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Continuity and cascade in offspring of bipolar parents: A longitudinal study of externalizing, internalizing, and thought problems

Published online by Cambridge University Press:  01 October 2010

Bonnie Klimes-Dougan ,
Jeffrey D. Long ,
Chih-Yuan Steven Lee ,
Donna S. Ronsaville ,
Philip W. Gold  and
Pedro E. Martinez
Bonnie Klimes-Dougan*
Affiliation:
University of Minnesota
Jeffrey D. Long
Affiliation:
University of Minnesota
Chih-Yuan Steven Lee
Affiliation:
University of Minnesota
Donna S. Ronsaville
Affiliation:
National Institute of Mental Health
Philip W. Gold
Affiliation:
National Institute of Mental Health
Pedro E. Martinez
Affiliation:
National Institute of Mental Health
*
Address correspondence and reprint requests to: Bonnie Klimes-Dougan, Department of Psychology, University of Minnesota, N-414 Elliot Hall, 75 West River Road, Minneapolis, MN 55455; E-mail: klimes@umn.edu.
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Abstract

There is growing evidence that many offspring of bipolar parents will develop moderate to severe forms of psychopathology during childhood and adolescence. The purpose of this study was to apply growth curve models to evaluate developmental progression with regard to continuity and cascades representative within the context of a family risk study of bipolar disorder (BD). Repeated assessments of externalizing, internalizing, and thought problems, spanning more than a decade, were examined in a total of 94 offspring of parents with BD (O-BD), major depressive disorder (O-UNI), or no significant psychiatric or medical problems (O-WELL). Continuity was defined by the growth curve of the O-WELL group who exhibited low levels of problems from early childhood through late adolescence. Discontinuity, as evidenced by greater complexity of growth curves relative to the O-WELL group, was exhibited in the at- risk offspring groups for internalizing problems. Different patterns of developmental cascades were supported for the at-risk group with O-UNI showing a robust cascade from self-regulatory deficits (externalizing problems) to internalizing problems. There was also support for a cascade from self-regulatory deficits to thought problems across the entire group (with some support that this pattern was accounted for primarily by O-BD). This study not only serves to advance our understanding of the risks associated with a family history of BD, but also provides a novel approach to examining developmental cascades.

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Type
Regular Articles
Information
Development and Psychopathology , Volume 22 , Issue 4: Developmental Cascades: Part 2 , November 2010 , pp. 849 - 866
Copyright
Copyright © Cambridge University Press 2010

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References

Achenbach, T. M. (1991). Manual for the Child Behavior Checklist/4–18 and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry.Google Scholar
Akaike, H. (1985). Prediction and entropy. In Atkinson, A. C. & Fienberg, S. E. (Eds.), A celebration of statistics (pp. 1–24). New York: Springer.Google Scholar
Akiskal, H., Downs, J., Jordon, P., & Watson, S. (1985). Affective disorders in referred children and younger siblings of manic depressives: Mode of onset and prospective course. Archives of General Psychiatry, 42, 996–1003.CrossRefGoogle ScholarPubMed
Alon, U. (2007). An introduction to systems biology: Design principles of biological circuits. New York: Chapman & Hall/CRC Press.Google Scholar
Anderson, C. A., & Hammen, C. L. (1993). Psychosocial outcomes of children of unipolar depressed, bipolar, medically ill, and normal women: A longitudinal study. Journal of Consulting and Clinical Psychology, 61, 448–454.CrossRefGoogle ScholarPubMed
Anderson, D. R. (2008). Model based inference in the life sciences: A primer on evidence. New York: Springer.CrossRefGoogle Scholar
Angst, J. (2002). Historical aspects of the dichotomy between manic–depressive disorders and schizophrenia. Schizophrenia Research, 57, 5–13.CrossRefGoogle ScholarPubMed
Bates, D. (2005). Fitting linear mixed models in R. R News, 5, 27–30.Google Scholar
Berrettini, W. (2000). Are schizophrenia and bipolar disorders related? A review of family and molecular studies. Biological Psychiatry, 48, 531–538.CrossRefGoogle ScholarPubMed
Birmaher, B., Axelson, D., Monk, K., Kalas, C., Goldstein, B., Hickey, M. B., et al. (2009). Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder. Archives of General Psychiatry, 66, 287–296.CrossRefGoogle ScholarPubMed
Bramon, E., & Sham, P. (2001). The common genetic liability between schizophrenia and bipolar disorder: A review. Current Psychiatry Reports, 3, 333–337.CrossRefGoogle ScholarPubMed
Burnham, K. P., & Anderson, D. R. (2004). Multimodel inference: Understanding AIC and BIC in model selection. Sociological Methods and Research, 33, 261–304.CrossRefGoogle Scholar
Carlson, G. A., & Weintraub, S. (1993). Childhood behavior problems and bipolar disorder—Relationship or coincidence? Journal of Affective Disorder, 28, 143–153.CrossRefGoogle ScholarPubMed
Caspi, A., & Roberts, B. W. (1999). Personality change and continuity across the life course. In Pervin, L. A. & John, O. P. (Eds.), Handbook of personality theory and research (Vol. 2, pp. 300–326). New York: Guilford Press.Google Scholar
Caukins, S. D., & Howse, R. B. (2004). Individual differences in self-regulation: Implications for childhood. In Philippot, P. & Feldman, R. S. (Eds.), The regulation of emotion. Mahwah, NJ: Erlbaum.Google Scholar
Chang, K., Steiner, H., & Ketter, T. (2003). Studies of offspring of parents with bipolar disorder. American Journal of Medical Genetics, 123C, 26–35.Google ScholarPubMed
Chatfield, C. (1995). Model uncertainty, data mining and statistical inference. Journal of the Royal Statistical Society, 158A, 419–466.CrossRefGoogle Scholar
Cicchetti, D., & Rogosch, F. A. (1996). Equafinality and multifinality in developmental psychopathology. Developmental Psychopathology, 8, 597–600.CrossRefGoogle Scholar
Cicchetti, D., & Rogosch, F. A. (2002). A developmental psychopathology perspective on adolescence. Journal of Consulting and Clinical Psychology, 70, 6–20.CrossRefGoogle ScholarPubMed
Cleveland, W. S., Grosse, E., & Shyu, W. M. (1992). Local regression models. In Chambers, J. M. & Hastie, T. J. (Eds.), Statistical models in S. Pacific Grove, CA: Wadsworth & Brooks/Cole.Google Scholar
Cole, D. A., & Maxwell, S. E. (2003). Testing meditational models with longitudinal data: Questions and tips in the use of structural equation modeling. Journal of Abnormal Psychology, 112, 558–577.CrossRefGoogle Scholar
Conners, C. K., Himmelhock, J., Goyette, C. H., Ulrich, R., & Neil, J. F. (1979). Children of parents with affective illness. Journal of the American Academy of Child & Adolescent Psychiatry, 18, 600–607.Google ScholarPubMed
Craddock, N., & Jones, I. (2001). Molecular genetics of bipolar disorder. British Journal of Psychiatry, 178, 128–133.CrossRefGoogle ScholarPubMed
DelBello, M. P., & Geller, B. (2001). Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disorder, 3, 325–334.CrossRefGoogle ScholarPubMed
Dienes, K. A., Chang, K. D., Blasey, C. M., Adleman, N. E., & Steiner, H. (2002). Characterization of children of bipolar parents by parent report CBCL. Journal of Psychiatric Research, 36, 337–345.CrossRefGoogle ScholarPubMed
Downey, G., & Coyne, J. C. (1990). Children of depressed parents: An integrative review. Psychological Bulletin 108, 50–76.CrossRefGoogle ScholarPubMed
Duffy, A., Alda, M., Crawford, L., Milin, R., & Grof, P. (2007). The early manifestations of bipolar disorder: A longitudinal prospective study of the offspring of bipolar parents. Bipolar Disorder, 9, 828–838.CrossRefGoogle ScholarPubMed
Duffy, A., Alda, M., Kutcher, S., Cavazzoni, P., Robertson, C., Grof, E., et al. (2002). A prospective study of offspring of bipolar parents responsive and nonresponsive to lithium treatment. Journal of Clinical Psychiatry, 63, 1171–1178.CrossRefGoogle ScholarPubMed
Dunayevich, E., & Keck, P. (2000). Prevalence and description of psychotic features in bipolar mania. Current Psychiatry Reports, 2, 286–290.CrossRefGoogle ScholarPubMed
Endicott, J., Spitzer, R. L., Fleiss, J. L., & Cohen, J. (1976). The Global Assessment Scale: A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766–771.CrossRefGoogle Scholar
Farchione, T. R., Birmaher, B., Axelson, D., Kalas, C., Monk, K., Ehmann, M., et al. (2007). Aggression, hostility, and irritability in children at risk for bipolar disorder. Bipolar Disorders, 9, 496–503.CrossRefGoogle ScholarPubMed
Fendrich, M., Warner, V., & Weissman, M. M. (1990). Family risk factors, parental depression, and psychopathology in offspring. Developmental Psychology, 26, 40–50.CrossRefGoogle Scholar
Garber, J., Clarke, G. N., Weersing, U. R., Beardslee, W. R., Brent, D. A., Galdstonem, T. R. G., et al. (2009). Prevention of depression in at risk adolescents: A randomized control trial. Journal of the American Medical Association, 301, 2215–2224.CrossRefGoogle Scholar
Gershon, E. S., Hamovit, J., Guroff, J. J., Dibble, E., Leckman, J. F., Sceery, W., et al. (1982). A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry, 39, 1157–1167.CrossRefGoogle ScholarPubMed
Giles, L. L., DelBello, M. P., Stanford, K. E., & Strakowski, S. M. (2007). Child Behavior Checklist profiles of children and adolescents at high risk for developing bipolar disorder. Child Psychiatry and Human Development, 38, 47–55.CrossRefGoogle ScholarPubMed
Grigoroiu-Serbanescu, M., Christodorescu, D., Totescu, A., & Jipescu, I. (1991). Depressive disorders and depressive personality traits in offspring aged 10–17 of bipolar and normal parents. Journal of Youth and Adolescence, 20, 135–148.CrossRefGoogle ScholarPubMed
Grizzle, J. E., Starmer, C. F., & Koch, G. G. (1969). Analysis of categorical data by linear models. Biometrics, 25, 489–504.CrossRefGoogle ScholarPubMed
Hammen, C., Burge, D., Burney, E., & Adrian, C. (1990). Longitudinal study of diagnosis in children of women with unipolar and bipolar affective disorder. Archives of General Psychiatry, 47, 1112–1117.CrossRefGoogle ScholarPubMed
Hammen, C., Gordon, D., Burge, D., Adrian, C., Jaenicke, C., & Hiroto, D. (1987). Maternal affective disorders, illness, and stress: Risk for children's psychopathology. American Journal of Psychiatry, 144, 736–741.Google ScholarPubMed
Henin, A., Biederman, J., Mick, E., Sachs, G. S., Hirshfeld-Becker, D. R., Siegel, R. S., et al. , (2005). Psychopathology in the offspring of parents with bipolar disorder: A controlled study. Biological Psychiatry, 58, 554–561.CrossRefGoogle ScholarPubMed
Hillegers, M. H. J., Reichart, C. G., Wals, M., Verhulst, F. C., Ormel, J., & Nolen, W. A. (2005). Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents. Bipolar Disorders, 7, 344–350.CrossRefGoogle ScholarPubMed
Hirschfeld-Becker, D., Biederman, J., Henin, A., Faraone, S. V., Dowd, S. T., De Petrillo, L. A., et al. (2006). Psychopathology in the young offspring of parents with bipolar disorder: A controlled pilot study. Psychiatry Research, 145, 155–167.CrossRefGoogle Scholar
Hollingshead, A. B. (1975). Four-Factor Index of Social Status. New Haven, CT: Yale University, Sociology Department.Google Scholar
Hurvich, C. M., & Tsai, C.-L. (1989). Regression and time series model selection in small samples. Biometrika, 76, 297–307.CrossRefGoogle Scholar
Kashani, J. H., Burk, J. P., Horwitz, B., & Reid, J. C. (1985). Differential effect of subtype of parental major affective disorder on children. Psychiatry Research, 15, 195–204.CrossRefGoogle ScholarPubMed
Klein, D. N., Depue, R. A., & Krauss, S. P. (1986). Social adjustment in the offspring of parents with bipolar affective disorder. Journal of Psychopathology and Behavioral Assessment, 8, 355–365.CrossRefGoogle Scholar
Klimes-Dougan, B. (1998). Screening for suicide in children and adolescents: Methodological considerations. Journal of Adolescence, 21, 435–444.CrossRefGoogle ScholarPubMed
Klimes-Dougan, B., Free, K., Ronasaville, D., Stilwell, J., Welsh, C. J., & Radke-Yarrow, M. (1999). Suicidal ideation and attempts in children of depressed and well mothers: A longitudinal study. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 651–659.CrossRefGoogle Scholar
Klimes-Dougan, B., Lee, C.-Y. S., Ronsaville, D., & Martinez, P. (2008). Suicidal risk in young adult offspring of mothers with bipolar or major depressive disorder: A longitudinal family risk study. Journal of Clinical Psychology, 64, 1–11.CrossRefGoogle ScholarPubMed
Kopp, C. (1982). Antecedents of self-regulation: A developmental perspective. Developmental Psychology, 18, 199–214.CrossRefGoogle Scholar
Kornberg, J. R., Brown, J. L., Sadovnick, A. D., Remick, R. A., Keck, P. E. Jr., McElroy, S. L., et al. , (2000). Evaluating the parent of origin effect in bipolar affective disorder. Is a more penetrant subtype transmitted paternally? Journal of Affective Disorders, 59, 183–192.CrossRefGoogle ScholarPubMed
Kraepelin, E. (1906). Uber Sprachstorungen im Traume. Leizpig: Engelmann.Google Scholar
Lapalme, M., Hodgins, S., & LaRoche, C. (1997). Children of parents with bipolar disorder: A metaanalysis of risk of mental disorders. Canadian Journal of Psychiatry, 42, 623–631.CrossRefGoogle Scholar
LaRoche, C., Sheiner, R., Lester, E., Benierakis, C., Marrache, M., Engelsmann, F., et al. (1987). Children of parents with manic depressive illness: A follow-up study. Canadian Journal of Psychiatry, 32, 563–569.CrossRefGoogle ScholarPubMed
Laursen, T. M., Agerbo, E., & Pedersen, C. B. (2009). Bipolar disorder, schizoaffective disorder, and schizophrenia overlap: A new comorbidity index. Journal of Clinical Psychiatry, 70, 1432–1439.CrossRefGoogle ScholarPubMed
Lazaro, L., Castro-Fornieles, J., de la Fuente, J. E., Baeza, I., Morer, A., & Pamias, M. (2007). Differences between prepubertal- versus adolescent- onset bipolar disorder in a Spanish clinical sample. European Child and Adolescent Psychiatry, 16, 510–516.CrossRefGoogle Scholar
Long, J. D., Harring, J. H., Brekke, J. S., Test, M. A., & Greenberg, J. (2007). Longitudinal construct validity of brief symptom inventory subscales in schizophrenia. Psychological Assessment, 19, 298–308.CrossRefGoogle ScholarPubMed
Long, J. D., Loeber, R., & Farrington, D. (2009). Marginal and random intercepts models for longitudinal binary data with examples from criminology. Multivariate Behavioral Research, 44, 1–31.CrossRefGoogle ScholarPubMed
Masten, A. S., & Curtis, W. J. (2000). Integrating competence and psychopathology: Pathways toward a comprehensive science of adaptation in development. Development and Psychopathology, 12, 529–550.CrossRefGoogle Scholar
Masten, A. S., Long, J. D., Kuo, S. I., McCormick, C. M., & Desjardins, C. D. (2009). Developmental models of strategic intervention. European Journal of Developmental Science, 3, 282–291.Google Scholar
Masten, A. S., Roisman, G. I., Long, J. D., Burt, K. B., Obradovic, J., Riley, J. R., et al. (2005). Developmental cascades: Linking academic achievement and externalizing and internalizing symptoms over 20 years. Developmental Psychopathology, 41, 733–746.Google ScholarPubMed
Maziade, M., Gingras, N., Rouleau, N., Poulin, S., Jomphe, V., Paradis, M.-E., et al. (2008). Clinical diagnosis in young offspring from eastern Quebec multigenerational families densely affected by schizophrenia or bipolar disorder. Acta Psychiatrica Scandinavica, 117, 118–126.CrossRefGoogle ScholarPubMed
Meyer, S. E., & Carlson, G. A. (2003). Bipolar disorder in youth: An update. Current Psychosis and Therapeutics Reports, 1, 79–84.CrossRefGoogle Scholar
Meyer, S. E., Carlson, G. A., Wiggs, E. A., Martinez, P. E., Ronsaville, D. S., Klimes-Dougan, B., et al. (2004). A prospective study of the association among impaired executive functioning, childhood attentional problems, and early onset bipolar disorder. Development and Psychopathology, 16, 461–476.CrossRefGoogle Scholar
Meyer, S. E., Carlson, G. A., Wiggs, E. A., Ronsaville, D. S., Martinez, P. E., Klimes-Dougan, B., et al. (2006). A prospective high-risk study of the association among maternal negativity, apparent frontal lobe dysfunction, and the development of bipolar disorder. Development and Psychopathology, 18, 573–589.CrossRefGoogle ScholarPubMed
Niemi, L. T., Suvisaari, J. M., Haukka, J. K., Wrede, G., & Lonnqvist, J. K. (2004). Cumulative incidence of mental disorders among offspring of mothers with psychotic disorder. British Journal of Psychiatry, 185, 11–17.CrossRefGoogle ScholarPubMed
Petty, C. R., Rosenbaum, J. F., Hirshfeld-Becker, D. R., Henin, A., Hubley, S., LaCasse, S., et al. , (2008). The Child Behavior Checklist broad-band scales predict subsequent psychopathology: A 5-year follow-up. Anxiety Disorders, 22, 523–539.CrossRefGoogle ScholarPubMed
Radke-Yarrow, M., & Klimes-Dougan, B. (1997). Children of depressed mothers: A developmental and interactional perspective. In Luthar, S., Burack, J., Cicchetti, D., & Weisz, J. (Eds.), Developmental psychopathology: Perspectives on adjustment, risk, and disorder. New York: Cambridge University Press.Google Scholar
Radke-Yarrow, M., & Klimes-Dougan, B. (2002). Parental depression and offspring disorders: A developmental perspective. In Goodman, S. H. & Gotlib, I. H. (Eds.), Children of depressed parents: Mechanisms of risk and implications for treatment. Washington, DC: American Psychological Association.Google Scholar
Radke-Yarrow, M., Martinez, P., Mayfield, A., & Ronsaville, D. (1998). Children of depressed mothers: From early childhood to maturity. Cambridge: Cambridge University Press.Google Scholar
Radke-Yarrow, M., Nottelmann, E., Martinez, P., Fox, M., & Belmont, B. (1992). Young children of affectively ill parents: A longitudinal study of psychosocial development. Journal of the American Academy of Child & Adolescent Psychiatry 31, 68–77.CrossRefGoogle ScholarPubMed
Reichart, C. G., van der Ende, J., Wals, M., Hillegers, M. H. J., Nolen, W. A., Ormel, J., et al. (2007). Social functioning of bipolar offspring. Journal of Affective Disorders, 98, 207–213.CrossRefGoogle ScholarPubMed
Richters, J. E. (1992). Depressed mothers as informants about their children: A critical review of the evidence for distortion. Psychological Bulletin, 112, 485–499.CrossRefGoogle ScholarPubMed
Rutter, M., & Soroufe, L. A. (2000). Developmental psychopathology: Concepts and challenges. Developmental Psychopathology, 12, 265–296.CrossRefGoogle ScholarPubMed
Schulenberg, J. E., Maggs, J. L., & O'Malley, P. M. (2003). How and why the understanding of developmental continuity and discontinuity is important: The sample case of long-term consequences of adolescent substance use. In Mortimer, J. T. & Shanahan, M. J. (Eds.), Handbook of the life course (pp. 413–436). New York: Plenum Press.CrossRefGoogle Scholar
Smoller, J. W., & Finn, C. T. (2003). Family, twin, and adoption studies of bipolar disorder. American Journal of Medical Genetics, 123C, 48.Google ScholarPubMed
Spitzer, R. L., & Endicott, J. (1977). The Schedule for Affective Disorders and Schizophrenia: Lifetime version. New York: New York State Psychiatric Institute, Biometrics Research.Google Scholar
Spitzer, R. L., Endicott, J., & Robins, E. (1978). Research diagnostic criteria, rationale and reliability. Archives of General Psychiatry, 35, 773–782.CrossRefGoogle ScholarPubMed
Tarullo, L. B., Richardson, D. T., Radke-Yarrow, M., & Martinez, P. E. (1995). Multiple sources in child diagnosis: Parent–child concordance in affectively ill and well families. Journal of Clinical Child Psychology, 24, 173–183.CrossRefGoogle Scholar
Taylor, L., Faraone, S. V., & Tsuang, M. (2002). Family, twin and adoption studies of bipolar disease. Current Psychiatry Reports, 4, 130–133.CrossRefGoogle ScholarPubMed
Taylor, M. A., Berenbaum, S. A., Jumpula, V. C., & Cloninger, C. R. (1993). Are schizophrenia and affective disorder related? Preliminary data from a family study. American Journal of Psychiatry, 150, 278–285.Google ScholarPubMed
Thompson, R. A. (1984). Emotion regulation: A theme in search of definition. Monographs of the Society for Research in Child Development, 59, 25–52.CrossRefGoogle Scholar
Valles, V., Van Os, J., Guillamat, R., Gutierrez, B., Campillo, M., Gento, P., et al. (2000). Increased morbid risk for schizophrenia in families of in-patients with bipolar illness. Schizophrenia Research, 42, 83–90.CrossRefGoogle ScholarPubMed
Wals, M., Hillegers, M. H. J., Reichart, C. G., Ormel, J., Nolen, W. A., & Verhulst, F. C. (2001). Prevalence of psychopathology in children of a bipolar parent. Journal of the American Academy of Child & Adolescent Psychiatry, 40, 664–671.Google ScholarPubMed
Weissman, M. M., Fendrich, M., Warner, V., & Wickramaratne, P. (1992). Incidence of psychiatric disorder in offspring at high and low risk for depression. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 640–648.CrossRefGoogle ScholarPubMed
Weissman, M. M., Prusoff, B. A., Gammon, G. D., Merikangas, K. R., Leckman, J. F., & Kidd, K. K. (1984). Psychopathology in the children (ages 6–18) of depressed and normal parents. Journal of the American Academy of Child & Adolescent Psychiatry, 23, 78–84.Google ScholarPubMed
Zahn-Waxler, C., Mayfield, A., Radke-Yarrow, M., McKnew, D. H., Cytryn, L., & Davenport, Y. B. (1988). A follow-up investigation of offspring of parents with bipolar disorder. American Journal of Psychiatry, 145, 506–509.Google ScholarPubMed