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The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood

Published online by Cambridge University Press:  23 July 2013

Elizabeth P. Hayden ,
Thomas M. Olino ,
Sara J. Bufferd ,
Anna Miller ,
Lea R. Dougherty ,
Haroon I. Sheikh ,
Shiva M. Singh  and
Daniel N. Klein
Elizabeth P. Hayden*
Affiliation:
University of Western Ontario
Thomas M. Olino
Affiliation:
Stony Brook University
Sara J. Bufferd
Affiliation:
Stony Brook University
Anna Miller
Affiliation:
Stony Brook University
Lea R. Dougherty
Affiliation:
Stony Brook University
Haroon I. Sheikh
Affiliation:
University of Western Ontario
Shiva M. Singh
Affiliation:
University of Western Ontario
Daniel N. Klein
Affiliation:
Stony Brook University
*
Address correspondence and reprint requests to: Elizabeth P. Hayden, University of Western Ontario, Department of Psychology, London, ON N6A 3K7, Canada; E-mail: ehayden@uwo.ca.
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Abstract

Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children's sensitivity to contextual factors.

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Regular Articles
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Development and Psychopathology , Volume 25 , Issue 3 , August 2013 , pp. 587 - 598
Copyright
Copyright © Cambridge University Press 2013 

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