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Accepted manuscript

Does pharmacogenetic testing optimise antidepressant effectiveness in major depressive disorder? Data from a double blind randomized controlled trial in a real-world setting

Published online by Cambridge University Press:  24 November 2025

Alessandra Minelli Open the ORCID record for Alessandra Minelli [Opens in a new window] ,
Stefano Barlati Open the ORCID record for Stefano Barlati [Opens in a new window] ,
Stefano Bignotti ,
Valentina Menesello Open the ORCID record for Valentina Menesello [Opens in a new window] ,
Gabriele Nibbio ,
Giulia Perusi ,
Alessia Muscarella ,
Lisa Buson Open the ORCID record for Lisa Buson [Opens in a new window] ,
Ughetta Bosco Umbertino Open the ORCID record for Ughetta Bosco Umbertino [Opens in a new window]  and
Paolo Martini Open the ORCID record for Paolo Martini [Opens in a new window]
...Show all authors
Alessandra Minelli
Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Stefano Barlati*
Affiliation:
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Stefano Bignotti
Affiliation:
Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Valentina Menesello
Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
Gabriele Nibbio
Affiliation:
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Giulia Perusi
Affiliation:
Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Alessia Muscarella
Affiliation:
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy
Lisa Buson
Affiliation:
Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Ughetta Bosco Umbertino
Affiliation:
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy
Paolo Martini
Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
Rosana Carvalho Silva
Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
Edoardo Spina
Affiliation:
Clinical and Experimental Medicine, University of Messina, Messina, Italy
Giovanni Batista Tura
Affiliation:
Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Antonio Vita
Affiliation:
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Massimo Gennarelli
Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
*
*Corresponding author: Stefano Barlati, MD - Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa, 11 - 25123 Brescia, Italy; Tel.: +39 030 3995233; E-mail address: stefano.barlati@unibs.it

Abstract

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Keywords

pharmacogenetic testinggeneticsdepressionantidepressant treatmentrandomized controlled trial

Information

Type
Research Article
Information
European Psychiatry , Accepted manuscript , pp. 1 - 25
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of European Psychiatric Association

Footnotes

a

Members of PANDORA Study Group: Alessandra Minelli, Massimo Gennarelli, Valentina Menesello (Genetic Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli of Brescia; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy); Beatrice Lana, Chiara Galbiati, Edoardo Giacopuzzi, Erika Vitali, Giulia Perusi, Lisa Buson, Monica Scaglia, Vincenzo Dattilo (Genetic Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli of Brescia); Antonio Vita, Stefano Barlati (Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy), Alessia Muscarella, Antonio Baglioni, Gabriele Nibbio, Irene Calzavara Pinton, Lorenzo Bertoni, Nicola Necchini, Stefano Paolini, Ughetta Bosco Umbertino (Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia); Anna Magistrali, Chiara Magri, Mattia Meattini, Rosana Carvalho Silva, Paolo Martini (Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy); Chiara Cobelli, Giovanni Battista Tura, Stefano Bignotti (Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy); Edoardo Spina (Clinical and Experimental Medicine, University of Messina, Messina, Italy).

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