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Peeling the onion: NMDA dysfunction as a unifying model in schizophrenia

Published online by Cambridge University Press:  03 September 2003

Daniel C. Javitt
Daniel C. Javitt*
Affiliation:
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962 javitt@nki.rfmh.org http://www.rfmh.org/nki
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Abstract

N-methyl-d-aspartate receptor (NMDAR) dysfunction plays a crucial role in schizophrenia, leading to impairments in cognitive coordination. NMDAR agonists (e.g., glycine) ameliorate negative and cognitive symptoms, consistent with NMDAR models. However, not all types of cognitive coordination use NMDAR. Further, not all aspects of cognitive coordination are impaired in schizophrenia, suggesting the need for specificity in applying the cognitive coordination construct.

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Behavioral and Brain Sciences , Volume 26 , Issue 1 , February 2003 , pp. 93 - 94
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Copyright © Cambridge University Press 2003

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