}}(T+R)= {\mathrm {Dom}}(T)$
.
Proof. By Proposition A.6, we have for any 
 $0<a<1$
 that
$0<a<1$
 that 
 $\| R\psi \| \leq a \|T\psi \| + C_a \|\psi \|$
 for all
$\| R\psi \| \leq a \|T\psi \| + C_a \|\psi \|$
 for all 
 $\psi \in  {\mathrm {Dom}}(T)$
. It then follows from the Kato-Rellich Theorem on Hilbert
$\psi \in  {\mathrm {Dom}}(T)$
. It then follows from the Kato-Rellich Theorem on Hilbert 
 $C^*$
-modules ([Reference Kaad and LeschKL12, Theorem 4.5]) that
$C^*$
-modules ([Reference Kaad and LeschKL12, Theorem 4.5]) that 
 $T+R$
 is also regular and self-adjoint with
$T+R$
 is also regular and self-adjoint with 
 $ {\mathrm {Dom}}(T+R)= {\mathrm {Dom}}(T)$
.
$ {\mathrm {Dom}}(T+R)= {\mathrm {Dom}}(T)$
.
 The following result generalises [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Proposition 3.4] to the context of regular operators on Hilbert 
 $C^*$
-modules.
$C^*$
-modules.
Proposition A.8. Let T be a regular self-adjoint operator on E, and let R be a symmetric operator on E which is relatively T-compact. Then 
 $F_{T+R} - F_T$
 is compact.
$F_{T+R} - F_T$
 is compact.
Proof. The proof is similar to the Hilbert space proof given in [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Proposition 3.4] but requires minor adaptations. For completeness, we include the details here.
- 
1. We first prove a special case: assume that R is compact and  $ {\mathrm {Ran}} R \subset  {\mathrm {Dom}} T$
. In this case, it suffices to show the compactness of $ {\mathrm {Ran}} R \subset  {\mathrm {Dom}} T$
. In this case, it suffices to show the compactness of $F_{T+R} - F_T - R\big (1+(T+R)^2\big )^{-\frac 12} = T\big (1+(T+R)^2\big )^{-\frac 12} - T\big (1+T^2\big )^{-\frac 12}$
. We note that $F_{T+R} - F_T - R\big (1+(T+R)^2\big )^{-\frac 12} = T\big (1+(T+R)^2\big )^{-\frac 12} - T\big (1+T^2\big )^{-\frac 12}$
. We note that $(T+R)^2-T^2 = TR+R(T+R)$
 is well-defined on $(T+R)^2-T^2 = TR+R(T+R)$
 is well-defined on $ {\mathrm {Dom}} T =  {\mathrm {Dom}} (T+R)$
. We can then use the integral formula $ {\mathrm {Dom}} T =  {\mathrm {Dom}} (T+R)$
. We can then use the integral formula $(1+T^2)^{-\frac 12} = \frac 1\pi \int _0^\infty \lambda ^{-\frac 12} (1+\lambda +T^2)^{-1} \, \mathrm {d}\lambda $
 (and similarly for $(1+T^2)^{-\frac 12} = \frac 1\pi \int _0^\infty \lambda ^{-\frac 12} (1+\lambda +T^2)^{-1} \, \mathrm {d}\lambda $
 (and similarly for $T+R$
) along with the resolvent identity to rewrite $T+R$
) along with the resolvent identity to rewrite $$ \begin{align*} &T\big(1+(T+R)^2\big)^{-\frac12} - T\big(1+T^2\big)^{-\frac12} \\ &\quad= \frac1\pi \int_0^\infty \lambda^{-\frac12} T \big(1+\lambda+T^2\big)^{-1} \big( T^2 - (T+R)^2 \big) \big( 1+\lambda+(T+R)^2 \big)^{-1} \, \mathrm{d}\lambda \\ &\quad= - \frac1\pi \int_0^\infty \lambda^{-\frac12} T \big(1+\lambda+T^2\big)^{-1} \big( TR + R(T+R) \big) \big( 1+\lambda+(T+R)^2 \big)^{-1} \, \mathrm{d}\lambda. \end{align*} $$ $$ \begin{align*} &T\big(1+(T+R)^2\big)^{-\frac12} - T\big(1+T^2\big)^{-\frac12} \\ &\quad= \frac1\pi \int_0^\infty \lambda^{-\frac12} T \big(1+\lambda+T^2\big)^{-1} \big( T^2 - (T+R)^2 \big) \big( 1+\lambda+(T+R)^2 \big)^{-1} \, \mathrm{d}\lambda \\ &\quad= - \frac1\pi \int_0^\infty \lambda^{-\frac12} T \big(1+\lambda+T^2\big)^{-1} \big( TR + R(T+R) \big) \big( 1+\lambda+(T+R)^2 \big)^{-1} \, \mathrm{d}\lambda. \end{align*} $$Observing that the integrand is compact and of order  $\mathcal {O}(\lambda ^{-\frac 32})$
, we see that the integral converges in norm to a compact operator, and we conclude that $\mathcal {O}(\lambda ^{-\frac 32})$
, we see that the integral converges in norm to a compact operator, and we conclude that $F_{T+R} - F_T$
 is compact. $F_{T+R} - F_T$
 is compact.
- 
2. We now prove the general case by reducing to the special case. For  $n\in \mathbb {N}$
, consider compactly supported continuous functions $n\in \mathbb {N}$
, consider compactly supported continuous functions $\phi _n \in C_c(\mathbb {R})$
 satisfying $\phi _n \in C_c(\mathbb {R})$
 satisfying $0 \leq \phi _n(x) \leq 1$
 for all $0 \leq \phi _n(x) \leq 1$
 for all $x\in \mathbb {R}$
, $x\in \mathbb {R}$
, $\phi _n(x) = 1$
 if $\phi _n(x) = 1$
 if $|x| \leq n$
, and $|x| \leq n$
, and $\phi _n(x) = 0$
 if $\phi _n(x) = 0$
 if $|x| \geq n+1$
. Using continuous functional calculus, we construct the operators $|x| \geq n+1$
. Using continuous functional calculus, we construct the operators $\phi _n(T) \in \mathcal {L}_A(E)$
, and we note that $\phi _n(T) \in \mathcal {L}_A(E)$
, and we note that $ {\mathrm {Ran}} \phi _n(T) \subset  {\mathrm {Dom}} T$
 (since $ {\mathrm {Ran}} \phi _n(T) \subset  {\mathrm {Dom}} T$
 (since $\phi _n$
 is compactly supported). We now consider the operators and we note that $\phi _n$
 is compactly supported). We now consider the operators and we note that $$\begin{align*}R_n := \phi_n(T) R \phi_n(T) = \underbrace{\phi_n(T)}_{\text{bounded}} \, \underbrace{R(T-i)^{-1}}_{\text{compact}} \; \underbrace{(T-i)\phi_n(T)}_{\text{bounded}} , \end{align*}$$ $$\begin{align*}R_n := \phi_n(T) R \phi_n(T) = \underbrace{\phi_n(T)}_{\text{bounded}} \, \underbrace{R(T-i)^{-1}}_{\text{compact}} \; \underbrace{(T-i)\phi_n(T)}_{\text{bounded}} , \end{align*}$$ $R_n$
 is compact with $R_n$
 is compact with $ {\mathrm {Ran}} R_n \subset  {\mathrm {Dom}} T$
. Thus, the special case applies to $ {\mathrm {Ran}} R_n \subset  {\mathrm {Dom}} T$
. Thus, the special case applies to $R_n$
. $R_n$
.As  $n\to \infty $
, the operators $n\to \infty $
, the operators $\phi _n(T)$
 converge strongly (hence, by self-adjointness, $\phi _n(T)$
 converge strongly (hence, by self-adjointness, $*$
-strongly) to the identity (see, for example, [Reference Kaad and LeschKL12, Lemma 7.2]). Since $*$
-strongly) to the identity (see, for example, [Reference Kaad and LeschKL12, Lemma 7.2]). Since $R(T-i)^{-1}$
 is compact, it follows from Lemma A.1 that $R(T-i)^{-1}$
 is compact, it follows from Lemma A.1 that $R_n(T-i)^{-1}$
 converges in norm to $R_n(T-i)^{-1}$
 converges in norm to $R(T-i)^{-1}$
. From Proposition A.4, we therefore obtain that $R(T-i)^{-1}$
. From Proposition A.4, we therefore obtain that $F_{T+R_n}$
 converges in norm to $F_{T+R_n}$
 converges in norm to $F_{T+R}$
. Since $F_{T+R}$
. Since $F_{T+R_n}-F_T$
 is compact by the special case, we conclude that also $F_{T+R_n}-F_T$
 is compact by the special case, we conclude that also $F_{T+R}-F_T$
 is compact. $F_{T+R}-F_T$
 is compact.
Proposition A.9. Let T be a regular self-adjoint operator on E, and let R be a symmetric operator on E which is relatively T-compact. Let 
 $f\in C(\mathbb {R})$
 be a continuous function for which the limits
$f\in C(\mathbb {R})$
 be a continuous function for which the limits 
 $\lim _{x\to \pm \infty }f(x)$
 exist. Then
$\lim _{x\to \pm \infty }f(x)$
 exist. Then 
 $f(T+R)-f(T)$
 is compact.
$f(T+R)-f(T)$
 is compact.
Proof. The statement clearly holds for constant functions, and by Proposition A.8 also for the ‘bounded transform function’ 
 $b\in C(\mathbb {R})$
 given by
$b\in C(\mathbb {R})$
 given by 
 $b(x) := x(1+x^2)^{-\frac 12}$
. It remains to prove the statement for functions
$b(x) := x(1+x^2)^{-\frac 12}$
. It remains to prove the statement for functions 
 $f\in C_0(\mathbb {R})$
 vanishing at infinity, and for this, it suffices to consider
$f\in C_0(\mathbb {R})$
 vanishing at infinity, and for this, it suffices to consider 
 $f(x) = (x\pm i)^{-1}$
. But for the latter, the statement follows immediately from the resolvent identity and compactness of
$f(x) = (x\pm i)^{-1}$
. But for the latter, the statement follows immediately from the resolvent identity and compactness of 
 $R(T\pm i)^{-1}$
:
$R(T\pm i)^{-1}$
: 
 $$\begin{align*}(T+R\pm i)^{-1} - (T\pm i)^{-1} = - (T+R\pm i)^{-1} R (T\pm i)^{-1}.\\[-41pt] \end{align*}$$
$$\begin{align*}(T+R\pm i)^{-1} - (T\pm i)^{-1} = - (T+R\pm i)^{-1} R (T\pm i)^{-1}.\\[-41pt] \end{align*}$$
 The following result partly generalises [Reference Lesch, Booss-Bavnbek, Grubb and WojciechowskiLes05, Corollary 3.5] to the context of regular operators on Hilbert 
 $C^*$
-modules, under somewhat stronger assumptions.
$C^*$
-modules, under somewhat stronger assumptions.
Corollary A.10. Let T be a regular self-adjoint operator on E, and let R be a symmetric operator on E which is relatively T-compact. Assume that T and 
 $T+R$
 are both invertible. Then the difference of positive spectral projections
$T+R$
 are both invertible. Then the difference of positive spectral projections 
 $P_+(T+R) - P_+(T)$
 is compact.
$P_+(T+R) - P_+(T)$
 is compact.
Proof. Since T and 
 $T+R$
 are invertible, there exists an
$T+R$
 are invertible, there exists an 
 $\epsilon>0$
 such that
$\epsilon>0$
 such that 
 $(-\epsilon ,\epsilon )$
 does not intersect with the union
$(-\epsilon ,\epsilon )$
 does not intersect with the union 
 $ {\mathrm {spec}}(T) \cup  {\mathrm {spec}}(T+R)$
 of the spectra of T and
$ {\mathrm {spec}}(T) \cup  {\mathrm {spec}}(T+R)$
 of the spectra of T and 
 $T+R$
. Then the positive spectral projections can be defined via continuous functional calculus (i.e., we can take
$T+R$
. Then the positive spectral projections can be defined via continuous functional calculus (i.e., we can take 
 $\chi \in C(\mathbb {R})$
 with
$\chi \in C(\mathbb {R})$
 with 
 $\chi |_{(-\infty ,-\epsilon ]} \equiv 0$
 and
$\chi |_{(-\infty ,-\epsilon ]} \equiv 0$
 and 
 $\chi |_{[\epsilon ,\infty )} \equiv 1$
 and see that
$\chi |_{[\epsilon ,\infty )} \equiv 1$
 and see that 
 $P_+(T) = \chi (T)$
 and
$P_+(T) = \chi (T)$
 and 
 $P_+(T+R) = \chi (T+R)$
). The statement then follows from Proposition A.9.
$P_+(T+R) = \chi (T+R)$
). The statement then follows from Proposition A.9.
 A regular operator T on E is called Fredholm if there exists a parametrix Q such that (the closure of) 
 $QT - 1$
 and
$QT - 1$
 and 
 $TQ - 1$
 are compact operators on E. We recall that an odd resp. even regular self-adjoint Fredholm operator T on a possibly
$TQ - 1$
 are compact operators on E. We recall that an odd resp. even regular self-adjoint Fredholm operator T on a possibly 
 $\mathbb {Z}_2$
-graded Hilbert A-module E yields a well-defined class
$\mathbb {Z}_2$
-graded Hilbert A-module E yields a well-defined class 
 $[T]$
 in
$[T]$
 in  resp.
 resp.  ; for details of the construction, we refer to [Reference van den DungenDun19, §2.2].
; for details of the construction, we refer to [Reference van den DungenDun19, §2.2].
Our last result shows that this K-theory class is stable under relatively compact perturbations.
Proposition A.11. Let T be a regular self-adjoint Fredholm operator on E, and let R be a symmetric operator on E which is relatively T-compact. Then
- 
1.  $T+R$
 is also regular, selfadjoint and Fredholm, and any parametrix for T is also a parametrix for $T+R$
 is also regular, selfadjoint and Fredholm, and any parametrix for T is also a parametrix for $T+R$
. $T+R$
.
- 
2.  (where (where $p=0$
 if $p=0$
 if $R,T$
 are odd, and $R,T$
 are odd, and $p=1$
 otherwise). $p=1$
 otherwise).
Proof.
- 
1. We first note that  $T+R$
 is also regular and selfadjoint by Proposition A.7. If $T+R$
 is also regular and selfadjoint by Proposition A.7. If $Q \in \mathcal {L}_A(E)$
 is a parametrix for T, then it is also a parametrix for $Q \in \mathcal {L}_A(E)$
 is a parametrix for T, then it is also a parametrix for $T+R$
 since is compact. Similarly, also $T+R$
 since is compact. Similarly, also $$\begin{align*}(T+R)Q-1 = (TQ-1) + R(T-i)^{-1} (T-i)Q \end{align*}$$ $$\begin{align*}(T+R)Q-1 = (TQ-1) + R(T-i)^{-1} (T-i)Q \end{align*}$$ $Q(T+R)-1$
 is compact. $Q(T+R)-1$
 is compact.
- 
2. Let  $T_t := T + tR$
, and consider the operator $T_t := T + tR$
, and consider the operator $T_\bullet = \{T_t\}_{t\in [0,1]}$
 on the Hilbert $T_\bullet = \{T_t\}_{t\in [0,1]}$
 on the Hilbert $C([0,1],A)$
-module $C([0,1],A)$
-module $C([0,1],E)$
. Since $C([0,1],E)$
. Since $t \mapsto T_t\psi $
 is continuous for each $t \mapsto T_t\psi $
 is continuous for each $\psi \in  {\mathrm {Dom}}(T)$
, we know that $\psi \in  {\mathrm {Dom}}(T)$
, we know that $T_\bullet $
 is regular and self-adjoint ([Reference van den Dungen and MeslandDM20, Lemma 1.15]). $T_\bullet $
 is regular and self-adjoint ([Reference van den Dungen and MeslandDM20, Lemma 1.15]).If  $Q \in \mathcal {L}_A(E)$
 is a parametrix for T, then by 1, it is also a parametrix for $Q \in \mathcal {L}_A(E)$
 is a parametrix for T, then by 1, it is also a parametrix for $T_t$
 for each $T_t$
 for each $t\in [0,1]$
 since $t\in [0,1]$
 since $tR$
 is relatively T-compact. Consequently, noting that $tR$
 is relatively T-compact. Consequently, noting that $t \mapsto tRQ$
 is norm-continuous, the constant family $t \mapsto tRQ$
 is norm-continuous, the constant family $Q_\bullet = \{Q\}_{t\in [0,1]}$
 is a parametrix for $Q_\bullet = \{Q\}_{t\in [0,1]}$
 is a parametrix for $T_\bullet $
. Hence, $T_\bullet $
. Hence, $T_\bullet $
 is a regular self-adjoint Fredholm operator on the Hilbert $T_\bullet $
 is a regular self-adjoint Fredholm operator on the Hilbert $C([0,1],A)$
-module $C([0,1],A)$
-module $C([0,1],E)$
 and therefore a homotopy between T and $C([0,1],E)$
 and therefore a homotopy between T and $T+R$
 (in the sense of [Reference van den DungenDun19, Definition 2.13]). Thus, $T+R$
 (in the sense of [Reference van den DungenDun19, Definition 2.13]). Thus, $[T]=[T+R]$
 by [Reference van den DungenDun19, Proposition 2.14]. $[T]=[T+R]$
 by [Reference van den DungenDun19, Proposition 2.14].
 In the 
 $\mathbb {Z}_2$
-graded case, where we have a decomposition
$\mathbb {Z}_2$
-graded case, where we have a decomposition 
 $E = E_+ \oplus E_-$
 and T is odd (i.e., maps
$E = E_+ \oplus E_-$
 and T is odd (i.e., maps 
 $E_\pm \to E_\mp $
), the class
$E_\pm \to E_\mp $
), the class  corresponds to the
 corresponds to the 
 $K_0(A)$
-valued index of
$K_0(A)$
-valued index of 
 $T_+ := T|_{E_+} \colon E_+ \to E_-$
 under the isomorphism
$T_+ := T|_{E_+} \colon E_+ \to E_-$
 under the isomorphism  . Thus, in this case, the above result translates into the stability of the
. Thus, in this case, the above result translates into the stability of the 
 $K_0(A)$
-valued index under relatively compact perturbations.
$K_0(A)$
-valued index under relatively compact perturbations.
Acknowledgements
The author thanks Matthias Lesch for inspiration and interesting discussions. The author also thanks the referee for suggestions which helped improve the exposition of the paper.
Competing interest
The author has no competing interest to declare.
Financial support
The author acknowledges financial support from the Hausdorff Center for Mathematics in Bonn, funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1 – 390685813.
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 



 
 
 
 
 

 
 
 
 
 
 
 
 


 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 .
. 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 (where
 (where  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
